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ClinicalTrials.gov 9 recruiting now official registry

Refractory Malignant Solid Neoplasm clinical trials

9 of 60 indexed Refractory Malignant Solid Neoplasm trials are currently recruiting.

60 US clinical trials · 9 currently recruiting

Refractory Malignant Solid Neoplasm is the subject of 60 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 45 of these trials.

The research picture

Refractory Malignant Solid Neoplasm has 60 registered US clinical trials, 9 of them open to new participants right now, about 15% of the total.

9
recruiting participants now
15%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
45
top sponsor: National Cancer Institute (NCI)
Phase 126Phase 233

Active & Recent Trials

60 total, page 1 of 2

RECRUITING Phase 1 95 participants

Studying TAK-243 in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT06223542

RECRUITING Phase 1 92 participants

AOH1996 for the Treatment of Refractory Solid Tumors

City of Hope Medical Center

NCT05227326

RECRUITING Phase 1 81 participants

Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

Children's Oncology Group

NCT06620302

RECRUITING Phase 1 63 participants

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Children's Oncology Group

NCT04870944

RECRUITING Phase 1 49 participants

Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

National Cancer Institute (NCI)

NCT05053971

RECRUITING Phase 1 42 participants

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Mayo Clinic

NCT06911008

RECRUITING Phase 1 38 participants

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

OHSU Knight Cancer Institute

NCT06320405

RECRUITING Phase 1 36 participants

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

University of Southern California

NCT05791448

RECRUITING Phase 1 18 participants

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Anusha Kalbasi

NCT04119024

ACTIVE NOT RECRUITING NA 1,284 participants

Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment

SWOG Cancer Research Network

NCT05455606

ACTIVE NOT RECRUITING Phase 1 173 participants

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT03217747

ACTIVE NOT RECRUITING Phase 1 96 participants

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT02079740

ACTIVE NOT RECRUITING Phase 1 93 participants

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

M.D. Anderson Cancer Center

NCT03065387

ACTIVE NOT RECRUITING Phase 2 70 participants

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

National Cancer Institute (NCI)

NCT04439175

ACTIVE NOT RECRUITING Phase 1 66 participants

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT02595931

ACTIVE NOT RECRUITING Phase 1 62 participants

Testing the Biological Effects of DS-8201a on Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT04294628

ACTIVE NOT RECRUITING Phase 2 53 participants

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

National Cancer Institute (NCI)

NCT04439344

ACTIVE NOT RECRUITING Phase 2 50 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)

National Cancer Institute (NCI)

NCT04439318

ACTIVE NOT RECRUITING Phase 1 50 participants

FID-007 in Treating Participants With Advanced Solid Tumors

University of Southern California

NCT03537690

ACTIVE NOT RECRUITING Phase 2 49 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

National Cancer Institute (NCI)

NCT06390865

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)

National Cancer Institute (NCI)

NCT06357975

ACTIVE NOT RECRUITING Phase 1 44 participants

Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors

M.D. Anderson Cancer Center

NCT05038839

ACTIVE NOT RECRUITING Phase 2 43 participants

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

National Cancer Institute (NCI)

NCT06390839

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing Afatinib as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol B)

National Cancer Institute (NCI)

NCT04439136

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing Palbociclib (PD-0332991) as a Potential Targeted Treatment in Cancers With CCND1, 2, 3 Amplification (MATCH-Subprotocol Z1B)

National Cancer Institute (NCI)

NCT04439201

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial

National Cancer Institute (NCI)

NCT05554341

ACTIVE NOT RECRUITING Phase 2 38 participants

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

National Cancer Institute (NCI)

NCT04439110

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

National Cancer Institute (NCI)

NCT06400238

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)

National Cancer Institute (NCI)

NCT06390852

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

National Cancer Institute (NCI)

NCT04439227

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)

National Cancer Institute (NCI)

NCT04439331

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)

National Cancer Institute (NCI)

NCT06357988

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

National Cancer Institute (NCI)

NCT04439188

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

National Cancer Institute (NCI)

NCT04439279

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F)

National Cancer Institute (NCI)

NCT05490771

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)

National Cancer Institute (NCI)

NCT06308822

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)

National Cancer Institute (NCI)

NCT04439123

ACTIVE NOT RECRUITING Phase 1 35 participants

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

National Cancer Institute (NCI)

NCT01303341

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)

National Cancer Institute (NCI)

NCT06385496

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)

National Cancer Institute (NCI)

NCT06400225

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)

National Cancer Institute (NCI)

NCT04439292

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

National Cancer Institute (NCI)

NCT06400251

ACTIVE NOT RECRUITING Phase 1 31 participants

Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors

National Cancer Institute (NCI)

NCT05071209

ACTIVE NOT RECRUITING Phase 1 30 participants

Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

National Cancer Institute (NCI)

NCT02535312

ACTIVE NOT RECRUITING Phase 2 24 participants

Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant Tumors

National Cancer Institute (NCI)

NCT03878095

ACTIVE NOT RECRUITING Phase 2 24 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

National Cancer Institute (NCI)

NCT04439149

ACTIVE NOT RECRUITING Phase 1 23 participants

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

M.D. Anderson Cancer Center

NCT04266912

ACTIVE NOT RECRUITING Phase 2 20 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

National Cancer Institute (NCI)

NCT06360575

ACTIVE NOT RECRUITING Phase 1 19 participants

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

National Cancer Institute (NCI)

NCT01364051

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

National Cancer Institute (NCI)

NCT06385483

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 33

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Malignant Solid Neoplasm Trial Landscape

60 indexed Refractory Malignant Solid Neoplasm studies · 9 recruiting (15%).

Phase mix: 0 late (III/IV) vs 59 early (I/II).

Top sponsor: National Cancer Institute (NCI) (45 trials), 8 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Malignant Solid Neoplasm?

PlainTrial tracks 60 US clinical trials for Refractory Malignant Solid Neoplasm, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.