Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Stage IV Prostate Cancer

Open-data reference.

22 US clinical trials ·

Active & Recent Trials

ACTIVE NOT RECRUITING Phase 4 100 participants

Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer

Northwestern University

NCT03016741

ACTIVE NOT RECRUITING Phase 2 70 participants

Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

Northwestern University

NCT03012321

ACTIVE NOT RECRUITING Phase 2 37 participants

Abiraterone Acetate, Niclosamide, and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer

Mamta Parikh

NCT02807805

ACTIVE NOT RECRUITING Phase 2 32 participants

First Strike, Second Strike Therapies for High Risk Metastatic Castration Sensitive Prostate Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT05189457

ACTIVE NOT RECRUITING Phase 2 30 participants

Enzalutamide With or Without Radium Ra 223 Dichloride in Patients With Metastatic, Castration-Resistant Prostate Cancer

University of Southern California

NCT03344211

ACTIVE NOT RECRUITING Phase 1 25 participants

Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer

Thomas Jefferson University

NCT02023463

ACTIVE NOT RECRUITING Early Phase 1 17 participants

Intermittent Androgen Deprivation Therapy for Stage IV Castration Sensitive Prostate Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT03511196

ACTIVE NOT RECRUITING Phase 2 14 participants

Trametinib in Treating Patients With Progressive Metastatic Hormone-Resistant Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT02881242

COMPLETED Phase 3 1,050 participants

Docetaxel and Prednisone With or Without Bevacizumab in Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

National Cancer Institute (NCI)

NCT00110214

COMPLETED Phase 2 112 participants

Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer

Mayo Clinic

NCT00170157

COMPLETED Phase 1 100 participants

Treating Patients With Metastatic Prostate Cancer Not Responding to Hormone and Chemotherapy

National Cancer Institute (NCI)

NCT00331344

COMPLETED Phase 1 88 participants

Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer

University of Chicago

NCT02012296

COMPLETED Phase 1 80 participants

Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors

National Cancer Institute (NCI)

NCT00058253

COMPLETED Phase 2 78 participants

Tivantinib in Treating Patients With Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT01519414

COMPLETED Phase 2 54 participants

CYT107 After Vaccine Treatment (Provenge®) in Patients With Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT01881867

COMPLETED NA 32 participants

Soy Isoflavones in Treating Patients With Recurrent Prostate Cancer or Rising Prostate-Specific Antigen

Ohio State University Comprehensive Cancer Center

NCT01682941

COMPLETED Phase 2 19 participants

Magnetic Resonance Imaging in Measuring the Effect of Cabozantinib in Patients With Castrate Resistant Prostate Cancer

University of Chicago

NCT01599793

COMPLETED Phase 2 17 participants

17-AAG in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Previous Hormone Therapy

National Cancer Institute (NCI)

NCT00118092

COMPLETED Phase 2 17 participants

Linsitinib in Treating Patients With Asymptomatic or Mildly Symptomatic Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT01533246

COMPLETED Phase 1 15 participants

Sodium Selenite and Radiation Therapy in Treating Patients With Metastatic Cancer

Stanford University

NCT02184533

COMPLETED Phase 2 14 participants

Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway

University of Washington

NCT02598895

COMPLETED Phase 2 2 participants

Sipuleucel-T With or Without Tasquinimod in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

Roswell Park Cancer Institute

NCT02159950

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 13
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IV Prostate Cancer Trial Landscape

ClinicalTrials.gov lists 22 US studies indexed under Stage IV Prostate Cancer, and 0 of those are currently open to recruitment — roughly 0% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Stage IV Prostate Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 19 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Stage IV Prostate Cancer is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IV Prostate Cancer?

PlainTrial tracks 22 US clinical trials for Stage IV Prostate Cancer, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IV Prostate Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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