Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Small Lymphocytic Lymphoma (SLL)

Open-data reference.

15 US clinical trials · 8 currently recruiting

Active & Recent Trials

RECRUITING Phase 1 572 participants

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

Nurix Therapeutics

NCT05131022

RECRUITING 300 participants

A Study of Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT06788639

RECRUITING Phase 1 248 participants

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Nurix Therapeutics

NCT04830137

RECRUITING Phase 2 100 participants

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

Nurix Therapeutics

NCT07221500

RECRUITING 100 participants

Predictors of Health-Related QOL in Adults With CLL or Small Lymphocytic Lymphoma

H. Lee Moffitt Cancer Center and Research Institute

NCT07030400

RECRUITING Phase 2 45 participants

Zanubrutinib and Venetoclax in CLL (ZANU-VEN)

Dana-Farber Cancer Institute

NCT05168930

RECRUITING Phase 2 40 participants

Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL

Massachusetts General Hospital

NCT06849713

RECRUITING Early Phase 1 30 participants

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

National Heart, Lung, and Blood Institute (NHLBI)

NCT07428707

ACTIVE NOT RECRUITING Phase 1 666 participants

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

Genmab

NCT03625037

ACTIVE NOT RECRUITING Phase 2 81 participants

Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax

Memorial Sloan Kettering Cancer Center

NCT04419519

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

COMPLETED Phase 1 39 participants

Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

TG Therapeutics

NCT01647971

COMPLETED Phase 2 39 participants

Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma

University of Rochester

NCT03788291

COMPLETED Phase 1 24 participants

Study of AMD3100 (Plerixafor) and Rituximab in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Genzyme, a Sanofi Company

NCT00694590

COMPLETED Phase 1 18 participants

CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies

Calibr, a division of Scripps Research

NCT04450069

Phase Distribution

PhaseTrial count
Early Phase 1 8
Phase 2 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small Lymphocytic Lymphoma (SLL) Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under Small Lymphocytic Lymphoma (SLL), and 8 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Small Lymphocytic Lymphoma (SLL) shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Small Lymphocytic Lymphoma (SLL) is led by Nurix Therapeutics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small Lymphocytic Lymphoma (SLL)?

PlainTrial tracks 15 US clinical trials for Small Lymphocytic Lymphoma (SLL), of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small Lymphocytic Lymphoma (SLL)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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