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NCT05826535 · ClinicalTrials.gov registry record · Phase 1
Study of LYL314 in Aggressive Large B-Cell Lymphoma
A Phase 1 study of Non-Hodgkin Lymphoma and Large B-cell Lymphoma, sponsored by Lyell Immunopharma.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 270
- Enrollment target
- 20
- Study locations
NCT05826535: Recruiting Phase 1 study of Non-Hodgkin Lymphoma and Large B-cell Lymphoma, sponsored by Lyell Immunopharma.
NCT05826535 is a Phase 1 study of Non-Hodgkin Lymphoma and Large B-cell Lymphoma that is actively recruiting participants, run by Lyell Immunopharma. The registered enrollment target is 270 participants, above the 165-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (64% higher). The trial reports 20 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05826535, a Phase 1 study of Non-Hodgkin Lymphoma and Large B-cell Lymphoma, is actively recruiting participants, sponsored by Lyell Immunopharma.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 270 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive large B-cell lymphoma.
Primary Outcome
Incidence of dose-limiting toxicities (DLTs) and other treatment-emergent adverse events (TEAEs)
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG LYL314
Study Locations (20)
California
- University of California-Irvine Medical Center - Irvine
- Cedars-Sinai Medical Center - Los Angeles
- University of California, Los Angeles (UCLA) Medical Center - Los Angeles
- Scripps Clinic - San Diego
Pennsylvania
- Lehigh Valley Topper Cancer Center Institute - Allentown
- Thomas Jefferson University - Philadelphia
- West Penn Hospital - Pittsburgh
New York
- Roswell Park Comprehensive Cancer Center - Buffalo
- Montefiore Medical Center - The Bronx
Ohio
- University of Cincinnati (UC) Physicians Company, LLC - Cincinnati
- Cleveland Clinic - Cleveland
Colorado
- Colorado Blood Cancer Institute - Denver
Georgia
- Augusta University Medical Center - Augusta
Indiana
- Indiana Blood and Marrow Transplantation - Indianapolis
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 270 participants |
| Start Date | 2023-05-09 |
| Est. Completion | 2031-06-30 |
| Phase | Phase 1 |
What NCT05826535 shows while recruiting
NCT05826535 is an interventional study that assigns participants to a tested intervention. The registered 270 participants enrollment target is mid-sized for trials with a published cap, above the 165-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (64% higher).
The record links to 4 conditions, with Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT05826535 names 20 study sites across 13 states, led by California, Pennsylvania, New York.
Frequently Asked Questions
What is clinical trial NCT05826535 about?
NCT05826535 is a clinical study titled "Study of LYL314 in Aggressive Large B-Cell Lymphoma". This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive large B-cell lymphoma.
What is the current status of trial NCT05826535?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 270 participants. The study started on 2023-05-09. Estimated completion is 2031-06-30.
What conditions does trial NCT05826535 study?
This clinical trial studies the following conditions: Non-Hodgkin Lymphoma, Large B-cell Lymphoma, Refractory Non-Hodgkin Lymphoma, Relapsed Non-Hodgkin Lymphoma.
What interventions are being tested in trial NCT05826535?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), LYL314 (DRUG).
Who is sponsoring clinical trial NCT05826535?
This trial is sponsored by Lyell Immunopharma, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05826535 being conducted?
This trial has 20 study locations across California, Colorado, Georgia, Indiana, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05826535's enrollment target sits among peer trials
270 17th of 106 higher than 90 of 106 other Non-Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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