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ClinicalTrials.gov 2 recruiting now official registry

Wet Age-related Macular Degeneration clinical trials

2 of 9 indexed Wet Age-related Macular Degeneration trials are currently recruiting.

9 US clinical trials · 2 currently recruiting

Wet Age-related Macular Degeneration is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Kodiak Sciences, running 2 of these trials.

The research picture

Wet Age-related Macular Degeneration has 9 registered US clinical trials, 2 of them open to new participants right now, about 22% of the total.

2
recruiting participants now
22%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
2
top sponsor: Kodiak Sciences
Phase 11Phase 22Phase 35

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 3 660 participants

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

AbbVie

NCT05407636

RECRUITING Phase 2 630 participants

Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD

AbbVie

NCT04704921

ACTIVE NOT RECRUITING Phase 3 675 participants

A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK

Kodiak Sciences

NCT06556368

ACTIVE NOT RECRUITING Phase 3 400 participants

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56

EyePoint Pharmaceuticals

NCT06668064

ACTIVE NOT RECRUITING Phase 3 400 participants

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56

EyePoint Pharmaceuticals

NCT06683742

ACTIVE NOT RECRUITING Phase 1 30 participants

NT-101 Topical Ophthalmic Solution in Patients With Wet AMD

NexThera Co.

NCT06704009

ACTIVE NOT RECRUITING 23 participants

Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]

Adverum Biotechnologies

NCT04645212

COMPLETED Phase 3 557 participants

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

Kodiak Sciences

NCT04964089

COMPLETED Phase 2 20 participants

A Study to Evaluate the Neovista Ophthalmic System for the Treatment of Subfoveal CNV in Patients With AMD That Have Failed Primary Anti-VEGF Therapy

NeoVista

NCT00679445

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 5

Top Sponsors

Kodiak Sciences 2 trials
AbbVie 2 trials
NeoVista 1 trials
NexThera Co. 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Wet Age-related Macular Degeneration Trial Landscape

9 indexed Wet Age-related Macular Degeneration studies · 2 recruiting (22%).

Phase mix: 5 late (III/IV) vs 3 early (I/II).

Top sponsor: Kodiak Sciences (2 trials), 5 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Wet Age-related Macular Degeneration?

PlainTrial tracks 9 US clinical trials for Wet Age-related Macular Degeneration, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Wet Age-related Macular Degeneration?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.