Children's Hospital of Philadelphia

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Children's Hospital of Philadelphia sits in the top decile of US sponsors by registered trial count (#81 of 15,742 sponsors by registered trial count).

431 total trials 78 currently recruiting 300 completed early-phase tilt top decile by trial count

Children's Hospital of Philadelphia: 431 sponsored US clinical trials, 78 recruiting.

Children's Hospital of Philadelphia sponsors 431 registered US clinical trials on ClinicalTrials.gov, 78 of them currently recruiting, and 300 completed. 35 of these trials are in Phase 3-4 (later-stage) and 81 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Pediatric Cancer, with 5 trials.

Top-decile sponsor footprint

Children's Hospital of Philadelphia ranks in the top decile of sponsors by registered trial count (#81 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 65/100

300 of 333 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (90.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

431 total, page 8 of 9

COMPLETED Phase 2

Vitamin D Dose Finding Study

NCT01092338

COMPLETED

Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery?

NCT00994656

COMPLETED NA

Comprehensive Clinical Decision Support (CDS) for the Primary Care of Premature Infants

NCT01478711

COMPLETED NA

Family Functioning and Child Behavior When a Sibling is Critically Ill

NCT00912626

COMPLETED Phase 2

Evaluating a Website for Parents of Injured Children

NCT00974467

COMPLETED Phase 3

MOM Program 8-Year Follow-up

NCT00970853

COMPLETED Phase 2

Phase II Safety and Efficacy Study of 18FDOPA PET-CT in Children With Hyperinsulinemic Hypoglycemia

NCT01468454

COMPLETED

Pharmacogenomics Analysis of Morphine Pharmacokinetics in Pediatric Tonsillectomy and Adenoidectomy

NCT00836264

COMPLETED

Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction

NCT02135081

COMPLETED Phase 2

Translating Evidence Based Developmental Screening Into Pediatric Primary Care

NCT00844246

COMPLETED

Feasibility Study for PANDAS

NCT00754897

COMPLETED NA

Improving Informed Consent in Pediatric Endoscopy

NCT00899392

TERMINATED Phase 2

Application of Impedance Threshold Device Technologies to Treat and Prevent Hypotension During Dialysis

NCT00576524

COMPLETED

Remifentanil Propofol Infusion in Pediatric Spinal Surgery

NCT00761072

COMPLETED

Emergency Bedside Ultrasound for Pediatric Soft Tissue Infections

NCT00595881

COMPLETED Phase 2

Family Therapy as Hospital Aftercare for Adolescent Suicide Attempters

NCT01195740

TERMINATED Phase 1

Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas

NCT00716469

TERMINATED

Pharmacokinetics and Pharmacdynamics of Sildenafil

NCT00718185

COMPLETED

Arterial Spin Labeling Perfusion Magnetic Resonance (MR) Imaging in Pediatric Brain Tumors

NCT00907244

COMPLETED

Spine Quantitative Computed Tomography (QCT)

NCT00762879

COMPLETED

Craniofacial Surgery Perioperative Registry

NCT00658242

COMPLETED Phase 1

Preventing Depression in the Children of Depressed African American Mothers

NCT00904917

COMPLETED Phase 3

Improving Otitis Media Care With Clinical Decision Support

NCT00581711

COMPLETED NA

A Pilot Study to Measure Blood Levels of Desflurane in Children

NCT00577369

COMPLETED Phase 3

Effectiveness of Treatment for Relational Aggression in Urban African American Girls

NCT00510094

COMPLETED

Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials

NCT00596609

COMPLETED Phase 2

Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)

NCT00529191

COMPLETED NA

"Just-In-Time Training" in Pediatric Airway Management

NCT00631176

COMPLETED NA

CPR Rescuer Fatigue on Chest Compression Effectiveness

NCT01117896

COMPLETED NA

Evaluation of Adherence and Therapeutic Effectiveness of Bi-Flex Versus CPAP in Children With OSA

NCT00458406

COMPLETED Phase 3

Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury

NCT00451282

COMPLETED

Q-CPR Compression Sensor Size Qualification in Children

NCT00630773

COMPLETED NA

Bone Health in Pediatric Crohn's Disease: A Low Magnitude Mechanical Stimulus Trial

NCT00364130

COMPLETED

Feasibility of Ventilation Detection Via Standard Defibrillator Pads in Mechanically Ventilated Pediatric Patients

NCT00628875

COMPLETED

Effects of Sternal Wall Pressure in Children

NCT00628407

COMPLETED NA

Bone Health of Obese Adolescents During Weight Loss

NCT00609713

COMPLETED Phase 1

Sirolimus for Autoimmune Disease of Blood Cells

NCT00392951

COMPLETED Phase 4

Budesonide Inhalation Suspension for Acute Asthma in Children

NCT00393367

COMPLETED NA

Analgesic Efficacy After Umbilical Hernia Repair in Children

NCT00578136

COMPLETED Phase 4

Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea

NCT00572975

COMPLETED Phase 2

Treatment of Acute Migraine Headache in Children

NCT00355394

COMPLETED NA

Behavior Change Family Counseling to Reduce Rate of Weight Gain in At-Risk Children

NCT00241891

COMPLETED

Quantitative Measurement of Cardiopulmonary Resuscitation (CPR) During In Hospital Cardiac Arrest

NCT00628693

TERMINATED

Pharmacokinetics and Pharmacodynamics of Pentobarbital in Neonates, Infants, and Children Following Open Heart Surgery

NCT00577434

COMPLETED NA

Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma

NCT00294398

COMPLETED Phase 4

Oral Prednisolone Dosing in Children Hospitalized With Asthma

NCT00257933

COMPLETED NA

Effect of Simulation on PALS Training

NCT00562744

COMPLETED NA

Electronic Health Record (EHR) Decision Support to Improve Outpatient Asthma Care

NCT00918944

COMPLETED

Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population

NCT00715949

COMPLETED

Fluconazole Pharmacokinetics in Infants

NCT00514358

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What is open in the Children's Hospital of Philadelphia pipeline

78 recruiting of 431 indexed (18% open); 300 completed (70%).

Phase mix: 35 late (III/IV) vs 81 early (I/II) (early-phase heavy).

Top condition: Pediatric Cancer (5 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Children's Hospital of Philadelphia: open-pipeline peers nationwide

Peers matched on 431 registered trials and 18% open enrollment, not the therapeutic-area sidebar.

Children's Hospital of Philadelphia sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600800 0%10%20%30% Total trials Recruiting share Children's Hospital of PhiladelphiaNovo Nordisk A/SUniversity of Illinois at ChicagoVanderbilt UniversityDartmouth-Hitchcock Medical CenterWeill Medical College of Cornell UniversityUniversity of California, BerkeleyGeorge Washington UniversityHospital for Special Surgery, New York
Children's Hospital of Philadelphia sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Children's Hospital of Philadelphia sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 431 trials (± recruiting share)

Sponsors near 18% open enrollment (± trial volume)

What to do with this Children's Hospital of Philadelphia page

431 registered trials is a research-attention snapshot, not an endorsement of Children's Hospital of Philadelphia or any single study.

  • 78 of Children's Hospital of Philadelphia's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Pediatric Cancer is the condition Children's Hospital of Philadelphia studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Pediatric Cancer trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Children's Hospital of Philadelphia pipeline card: 431 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.