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ClinicalTrials.gov 15 recruiting now official registry

Primary Sclerosing Cholangitis clinical trials

15 of 24 indexed Primary Sclerosing Cholangitis trials are currently recruiting.

24 US clinical trials · 15 currently recruiting

Primary Sclerosing Cholangitis is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 4 of these trials.

The research picture

Primary Sclerosing Cholangitis has 24 registered US clinical trials, 15 of them open to new participants right now, about 63% of the total.

15
recruiting participants now
63%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: Mayo Clinic
Phase 16Phase 27Phase 31

Active & Recent Trials

24 total, page 1 of 1

RECRUITING 9,150 participants

Biobank for Cholestatic Liver Diseases.

Mayo Clinic

NCT03445585

RECRUITING 1,000 participants

Primary Sclerosing Cholangitis in Children

Arbor Research Collaborative for Health

NCT04181138

RECRUITING 800 participants

A-LiNK: Improving Outcomes in Autoimmune Liver Disease

Children's Hospital Medical Center, Cincinnati

NCT05750498

RECRUITING 300 participants

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Mayo Clinic

NCT04753996

RECRUITING Phase 1 200 participants

Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin

Sacramento Pediatric Gastroenterology

NCT02137668

RECRUITING 150 participants

MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease

Children's Hospital Medical Center, Cincinnati

NCT03178630

RECRUITING 143 participants

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT04685200

RECRUITING Phase 1 134 participants

A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)

Takeda

NCT07229911

RECRUITING 115 participants

MRI Based Biomarkers in Pediatric Autoimmune Liver Disease

Children's Hospital Medical Center, Cincinnati

NCT03175471

RECRUITING Phase 2 80 participants

Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation

Mayo Clinic

NCT06905054

RECRUITING Early Phase 1 28 participants

Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC

University of Minnesota

NCT06197308

RECRUITING Phase 2 28 participants

Detoxification of the Liver In PSC (Dolphin)

Brigham and Women's Hospital

NCT05835505

RECRUITING Phase 2 24 participants

Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis.

Aparna Goel

NCT05295680

RECRUITING Early Phase 1 15 participants

Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study

Stanford University

NCT05912387

RECRUITING Phase 1 8 participants

A Study of SIPLIZUMAB in AILD and LT Patients

Elizabeth C. Verna

NCT06455280

ACTIVE NOT RECRUITING Phase 2 182 participants

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Mirum Pharmaceuticals

NCT04663308

ACTIVE NOT RECRUITING Phase 2 68 participants

A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.

Ipsen

NCT05627362

COMPLETED NA 102 participants

Quality of Life in Patients With Primary Sclerosing Cholangitis

Duke University

NCT02712736

COMPLETED Phase 2 62 participants

A Study of NGM282 in Patients With Primary Sclerosing Cholangitis

NGM Biopharmaceuticals

NCT02704364

COMPLETED Phase 3 34 participants

Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects

Stanford University

NCT01802073

COMPLETED Phase 2 32 participants

Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis

Brigham and Women's Hospital

NCT03561584

COMPLETED 30 participants

Cholangioscopy Using Narrow Band Imaging (NBI) in Patients With Primary Sclerosing Cholangitis (PSC) Undergoing Endoscopic Retrograde Cholangiopancreatogram (ERCP)

Mayo Clinic

NCT00951327

COMPLETED NA 20 participants

A Pilot Study Examining Diet in Primary Sclerosing Cholangitis

Brigham and Women's Hospital

NCT04678219

COMPLETED Phase 1 8 participants

A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis

University of Minnesota

NCT02464020

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Primary Sclerosing Cholangitis Trial Landscape

24 indexed Primary Sclerosing Cholangitis studies · 15 recruiting (63%).

Phase mix: 1 late (III/IV) vs 13 early (I/II).

Top sponsor: Mayo Clinic (4 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Primary Sclerosing Cholangitis?

PlainTrial tracks 24 US clinical trials for Primary Sclerosing Cholangitis, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Primary Sclerosing Cholangitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.