National Institute of Allergy and Infectious Diseases (NIAID)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Allergy and Infectious Diseases (NIAID) sits in the top decile of US sponsors by registered trial count (#5 of 15,742 sponsors by registered trial count).

2,006 total trials 155 currently recruiting 1642 completed early-phase tilt top decile by trial count

National Institute of Allergy and Infectious Diseases (NIAID): 2,006 sponsored US clinical trials, 155 recruiting.

National Institute of Allergy and Infectious Diseases (NIAID) sponsors 2,006 registered US clinical trials on ClinicalTrials.gov, 155 of them currently recruiting, and 1,642 completed. 177 of these trials are in Phase 3-4 (later-stage) and 1,291 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is HIV Infections, with 195 trials.

Top-decile sponsor footprint

National Institute of Allergy and Infectious Diseases (NIAID) ranks in the top decile of sponsors by registered trial count (#5 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 68/100

1,642 of 1,802 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

2,006 total, page 22 of 41

COMPLETED Phase 1

A/H5N1 Vaccine in Healthy Children Aged 2-9 Years

NCT00133536

COMPLETED Phase 1

Safety of and Immune Response to the Experimental Preventive HIV Vaccine, EP HIV-1090, in Healthy, HIV-1 Uninfected Adults

NCT00141024

COMPLETED Phase 1

Safety, Tolerability and Immune Response to LC002, an Experimental Therapeutic Vaccine, in Adults Receiving HAART

NCT00270205

COMPLETED Phase 1

Safety and Immune Response to a Prime-Boost Vaccination Schedule in HIV-infected Patients

NCT00270465

TERMINATED

Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States

NCT00266513

COMPLETED Phase 1

STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency

NCT00263237

COMPLETED Phase 2

Pentavalent DTaP-Hep B-IPV

NCT00133445

COMPLETED

Immune Response to Varicella Vaccination in Children With Atopic Dermatitis

NCT00406081

COMPLETED Phase 1

Omalizumab to Treat Hyper-IgE (Job's) Syndrome

NCT00260702

COMPLETED

Immune Response to Mycobacterium Tuberculosis Infection

NCT00257907

COMPLETED Phase 2

The Immunological and Blood Effects of STA-5326 Mesylate on Patients With Crohn's Disease

NCT00250198

COMPLETED Phase 2

Immunogenicity and Safety of Different Doses of Fluzone® Influenza

NCT00253734

COMPLETED NA

Safety, Effectiveness, and Tolerability of Ezetimibe Combined With Statins for the Treatment of High Cholesterol in HIV Infected Adults

NCT00099684

COMPLETED

Chart Review of Antivirals for Influenza in Infants

NCT00311701

COMPLETED Phase 1

Open Label Evaluation of H5N1 Vaccine at Vaccine Manufacturing Facilities

NCT00311649

COMPLETED NA

T-cell Response-Flu Risk in Older Adults

NCT00138398

COMPLETED

RSV Disease in the Elderly

NCT00246480

COMPLETED NA

Cell-Mediated Immune Responses to Influenza A/H5N1 Vaccine

NCT00311727

COMPLETED Phase 2

H5 Booster After a Two Dose Schedule

NCT00240968

COMPLETED Phase 1

ACAM 3000 MVA at Harvard Medical School

NCT00133575

COMPLETED Phase 1

Revaccination With Subunit Influenza A/Vietnam/1203/2004 (H5N1) Vaccine

NCT00240903

COMPLETED NA

Differences in Blood Levels of Lopinavir/Ritonavir in HIV Infected Men and Women

NCT00102986

COMPLETED Phase 1

Monoclonal Antibody for Treatment of Inhalation Anthrax

NCT00138411

COMPLETED Phase 2

Gradual Withdrawal of Immune System Suppressing Drugs in Patients Receiving a Liver Transplant

NCT00135694

COMPLETED Phase 1

Inactivated Influenza A/H5N1 Vaccine in the Elderly

NCT00230750

TERMINATED Phase 1

Immune Responses to Two Dose Varivax +/- MMR-II

NCT00258726

COMPLETED Phase 2

Effect of Intermittent Aldesleukin Treatment With or Without Anti-HIV Drugs in HIV Infected People

NCT00110812

COMPLETED Phase 2

Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes

NCT00129259

COMPLETED Phase 1

A Phase I Safety and Immunogenicity Study of Mix and Match of Licensed Flu Vaccine and Flumist

NCT00231907

COMPLETED Phase 2

HVTN Protocol 204 - A Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, Followed by a Multiclade Recombinant Adenoviral Vector HIV-1 Vaccine Boost, VRCHIVADV014-00-VP, in HIV-1 Uninfected Adult Participants

NCT00125970

COMPLETED Phase 2

Comparison of Delivery Routes of Flu Vaccine in Adults

NCT00170547

COMPLETED

Analysis of Lyme Disease Lesions

NCT00132327

COMPLETED Phase 4

Comparison of Inactivated and Live, Attenuated Influenza Vaccine in Children 5-9 Years of Age-Year 3 Amendment

NCT00138385

TERMINATED

Herpevac Neonatal Substudy

NCT00138320

COMPLETED Phase 1

Safety of and Immune Response to a Tick-Borne Encephalitis Vaccine (LGT(TP21)/DEN4) in Healthy Adults

NCT00118924

COMPLETED Phase 1

H5N1 Vaccine Intramuscular Versus Intradermal in Healthy Adults

NCT00310206

COMPLETED

Controlling Acute or Early HIV Infection With Antiretroviral Drugs, Without a Candidate Vaccine.As Reported Previously, the Candidate Vaccie Was Not Provided by the Maufacturer as Promised

NCT00238459

COMPLETED

Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis

NCT00407979

COMPLETED Phase 1

Safety of and Immune Response to a Bird Flu Virus Vaccine (H9N2) in Healthy Adults (Study A)

NCT00110279

COMPLETED

Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus

NCT00407069

COMPLETED Phase 2

Immune System Suppression With Alemtuzumab and Tacrolimus in Liver Transplantation Patients

NCT00105235

COMPLETED

SCOT Scleroderma Treatment Alternative Registry (STAR Registry)

NCT00860548

COMPLETED NA

Young Adult Influenza Vaccine Immunogenicity Substudy

NCT00170508

COMPLETED Phase 2

Scleroderma: Cyclophosphamide or Transplantation

NCT00114530

COMPLETED Phase 1

Adjuvant Cytokine Therapy to Treat Pulmonary Mycobacterium Avium Complex Infection

NCT00111397

COMPLETED Phase 2

Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis

NCT00145249

COMPLETED NA

Effect of Tenofovir Disoproxil Fumarate on Lipid Levels in HIV Infected Adults on Stable Anti-HIV Drug Therapy

NCT00109603

COMPLETED Phase 2

Atorvastatin (Lipitor) Therapy in Patients With Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis

NCT00094172

COMPLETED Phase 1

AMA1-C1/Alhydrogel + CpG 7909 for Malaria

NCT00344539

COMPLETED Phase 1

"Prime-Boost" Vaccine Schedule for Prevention of HIV Infection

NCT00109629

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Phase Distribution

PhaseTrial count
Phase 1 858
Phase 2 433
Phase 3 123
Phase 4 54

What is open in the National Institute of Allergy and Infectious Diseases (NIAID) pipeline

155 recruiting of 2,006 indexed (8% open); 1,642 completed (82%).

Phase mix: 177 late (III/IV) vs 1,291 early (I/II) (early-phase heavy).

Top condition: HIV Infections (195 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Allergy and Infectious Diseases (NIAID): open-pipeline peers nationwide

Peers matched on 2,006 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,0002,500 5%10%15%20% Total trials Recruiting share National Institute of Allergy and Infectious Diseases (NIAID)Massachusetts General HospitalMemorial Sloan Kettering Cancer CenterPfizerStanford UniversityAlumisAndrei IagaruBioXcel TherapeuticsCorporal Michael J. Crescenz VA Medical Center
National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 2,006 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Allergy and Infectious Diseases (NIAID) page

2,006 registered trials is a research-attention snapshot, not an endorsement of National Institute of Allergy and Infectious Diseases (NIAID) or any single study.

  • 155 of National Institute of Allergy and Infectious Diseases (NIAID)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • HIV Infections is the condition National Institute of Allergy and Infectious Diseases (NIAID) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See HIV Infections trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Allergy and Infectious Diseases (NIAID) pipeline card: 2,006 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.