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Primary Open Angle Glaucoma: early-phase trial registry
10 of 20 indexed Primary Open Angle Glaucoma trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #848 of 28,707 conditions by registered trial count.
20 US clinical trials · 10 currently recruiting · #848 of 28,707 conditions by registered trial count
Primary Open Angle Glaucoma: 20 US clinical trials tracked, 10 recruiting.
Primary Open Angle Glaucoma is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 2 of these trials.
Enrollment posture brief
Registry condition primary-open-angle-glaucoma
OPEN 10 | RECR 50% | LATE 1 | EARLY 7 | RANK #848 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)
Primary Open Angle Glaucoma lists 10 open slots (50% of 20 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Primary Open Angle Glaucoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Primary Open Angle Glaucoma is recruiting above its size-band peers.
10 of 20 indexed trials (50%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Primary Open Angle Glaucoma trials is spread across many organizations.
University of Alabama at Birmingham accounts for 2 of 20 trials (10%). 19 distinct sponsors appear on at least one study for this condition label.
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Typical Primary Open Angle Glaucoma enrolment sits around 129 participants.
Median target enrolment is 129 among the 20 trials that report a genuine target (sentinel values excluded). 8 of those (40%) plan for fewer than 100 participants.
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Primary Open Angle Glaucoma research is mostly interventional.
14 interventional and 6 observational studies make up this index (70% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
20 total, page 1 of 1
Diagnostic Innovations in Glaucoma Study
University of California, San Diego
NCT00221897
Hydrus® Microstent New Enrollment Post-Approval Study
Alcon Research
NCT04553523
A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma
AbbVie
NCT06822738
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
Sanoculis
NCT06313749
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
University of Alabama at Birmingham
NCT04396002
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
Nova Eye
NCT05564091
DSLT for Reducing Medication in Glaucoma
The Eye Institute of West Florida
NCT07390890
A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients
Brian Shafer
NCT07076303
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
Amydis
NCT06223048
Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial
59th Medical Wing
NCT05844384
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
Columbia University
NCT05695027
Advanced Glaucoma Progression Study
University of California, Los Angeles
NCT01742819
Impact of Glaucoma and Visual Field Loss on Life Space
University of Alabama at Birmingham
NCT03673644
Study to Assess the Efficacy, Safety and Tolerability of AKB-9778 Ophthalmic Solution as and Adjunct to Latanoprost in Patients With Ocular Hypertension or Open Angle Glaucoma
EyePoint Pharmaceuticals
NCT04405245
Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma
Bausch & Lomb Incorporated
NCT00441883
Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
Allergan
NCT01110499
Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes
Ivantis
NCT02023242
Ahmed Glaucoma Valve Surgery With Mitomycin-C
University of California, San Francisco
NCT02805257
Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension).
Qlaris Bio
NCT04830397
The Effects of Visior on Ocular Hemodynamics
Visior Technologies
NCT02959593
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Primary Open Angle Glaucoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Primary Open Angle Glaucoma trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Primary Open Angle Glaucoma page
20 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 10 Primary Open Angle Glaucoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Alabama at Birmingham sponsors the most Primary Open Angle Glaucoma trials on record, review their full trial history before evaluating a specific study. See University of Alabama at Birmingham's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Primary Open Angle Glaucoma condition card totals 20 registered trials; most-linked intervention Cataract surgery; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.