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ClinicalTrials.gov 6 recruiting now official registry

Immune System Diseases clinical trials

Every US clinical trial registered for Immune System Diseases — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

19 US clinical trials · 6 currently recruiting

The research picture

Immune System Diseases has 19 registered US clinical trials, 6 of them open to new participants right now — about 32% of the total.

6
recruiting participants now
32%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
7
top sponsor: UNC Lineberger Comprehensive Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 800 participants

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001406

RECRUITING 600 participants

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00006150

RECRUITING Phase 2 354 participants

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

National Cancer Institute (NCI)

NCT02579967

RECRUITING Phase 2 330 participants

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

National Cancer Institute (NCI)

NCT03922724

RECRUITING Phase 2 66 participants

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

National Cancer Institute (NCI)

NCT04339777

RECRUITING Phase 2 39 participants

A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

Memorial Sloan Kettering Cancer Center

NCT05787574

ACTIVE NOT RECRUITING Phase 2 90 participants

A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy

Aravax Pty

NCT05621317

ACTIVE NOT RECRUITING Phase 2 71 participants

Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

National Cancer Institute (NCI)

NCT03663933

ACTIVE NOT RECRUITING Phase 1 43 participants

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

UNC Lineberger Comprehensive Cancer Center

NCT03602157

ACTIVE NOT RECRUITING Phase 1 38 participants

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

UNC Lineberger Comprehensive Cancer Center

NCT02690545

ACTIVE NOT RECRUITING 32 participants

Immuno-Oncology Database and Bioregistry

UNC Lineberger Comprehensive Cancer Center

NCT04656873

ACTIVE NOT RECRUITING Phase 1 25 participants

Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma

UNC Lineberger Comprehensive Cancer Center

NCT03672318

ACTIVE NOT RECRUITING Phase 1 19 participants

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT03696784

ACTIVE NOT RECRUITING Phase 1 18 participants

Administration of T Lymphocytes for Prevention of Relapse of Lymphomas

UNC Lineberger Comprehensive Cancer Center

NCT02663297

ACTIVE NOT RECRUITING Phase 1 17 participants

Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL

UNC Lineberger Comprehensive Cancer Center

NCT03016377

COMPLETED NA 95 participants

Asthma Data Innovation Demonstration Project

David Van Sickle

NCT02162576

COMPLETED 48 participants

Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab

Dragonfly Research

NCT04837651

COMPLETED Phase 4 33 participants

Mesalamine to Reduce T Cell Activation in HIV Infection

University of California, San Francis

NCT01090102

COMPLETED Phase 1 30 participants

A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers

HI-Bio, A Biogen Company

NCT05928585

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 6
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Immune System Diseases Trial Landscape

ClinicalTrials.gov lists 19 US studies indexed under Immune System Diseases, and 6 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Immune System Diseases shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Immune System Diseases is led by UNC Lineberger Comprehensive Cancer Center with 7 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Immune System Diseases?

PlainTrial tracks 19 US clinical trials for Immune System Diseases, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Immune System Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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