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Immune System Diseases clinical trials
Every US clinical trial registered for Immune System Diseases — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
19 US clinical trials · 6 currently recruiting
The research picture
Immune System Diseases has 19 registered US clinical trials, 6 of them open to new participants right now — about 32% of the total.
- 6
- recruiting participants now
- 32%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 7
- top sponsor: UNC Lineberger Comprehensive Cancer Center
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001406
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00006150
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
National Cancer Institute (NCI)
NCT02579967
Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma
National Cancer Institute (NCI)
NCT03922724
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity
National Cancer Institute (NCI)
NCT04339777
A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition
Memorial Sloan Kettering Cancer Center
NCT05787574
A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy
Aravax Pty
NCT05621317
Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
National Cancer Institute (NCI)
NCT03663933
Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL
UNC Lineberger Comprehensive Cancer Center
NCT03602157
Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL
UNC Lineberger Comprehensive Cancer Center
NCT02690545
Immuno-Oncology Database and Bioregistry
UNC Lineberger Comprehensive Cancer Center
NCT04656873
Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma
UNC Lineberger Comprehensive Cancer Center
NCT03672318
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
UNC Lineberger Comprehensive Cancer Center
NCT03696784
Administration of T Lymphocytes for Prevention of Relapse of Lymphomas
UNC Lineberger Comprehensive Cancer Center
NCT02663297
Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL
UNC Lineberger Comprehensive Cancer Center
NCT03016377
Asthma Data Innovation Demonstration Project
David Van Sickle
NCT02162576
Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab
Dragonfly Research
NCT04837651
Mesalamine to Reduce T Cell Activation in HIV Infection
University of California, San Francis
NCT01090102
A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers
HI-Bio, A Biogen Company
NCT05928585
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 6 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Immune System Diseases Trial Landscape
ClinicalTrials.gov lists 19 US studies indexed under Immune System Diseases, and 6 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Immune System Diseases shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Immune System Diseases is led by UNC Lineberger Comprehensive Cancer Center with 7 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Immune System Diseases?
PlainTrial tracks 19 US clinical trials for Immune System Diseases, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Immune System Diseases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.