Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07656259 · ClinicalTrials.gov registry record · NA
COMPARE-VENT Feasibility Pilot Study
A NA study, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- NA
- Development phase
- 75
- Enrollment target
NCT07656259: Recruiting NA study, sponsored by Mayo Clinic.
NCT07656259 is a NA study that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 75 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07656259, a NA study, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- NA
- Development phase
- 75 participants
- Enrollment target
Study Summary
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among patients with impaired cardiovascular reserve is further compounded by the adverse impact of positive pressure ventilation (PPV) and systemic sedation on intracardiac hemodynamics, pulmonary vascular mechanics and consequently end-organ perfusion. Despite widespread use, evidence guiding optimal ventilatory practices and mode selection in cardiovascular intensive care unit patients remains limited. Pressure-controlled and volume-controlled ventilation may differ in their effects on patient-ventilator synchrony, sedation requirements, and hemodynamic impact, but comparative data among patients with critical cardiac disease remains inconclusive. This pilot study will evaluate the feasibility of implementing a pragmatic cluster-randomized crossover trial comparing ventilatory modes in a contemporary cardiovascular intensive care unit.
Interventions
- OTHER Volume Controlled Mode
- OTHER Pressure Controlled Mode
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2026-07-01 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07656259
The ClinicalTrials.gov registry entry for NCT07656259 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 75 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Volume Controlled Mode is the first listed.
NCT07656259 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07656259 about?
NCT07656259 is a clinical study titled "COMPARE-VENT Feasibility Pilot Study". Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among pat...
What is the current status of trial NCT07656259?
This trial is currently recruiting. It is a NA study. The enrollment target is 75 participants. The study started on 2026-07-01. Estimated completion is 2027-06-30.
What interventions are being tested in trial NCT07656259?
The interventions under investigation include: Volume Controlled Mode (OTHER), Pressure Controlled Mode (OTHER).
Who is sponsoring clinical trial NCT07656259?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.