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NCT07656259 · ClinicalTrials.gov registry record · NA
COMPARE-VENT Feasibility Pilot Study
A NA study, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- NA
- Development phase
- 75
- Enrollment target
NCT07656259: Recruiting NA study, sponsored by Mayo Clinic.
NCT07656259 is a NA study that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 75 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07656259, a NA study, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- NA
- Development phase
- 75 participants
- Enrollment target
Study Summary
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among patients with impaired cardiovascular reserve is further compounded by the adverse impact of positive pressure ventilation (PPV) and systemic sedation on intracardiac hemodynamics, pulmonary vascular mechanics and consequently end-organ perfusion. Despite widespread use, evidence guiding optimal ventilatory practices and mode selection in cardiovascular intensive care unit patients remains limited. Pressure-controlled and volume-controlled ventilation may differ in their effects on patient-ventilator synchrony, sedation requirements, and hemodynamic impact, but comparative data among patients with critical cardiac disease remains inconclusive. This pilot study will evaluate the feasibility of implementing a pragmatic cluster-randomized crossover trial comparing ventilatory modes in a contemporary cardiovascular intensive care unit.
Primary Outcome
Percentage of time spent on the assigned study mode while receiving invasive mechanical ventilation in the cardiac ICU between enrollment and 48 hours after enrollment.
Interventions
- OTHER Volume Controlled Mode
- OTHER Pressure Controlled Mode
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2026-07-01 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT07656259 shows while recruiting
NCT07656259 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Volume Controlled Mode is the first listed.
NCT07656259 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07656259 about?
NCT07656259 is a clinical study titled "COMPARE-VENT Feasibility Pilot Study". Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among pat...
What is the current status of trial NCT07656259?
This trial is currently recruiting. It is a NA study. The enrollment target is 75 participants. The study started on 2026-07-01. Estimated completion is 2027-06-30.
What interventions are being tested in trial NCT07656259?
The interventions under investigation include: Volume Controlled Mode (OTHER), Pressure Controlled Mode (OTHER).
Who is sponsoring clinical trial NCT07656259?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07656259's enrollment target sits among peer trials
75 1069th of 2000 higher than 919 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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