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ClinicalTrials.gov 9 recruiting now official registry

Refractory Malignant Solid Neoplasm clinical trials

9 of 60 indexed Refractory Malignant Solid Neoplasm trials are currently recruiting.

60 US clinical trials · 9 currently recruiting

Refractory Malignant Solid Neoplasm is the subject of 60 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 45 of these trials.

The research picture

Refractory Malignant Solid Neoplasm has 60 registered US clinical trials, 9 of them open to new participants right now, about 15% of the total.

9
recruiting participants now
15%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
45
top sponsor: National Cancer Institute (NCI)
Phase 126Phase 233

Active & Recent Trials

60 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)

National Cancer Institute (NCI)

NCT06303167

ACTIVE NOT RECRUITING Phase 1 13 participants

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

National Cancer Institute (NCI)

NCT04197713

ACTIVE NOT RECRUITING Phase 2 10 participants

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

National Cancer Institute (NCI)

NCT06390826

ACTIVE NOT RECRUITING Phase 2 5 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)

National Cancer Institute (NCI)

NCT04439266

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

National Cancer Institute (NCI)

NCT04439253

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)

National Cancer Institute (NCI)

NCT04439357

COMPLETED Phase 1 83 participants

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT02159989

COMPLETED Phase 1 59 participants

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

Children's Oncology Group

NCT02323880

COMPLETED Phase 1 26 participants

Pepinemab in Treating Younger Patients With Recurrent, Relapsed, or Refractory Solid Tumors

Children's Oncology Group

NCT03320330

COMPLETED Phase 1 21 participants

Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

National Cancer Institute (NCI)

NCT02780804

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 33

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Malignant Solid Neoplasm Trial Landscape

60 indexed Refractory Malignant Solid Neoplasm studies · 9 recruiting (15%).

Phase mix: 0 late (III/IV) vs 59 early (I/II).

Top sponsor: National Cancer Institute (NCI) (45 trials), 8 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Malignant Solid Neoplasm?

PlainTrial tracks 60 US clinical trials for Refractory Malignant Solid Neoplasm, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.