Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance-Related Disorders: full-pipeline trial registry
19 of 64 indexed Substance-Related Disorders trials are currently recruiting.
Corpus placement: #215 of 28,707 conditions by registered trial count.
64 US clinical trials · 19 currently recruiting · #215 of 28,707 conditions by registered trial count
Substance-Related Disorders: 64 US clinical trials tracked, 19 recruiting.
Substance-Related Disorders is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute on Drug Abuse (NIDA), running 10 of these trials.
Enrollment posture brief
Registry condition substance-related-disorders
OPEN 19 | RECR 30% | LATE 14 | EARLY 15 | RANK #215 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Chronic Obstructive Pulmonary Disease (COPD) (30% recruiting · 37 trials)
Substance-Related Disorders lists 19 open slots (30% of 64 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance-Related Disorders on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance-Related Disorders is recruiting below its size-band peers.
19 of 64 indexed trials (29.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Substance-Related Disorders research.
National Institute on Drug Abuse (NIDA) accounts for 10 of 64 trials (15.6%). 37 distinct sponsors appear on at least one study for this condition label.
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Typical Substance-Related Disorders enrolment sits around 134 participants.
Median target enrolment is 134 among the 59 trials that report a genuine target (sentinel values excluded). 25 of those (42.4%) plan for fewer than 100 participants.
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Substance-Related Disorders research is mostly interventional.
62 interventional and 2 observational studies make up this index (96.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
64 total, page 2 of 2
Quetiapine for Cocaine Use and Cravings
Seattle Institute for Biomedical and Clinical Research
NCT00232336
Brief Intervention for Substance Use and Partner Abuse Among Females in the ER
Rhode Island Hospital
NCT01709552
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
New River Pharmaceuticals
NCT00248092
Pilot Clinical Trial of Computer-based Motivational Intervention - 1
Wayne State University
NCT00230022
Exercise and Treatment-as-usual in Substance Use Treatment Outcomes
University of Wisconsin, Madison
NCT02570360
Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
Stanford University
NCT01006707
Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2
University of Chicago
NCT00000250
Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8
University of Chicago
NCT00000256
A Laboratory Model for Heroin Abuse Medications - 8
New York State Psychiatric Institute
NCT00000273
Modeling Impaired Judgement in Cocaine Abusers - 6
National Institute on Drug Abuse (NIDA)
NCT00015236
Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11
National Institute on Drug Abuse (NIDA)
NCT00015301
Buprenorphine Maintenance for Opiate Dependence - 6
National Institute on Drug Abuse (NIDA)
NCT00000357
Prepulse Inhibition of Startle in Cocaine Dependence - 7
National Institute on Drug Abuse (NIDA)
NCT00015249
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 7
National Institute on Drug Abuse (NIDA)
NCT00000358
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 3 | 7 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance-Related Disorders records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance-Related Disorders trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance-Related Disorders page
64 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Substance-Related Disorders trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute on Drug Abuse (NIDA) sponsors the most Substance-Related Disorders trials on record, review their full trial history before evaluating a specific study. See National Institute on Drug Abuse (NIDA)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance-Related Disorders condition card totals 64 registered trials; most-linked intervention Behavior Therapy; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.