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NCT06683742 · ClinicalTrials.gov registry record · Phase 3
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
A Phase 3 study of Wet Age-related Macular Degeneration and wAMD, sponsored by EyePoint Pharmaceuticals.
- Active
- Registry status
- Phase 3
- Development phase
- 400
- Enrollment target
- 20
- Study locations
NCT06683742: Active Phase 3 study of Wet Age-related Macular Degeneration and wAMD, sponsored by EyePoint Pharmaceuticals.
NCT06683742 is a Phase 3 study of Wet Age-related Macular Degeneration and wAMD that is active but no longer recruiting, run by EyePoint Pharmaceuticals. The registered enrollment target is 400 participants, roughly in line with the 374-participant average among 8 other Wet Age-related Macular Degeneration trials with a reported enrollment target. The trial reports 20 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06683742, a Phase 3 study of Wet Age-related Macular Degeneration and wAMD, is active but no longer recruiting, sponsored by EyePoint Pharmaceuticals.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 400 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Conditions Studied
Interventions
- DRUG EYP-1901
- DRUG Aflibercept (2.0 mg)
Study Locations (20)
California
- Win Retina - Arcadia
- Doctor Retina, PC - Beverly Hills
- The Retina Partners - Encino
- RCOC Clinical Research Institute Inc. - Fullerton
- Global Research Management, Inc. - Glendale
- Atlantis Eyecare - Huntington Beach
- South Coast Retina Center - Long Beach
- Retinal Consultants Medical Group - Modesto
- Northern California Retina Vitreous Associates Medical Group INC. - Mountain View
- Kaiser Permanente - Oakland
- California Retina Consultants Oxnard Office - Oxnard
- Retina Consultants San Diego - Poway
- California Eye Specialists Medical Group, Inc. - Redlands
- Retina Consultants of Southern California - Redlands
- SCPMG/Kaiser Permanente Riverside Medical Center - Riverside
- VRMG Inc - Sacramento
Arizona
- Associated Retina Consultans - Gilbert
- Associated Retina Consultants - Phoenix - Phoenix
- Phoenix Retina Clinical Trials, LLC - Phoenix
- Retina Macula Institute of Arizona - Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2024-11-27 |
| Est. Completion | 2027-10 |
| Phase | Phase 3 |
What the registry record for NCT06683742 still lists
NCT06683742 is an interventional study that assigns participants to a tested intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 374-participant average among 8 other Wet Age-related Macular Degeneration trials with a reported enrollment target.
The record links to 2 conditions, with Wet Age-related Macular Degeneration appearing as the primary indexed condition, and to 2 interventions - of which EYP-1901 is the first listed.
NCT06683742 names 20 study sites across 2 states, led by California, Arizona.
Frequently Asked Questions
What is clinical trial NCT06683742 about?
NCT06683742 is a clinical study titled "A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56". This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
What is the current status of trial NCT06683742?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 400 participants. The study started on 2024-11-27. Estimated completion is 2027-10.
What conditions does trial NCT06683742 study?
This clinical trial studies the following conditions: Wet Age-related Macular Degeneration, wAMD.
What interventions are being tested in trial NCT06683742?
The interventions under investigation include: EYP-1901 (DRUG), Aflibercept (2.0 mg) (DRUG).
Who is sponsoring clinical trial NCT06683742?
This trial is sponsored by EyePoint Pharmaceuticals, which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06683742 being conducted?
This trial has 20 study locations across Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Wet Age-related Macular Degeneration
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06683742's enrollment target sits among peer trials
400 5th of 8 higher than 3 of 8 other Wet Age-related Macular Degeneration trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Wet Age-related Macular Degeneration trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
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-
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK
ACTIVE NOT RECRUITING · Phase 3
-
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56
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-
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
COMPLETED · Phase 3
-
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RECRUITING · Phase 2
-
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
ACTIVE NOT RECRUITING
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