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ClinicalTrials.gov 6 recruiting now official registry

Refractory B-Cell Non-Hodgkin Lymphoma clinical trials

6 of 16 indexed Refractory B-Cell Non-Hodgkin Lymphoma trials are currently recruiting.

16 US clinical trials · 6 currently recruiting

Refractory B-Cell Non-Hodgkin Lymphoma is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Refractory B-Cell Non-Hodgkin Lymphoma has 16 registered US clinical trials, 6 of them open to new participants right now, about 38% of the total.

6
recruiting participants now
38%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 113Phase 23

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 1 200 participants

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

ADC Therapeutics S.A.

NCT04970901

RECRUITING Phase 1 72 participants

CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Caribou Biosciences

NCT04637763

RECRUITING Phase 2 40 participants

Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies

University of Washington

NCT05453396

RECRUITING Phase 1 32 participants

Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma

National Cancer Institute (NCI)

NCT05272384

RECRUITING Phase 1 25 participants

CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

Mayo Clinic

NCT04892277

RECRUITING Phase 1 15 participants

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT05801913

ACTIVE NOT RECRUITING Phase 1 53 participants

A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

Fred Hutchinson Cancer Center

NCT03277729

ACTIVE NOT RECRUITING Phase 1 48 participants

Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment

National Cancer Institute (NCI)

NCT05627245

ACTIVE NOT RECRUITING Phase 1 43 participants

Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin Lymphoma

Barbara Ann Karmanos Cancer Institute

NCT03147885

ACTIVE NOT RECRUITING Phase 2 34 participants

Epcoritamab and Lenalidomide in Treating Patients With Refractory or Relapsed Immunodeficiency-Related Large B-Cell Lymphoma

Northwestern University

NCT06723457

ACTIVE NOT RECRUITING Phase 1 30 participants

R-ICE and Lenalidomide in Treating Patients With First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma

Academic and Community Cancer Research United

NCT02628405

ACTIVE NOT RECRUITING Phase 2 28 participants

Acalabrutinib + Liso-Cel In R/R Aggressive B-Cell Lymphomas

Patrick C. Johnson, MD

NCT05583149

ACTIVE NOT RECRUITING Phase 1 24 participants

Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin Lymphoma

National Cancer Institute (NCI)

NCT01695941

ACTIVE NOT RECRUITING Phase 1 13 participants

CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR)

Baylor College of Medicine

NCT03774654

ACTIVE NOT RECRUITING Phase 1 4 participants

An Early Phase Study of Venetoclax, Lenalidomide, and Rituximab/Hyaluronidase in Slow-Growing Lymphomas That Have Come Back After Treatment or Have Not Responded to Treatment

Thomas Jefferson University

NCT04447716

COMPLETED Phase 1 64 participants

Gemcitabine Hydrochloride, Clofarabine, and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

M.D. Anderson Cancer Center

NCT01701986

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory B-Cell Non-Hodgkin Lymphoma Trial Landscape

16 indexed Refractory B-Cell Non-Hodgkin Lymphoma studies · 6 recruiting (38%).

Phase mix: 0 late (III/IV) vs 16 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory B-Cell Non-Hodgkin Lymphoma?

PlainTrial tracks 16 US clinical trials for Refractory B-Cell Non-Hodgkin Lymphoma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory B-Cell Non-Hodgkin Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.