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ClinicalTrials.gov 12 recruiting now official registry

Refractory Non-Hodgkin Lymphoma clinical trials

12 of 18 indexed Refractory Non-Hodgkin Lymphoma trials are currently recruiting.

18 US clinical trials · 12 currently recruiting

Refractory Non-Hodgkin Lymphoma is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Lyell Immunopharma, running 2 of these trials.

The research picture

Refractory Non-Hodgkin Lymphoma has 18 registered US clinical trials, 12 of them open to new participants right now, about 67% of the total.

12
recruiting participants now
67%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Lyell Immunopharma
Phase 112Phase 25Phase 31

Active & Recent Trials

18 total, page 1 of 1

RECRUITING Phase 3 400 participants

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Lyell Immunopharma

NCT07188558

RECRUITING Phase 1 270 participants

Study of LYL314 in Aggressive Large B-Cell Lymphoma

Lyell Immunopharma

NCT05826535

RECRUITING Phase 1 128 participants

IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers

Indapta Therapeutics

NCT06119685

RECRUITING Phase 1 80 participants

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

FBD Biologics Limited

NCT05892718

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 1 24 participants

Study of SIRPant-M in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma

SIRPant Immunotherapeutics

NCT05967416

RECRUITING Phase 2 24 participants

A Phase II Study of the Combination of Pembrolizumab and ATRA Combination Treatment of Relapsed HL and B-NHL

Rita Assi

NCT06484920

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 2 22 participants

CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL).

Lazaros Lekakis

NCT05260957

RECRUITING Phase 1 21 participants

T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)

Estrella Biopharma

NCT06343311

RECRUITING Phase 1 18 participants

SynKIR-310 for Relapsed/Refractory B-NHL

Verismo Therapeutics

NCT06544265

ACTIVE NOT RECRUITING Phase 2 350 participants

9-ING-41 in Patients with Advanced Cancers

Actuate Therapeutics

NCT03678883

ACTIVE NOT RECRUITING Phase 1 112 participants

A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

BeOne Medicines

NCT05828589

ACTIVE NOT RECRUITING Phase 1 33 participants

Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma

University of Nebraska

NCT05621096

ACTIVE NOT RECRUITING Phase 2 28 participants

Brentuximab Vedotin With or Without Nivolumab in Treating Patients With Relapsed or Refractory CD30+ Lymphoma

University of Washington

NCT01703949

ACTIVE NOT RECRUITING Phase 1 23 participants

Loncastuximab Tesirine and Venetoclax for Relapsed/ Refractory Non-Hodgkin Lymphoma

Paolo Caimi, MD

NCT05053659

ACTIVE NOT RECRUITING Phase 1 22 participants

Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT04640779

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 5
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Non-Hodgkin Lymphoma Trial Landscape

18 indexed Refractory Non-Hodgkin Lymphoma studies · 12 recruiting (67%).

Phase mix: 1 late (III/IV) vs 17 early (I/II).

Top sponsor: Lyell Immunopharma (2 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Non-Hodgkin Lymphoma?

PlainTrial tracks 18 US clinical trials for Refractory Non-Hodgkin Lymphoma, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Non-Hodgkin Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.