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NCT07188558 · ClinicalTrials.gov registry record · Phase 3
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
A Phase 3 study of Non-Hodgkin Lymphoma and Lymphoma, B-Cell, sponsored by Lyell Immunopharma.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 400
- Enrollment target
- 20
- Study locations
NCT07188558: Recruiting Phase 3 study of Non-Hodgkin Lymphoma and Lymphoma, B-Cell, sponsored by Lyell Immunopharma.
NCT07188558 is a Phase 3 study of Non-Hodgkin Lymphoma and Lymphoma, B-Cell that is actively recruiting participants, run by Lyell Immunopharma. The registered enrollment target is 400 participants, above the 164-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (144% higher). The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07188558, a Phase 3 study of Non-Hodgkin Lymphoma and Lymphoma, B-Cell, is actively recruiting participants, sponsored by Lyell Immunopharma.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 400 participants
- Enrollment target
- 20
- Study locations
Study Summary
This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma in the second-line setting.
Primary Outcome
The time interval from treatment initiation until the occurrence of a specific event of interest.
Conditions Studied
Interventions
- BIOLOGICAL rondecabtagene autoleucel
- BIOLOGICAL axicabtagene ciloleucel
- BIOLOGICAL lisocabtagene maraleucel
Study Locations (20)
Arizona
- Banner MD Anderson Cancer Center - Gilbert
- Honor Health - Scottsdale
- Mayo Clinic Arizona - Scottsdale
California
- Cedars-Sinai Medical Center - Los Angeles
- University of California, Los Angeles (UCLA) - Los Angeles
- University of California, Irvine - Orange
Florida
- Mayo Clinic Florida - Jacksonville
- AdventHealth - Orlando
- Moffitt Cancer Center - Tampa
Colorado
- University of Colorado - Aurora
- Colorado Blood Cancer Institute - Denver
Illinois
- Northwestern - Chicago
- University of Chicago - Chicago
Kentucky
- University of Kentucky - Lexington
- University of Louisville Health - Louisville
Arkansas
- University of Arkansas - Little Rock
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2026-01-12 |
| Est. Completion | 2032-01 |
| Phase | Phase 3 |
What NCT07188558 shows while recruiting
NCT07188558 is an interventional study that assigns participants to a tested intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, above the 164-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (144% higher).
The record links to 9 conditions, with Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which rondecabtagene autoleucel is the first listed.
NCT07188558 names 20 study sites across 11 states, led by Arizona, California, Florida.
Frequently Asked Questions
What is clinical trial NCT07188558 about?
NCT07188558 is a clinical study titled "A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy". This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma in the second-line setting.
What is the current status of trial NCT07188558?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 400 participants. The study started on 2026-01-12. Estimated completion is 2032-01.
What conditions does trial NCT07188558 study?
This clinical trial studies the following conditions: Non-Hodgkin Lymphoma, Lymphoma, B-Cell, Large B-cell Lymphoma, Refractory Non-Hodgkin Lymphoma, Relapsed Non-Hodgkin Lymphoma.
What interventions are being tested in trial NCT07188558?
The interventions under investigation include: rondecabtagene autoleucel (BIOLOGICAL), axicabtagene ciloleucel (BIOLOGICAL), lisocabtagene maraleucel (BIOLOGICAL).
Who is sponsoring clinical trial NCT07188558?
This trial is sponsored by Lyell Immunopharma, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07188558 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07188558's enrollment target sits among peer trials
400 10th of 106 higher than 97 of 106 other Non-Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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