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Primary Open Angle Glaucoma clinical trials
10 of 20 indexed Primary Open Angle Glaucoma trials are currently recruiting.
20 US clinical trials · 10 currently recruiting
Primary Open Angle Glaucoma is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 2 of these trials.
The research picture
Primary Open Angle Glaucoma has 20 registered US clinical trials, 10 of them open to new participants right now, about 50% of the total.
- 10
- recruiting participants now
- 50%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: University of Alabama at Birmingham
Active & Recent Trials
20 total, page 1 of 1
Diagnostic Innovations in Glaucoma Study
University of California, San Diego
NCT00221897
Hydrus® Microstent New Enrollment Post-Approval Study
Alcon Research
NCT04553523
A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma
AbbVie
NCT06822738
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
Sanoculis
NCT06313749
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
University of Alabama at Birmingham
NCT04396002
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
Nova Eye
NCT05564091
DSLT for Reducing Medication in Glaucoma
The Eye Institute of West Florida
NCT07390890
A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients
Brian Shafer
NCT07076303
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
Amydis
NCT06223048
Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial
59th Medical Wing
NCT05844384
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
Columbia University
NCT05695027
Advanced Glaucoma Progression Study
University of California, Los Angeles
NCT01742819
Impact of Glaucoma and Visual Field Loss on Life Space
University of Alabama at Birmingham
NCT03673644
Study to Assess the Efficacy, Safety and Tolerability of AKB-9778 Ophthalmic Solution as and Adjunct to Latanoprost in Patients With Ocular Hypertension or Open Angle Glaucoma
EyePoint Pharmaceuticals
NCT04405245
Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma
Bausch & Lomb Incorporated
NCT00441883
Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
Allergan
NCT01110499
Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes
Ivantis
NCT02023242
Ahmed Glaucoma Valve Surgery With Mitomycin-C
University of California, San Francisco
NCT02805257
Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension).
Qlaris Bio
NCT04830397
The Effects of Visior on Ocular Hemodynamics
Visior Technologies
NCT02959593
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Primary Open Angle Glaucoma Trial Landscape
20 indexed Primary Open Angle Glaucoma studies · 10 recruiting (50%).
Phase mix: 1 late (III/IV) vs 7 early (I/II).
Top sponsor: University of Alabama at Birmingham (2 trials), 9 others listed. 20 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Primary Open Angle Glaucoma?
PlainTrial tracks 20 US clinical trials for Primary Open Angle Glaucoma, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Primary Open Angle Glaucoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.