Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

NCT04970901 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to characterize the safety and tolerability of loncastuximab tesirine in combination with polatuzumab vedotin, glofitamab, or mosunetuzumab, and to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) for the combinations.

Interventions

  • DRUG Obinutuzumab
  • DRUG Mosunetuzumab
  • DRUG Glofitamab
  • DRUG Loncastuximab Tesirine
  • DRUG Polatuzumab Vedotin

Study Locations (20)

Florida

  • Sylvester Comprehensive Cancer Center — Miami
  • Miami Cancer Institute — Miami
  • Memorial Cancer Institute - Memorial Hospital West — Pembroke Pines

California

  • University of California San Francisco - Fresno Center for Medical Education and Research — Clovis
  • Scripps Health - Prebys Cancer Center — San Diego

Georgia

  • Winship Cancer Institute of Emory University — Atlanta
  • The Blood and Marrow Transplant Group of Georgia — Atlanta

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston
  • Dana-Farber Cancer Institute — Boston

Pennsylvania

  • Penn Medicine - Perelman Center for Advanced Medicine — Philadelphia
  • Allegheny Health Network - West Penn Hospital — Pittsburgh

Iowa

  • Mission Cancer + Blood - Mission Cancer Foundation — Des Moines

Minnesota

  • University of Minnesota — Minneapolis

New York

  • Columbia University Irving Medical Center — New York

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2022-06-17
Est. Completion 2027-10-29
Phase Phase 1

Sponsor

ADC Therapeutics S.A.

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04970901

The ClinicalTrials.gov registry entry for NCT04970901 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ADC Therapeutics S.A., which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Refractory B-Cell Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which Obinutuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04970901 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04970901 about?

NCT04970901 is a clinical study titled "A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)". The primary objective of this study is to characterize the safety and tolerability of loncastuximab tesirine in combination with polatuzumab vedotin, glofitamab, or mosunetuzumab, and to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) for the combinations.

What is the current status of trial NCT04970901?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 200 participants. The study started on 2022-06-17. Estimated completion is 2027-10-29.

What conditions does trial NCT04970901 study?

This clinical trial studies the following conditions: Refractory B-Cell Non-Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, Relapsed B-Cell Non-Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04970901?

The interventions under investigation include: Obinutuzumab (DRUG), Mosunetuzumab (DRUG), Glofitamab (DRUG), Loncastuximab Tesirine (DRUG), Polatuzumab Vedotin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04970901?

This trial is sponsored by ADC Therapeutics S.A., which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04970901 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Iowa, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial