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ClinicalTrials.gov 5 recruiting now official registry

Progressive Supranuclear Palsy clinical trials

5 of 20 indexed Progressive Supranuclear Palsy trials are currently recruiting.

20 US clinical trials · 5 currently recruiting

Progressive Supranuclear Palsy is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 2 of these trials.

The research picture

Progressive Supranuclear Palsy has 20 registered US clinical trials, 5 of them open to new participants right now, about 25% of the total.

5
recruiting participants now
25%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Massachusetts General Hospital
Phase 11Phase 24Phase 41

Active & Recent Trials

20 total, page 1 of 1

RECRUITING 2,000 participants

Modifiable Variables in Parkinsonism (MVP)

Bastyr University

NCT02194816

RECRUITING 360 participants

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03225144

RECRUITING NA 332 participants

A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy

Mayo Clinic

NCT02605785

RECRUITING 120 participants

Gait Analysis in Neurological Disease

Beth Israel Deaconess Medical Center

NCT02994719

RECRUITING 90 participants

Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

University of Texas Southwestern Medical Center

NCT03872102

ACTIVE NOT RECRUITING Phase 4 2,650 participants

Trial of Parkinson's And Zoledronic Acid

California Pacific Medical Center Research Institute

NCT03924414

ACTIVE NOT RECRUITING NA 632 participants

Community Outreach for Palliative Engagement -- Parkinson Disease

University of Rochester

NCT05222386

ACTIVE NOT RECRUITING 315 participants

Automated Imaging Differentiation of Parkinsonism

University of Florida

NCT05913687

ACTIVE NOT RECRUITING Phase 2 241 participants

A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)

Ferrer Internacional S.A.

NCT06355531

ACTIVE NOT RECRUITING NA 125 participants

Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)

University of Michigan

NCT05459753

ACTIVE NOT RECRUITING Phase 2 110 participants

AMX0035 and Progressive Supranuclear Palsy

Amylyx Pharmaceuticals

NCT06122662

ACTIVE NOT RECRUITING 85 participants

Remote Monitoring in Progressive Supranuclear Palsy (PSP)

Massachusetts General Hospital

NCT04753320

ACTIVE NOT RECRUITING 60 participants

A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes

Massachusetts General Hospital

NCT05956834

ACTIVE NOT RECRUITING NA 10 participants

Art Therapy in Progressive Supranuclear Palsy

Vanderbilt University Medical Center

NCT06588673

COMPLETED 485 participants

Speech Accessibility Project

University of Illinois at Urbana-Champaign

NCT05889260

COMPLETED Phase 2 313 participants

Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy

Allon Therapeutics

NCT01110720

COMPLETED NA 146 participants

Safety, Tolerability, and Efficacy of Two Different Oral Doses of NP031112 Versus Placebo in the Treatment of Patients With Mild-to-Moderate Progressive Supranuclear Palsy

Noscira

NCT01049399

COMPLETED NA 56 participants

In-Home Care for Patients With PSP and Related Disorders

Rush University Medical Center

NCT03552484

COMPLETED Phase 1 6 participants

Young Plasma Transfusions for Progressive Supranuclear Palsy

University of California, San Francisco

NCT02460731

COMPLETED Phase 2

Effects of Coenzyme Q10 in PSP and CBD

Lahey Clinic

NCT00532571

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Progressive Supranuclear Palsy Trial Landscape

20 indexed Progressive Supranuclear Palsy studies · 5 recruiting (25%).

Phase mix: 1 late (III/IV) vs 5 early (I/II).

Top sponsor: Massachusetts General Hospital (2 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Progressive Supranuclear Palsy?

PlainTrial tracks 20 US clinical trials for Progressive Supranuclear Palsy, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Progressive Supranuclear Palsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.