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Primary Sclerosing Cholangitis clinical trials
15 of 24 indexed Primary Sclerosing Cholangitis trials are currently recruiting.
24 US clinical trials · 15 currently recruiting
Primary Sclerosing Cholangitis is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 4 of these trials.
The research picture
Primary Sclerosing Cholangitis has 24 registered US clinical trials, 15 of them open to new participants right now, about 63% of the total.
- 15
- recruiting participants now
- 63%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Mayo Clinic
Active & Recent Trials
24 total, page 1 of 1
Biobank for Cholestatic Liver Diseases.
Mayo Clinic
NCT03445585
Primary Sclerosing Cholangitis in Children
Arbor Research Collaborative for Health
NCT04181138
A-LiNK: Improving Outcomes in Autoimmune Liver Disease
Children's Hospital Medical Center, Cincinnati
NCT05750498
Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients
Mayo Clinic
NCT04753996
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Sacramento Pediatric Gastroenterology
NCT02137668
MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease
Children's Hospital Medical Center, Cincinnati
NCT03178630
Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04685200
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
Takeda
NCT07229911
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
Children's Hospital Medical Center, Cincinnati
NCT03175471
Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation
Mayo Clinic
NCT06905054
Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC
University of Minnesota
NCT06197308
Detoxification of the Liver In PSC (Dolphin)
Brigham and Women's Hospital
NCT05835505
Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis.
Aparna Goel
NCT05295680
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Stanford University
NCT05912387
A Study of SIPLIZUMAB in AILD and LT Patients
Elizabeth C. Verna
NCT06455280
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
Mirum Pharmaceuticals
NCT04663308
A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.
Ipsen
NCT05627362
Quality of Life in Patients With Primary Sclerosing Cholangitis
Duke University
NCT02712736
A Study of NGM282 in Patients With Primary Sclerosing Cholangitis
NGM Biopharmaceuticals
NCT02704364
Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Stanford University
NCT01802073
Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis
Brigham and Women's Hospital
NCT03561584
Cholangioscopy Using Narrow Band Imaging (NBI) in Patients With Primary Sclerosing Cholangitis (PSC) Undergoing Endoscopic Retrograde Cholangiopancreatogram (ERCP)
Mayo Clinic
NCT00951327
A Pilot Study Examining Diet in Primary Sclerosing Cholangitis
Brigham and Women's Hospital
NCT04678219
A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis
University of Minnesota
NCT02464020
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 7 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Primary Sclerosing Cholangitis Trial Landscape
24 indexed Primary Sclerosing Cholangitis studies · 15 recruiting (63%).
Phase mix: 1 late (III/IV) vs 13 early (I/II).
Top sponsor: Mayo Clinic (4 trials), 9 others listed. 24 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Primary Sclerosing Cholangitis?
PlainTrial tracks 24 US clinical trials for Primary Sclerosing Cholangitis, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Primary Sclerosing Cholangitis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.