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ClinicalTrials.gov 10 recruiting now official registry

Primary Open Angle Glaucoma clinical trials

10 of 20 indexed Primary Open Angle Glaucoma trials are currently recruiting.

20 US clinical trials · 10 currently recruiting

Primary Open Angle Glaucoma is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 2 of these trials.

The research picture

Primary Open Angle Glaucoma has 20 registered US clinical trials, 10 of them open to new participants right now, about 50% of the total.

10
recruiting participants now
50%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: University of Alabama at Birmingham
Phase 27Phase 31

Active & Recent Trials

20 total, page 1 of 1

RECRUITING 3,000 participants

Diagnostic Innovations in Glaucoma Study

University of California, San Diego

NCT00221897

RECRUITING NA 545 participants

Hydrus® Microstent New Enrollment Post-Approval Study

Alcon Research

NCT04553523

RECRUITING Phase 3 130 participants

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

AbbVie

NCT06822738

RECRUITING NA 129 participants

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Sanoculis

NCT06313749

RECRUITING 100 participants

Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

University of Alabama at Birmingham

NCT04396002

RECRUITING NA 78 participants

Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma

Nova Eye

NCT05564091

RECRUITING 60 participants

DSLT for Reducing Medication in Glaucoma

The Eye Institute of West Florida

NCT07390890

RECRUITING 60 participants

A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients

Brian Shafer

NCT07076303

RECRUITING Phase 2 50 participants

A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma

Amydis

NCT06223048

RECRUITING NA 30 participants

Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial

59th Medical Wing

NCT05844384

ACTIVE NOT RECRUITING Phase 2 250 participants

Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study

Columbia University

NCT05695027

ACTIVE NOT RECRUITING 150 participants

Advanced Glaucoma Progression Study

University of California, Los Angeles

NCT01742819

ACTIVE NOT RECRUITING 88 participants

Impact of Glaucoma and Visual Field Loss on Life Space

University of Alabama at Birmingham

NCT03673644

COMPLETED Phase 2 194 participants

Study to Assess the Efficacy, Safety and Tolerability of AKB-9778 Ophthalmic Solution as and Adjunct to Latanoprost in Patients With Ocular Hypertension or Open Angle Glaucoma

EyePoint Pharmaceuticals

NCT04405245

COMPLETED Phase 2 176 participants

Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma

Bausch & Lomb Incorporated

NCT00441883

COMPLETED Phase 2 163 participants

Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT01110499

COMPLETED NA 152 participants

Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes

Ivantis

NCT02023242

COMPLETED Phase 2 119 participants

Ahmed Glaucoma Valve Surgery With Mitomycin-C

University of California, San Francisco

NCT02805257

COMPLETED Phase 2 84 participants

Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension).

Qlaris Bio

NCT04830397

COMPLETED NA 35 participants

The Effects of Visior on Ocular Hemodynamics

Visior Technologies

NCT02959593

Phase Distribution

PhaseTrial count
Phase 2 7
Phase 3 1

Top Sponsors

Ivantis 1 trials
Allergan 1 trials
Nova Eye 1 trials
Sanoculis 1 trials
Brian Shafer 1 trials
Qlaris Bio 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Primary Open Angle Glaucoma Trial Landscape

20 indexed Primary Open Angle Glaucoma studies · 10 recruiting (50%).

Phase mix: 1 late (III/IV) vs 7 early (I/II).

Top sponsor: University of Alabama at Birmingham (2 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Primary Open Angle Glaucoma?

PlainTrial tracks 20 US clinical trials for Primary Open Angle Glaucoma, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Primary Open Angle Glaucoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.