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Progressive Supranuclear Palsy clinical trials
5 of 20 indexed Progressive Supranuclear Palsy trials are currently recruiting.
20 US clinical trials · 5 currently recruiting
Progressive Supranuclear Palsy is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 2 of these trials.
The research picture
Progressive Supranuclear Palsy has 20 registered US clinical trials, 5 of them open to new participants right now, about 25% of the total.
- 5
- recruiting participants now
- 25%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
20 total, page 1 of 1
Modifiable Variables in Parkinsonism (MVP)
Bastyr University
NCT02194816
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03225144
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
Mayo Clinic
NCT02605785
Gait Analysis in Neurological Disease
Beth Israel Deaconess Medical Center
NCT02994719
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
University of Texas Southwestern Medical Center
NCT03872102
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Community Outreach for Palliative Engagement -- Parkinson Disease
University of Rochester
NCT05222386
Automated Imaging Differentiation of Parkinsonism
University of Florida
NCT05913687
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)
Ferrer Internacional S.A.
NCT06355531
Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)
University of Michigan
NCT05459753
AMX0035 and Progressive Supranuclear Palsy
Amylyx Pharmaceuticals
NCT06122662
Remote Monitoring in Progressive Supranuclear Palsy (PSP)
Massachusetts General Hospital
NCT04753320
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
Massachusetts General Hospital
NCT05956834
Art Therapy in Progressive Supranuclear Palsy
Vanderbilt University Medical Center
NCT06588673
Speech Accessibility Project
University of Illinois at Urbana-Champaign
NCT05889260
Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy
Allon Therapeutics
NCT01110720
Safety, Tolerability, and Efficacy of Two Different Oral Doses of NP031112 Versus Placebo in the Treatment of Patients With Mild-to-Moderate Progressive Supranuclear Palsy
Noscira
NCT01049399
In-Home Care for Patients With PSP and Related Disorders
Rush University Medical Center
NCT03552484
Young Plasma Transfusions for Progressive Supranuclear Palsy
University of California, San Francisco
NCT02460731
Effects of Coenzyme Q10 in PSP and CBD
Lahey Clinic
NCT00532571
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Progressive Supranuclear Palsy Trial Landscape
20 indexed Progressive Supranuclear Palsy studies · 5 recruiting (25%).
Phase mix: 1 late (III/IV) vs 5 early (I/II).
Top sponsor: Massachusetts General Hospital (2 trials), 9 others listed. 20 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Progressive Supranuclear Palsy?
PlainTrial tracks 20 US clinical trials for Progressive Supranuclear Palsy, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Progressive Supranuclear Palsy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.