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NCT01742819 · ClinicalTrials.gov registry record
Advanced Glaucoma Progression Study
A clinical trial of Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma, sponsored by University of California, Los Angeles.
- Active
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT01742819: Active study of Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma, sponsored by University of California, Los Angeles.
NCT01742819 is a study of Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma that is active but no longer recruiting, run by University of California, Los Angeles. The registered enrollment target is 150 participants, below the 286-participant average among 19 other Primary Open Angle Glaucoma trials with a reported enrollment target (48% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01742819, a study of Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma, is active but no longer recruiting, sponsored by University of California, Los Angeles.
- ACTIVE NOT RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
Glaucoma is one of the leading causes of blindness in the world. The key to prevention of visual loss from glaucoma is early detection of the disease or its progression and timely treatment. The proposed study will investigate the role of various tests in improving detection of disease progression in advanced glaucoma. Evaluation of the peripheral field of vision (visual field examination) remains the current standard for detection of progression in glaucoma. However, there is a lot of variability or inconsistency in eyes with advanced glaucoma, which could make it difficult to detect worsening of glaucoma with visual fields. The optic nerve demonstrates significant damage in such eyes and hence oftentimes repeat imaging of the optic nerve head is not helpful for detection of change. Therefore, imaging of the central retina (the innermost sensitive tissue lining the inside of the eye), called macula, has been proposed to supplant imaging of the nerve in eyes with severe glaucoma. The macula aids in detailed central vision. Since the macular retinal neural cells are the last ones to be affected in glaucoma, measurement of macular retinal thickness could provide significant information with regard to the course of glaucoma. In the proposed study, glaucoma patients will be tested and followed with various measurements done with newer versions of optical coherence tomography (OCT) imaging and visual field machines. The patients will undergo repeat imaging and visual field testing every 6 months over the course of 5 years. Rates of change will be estimated. We will explore if changes in various outcome measures derived from imaging are correlated with the corresponding visual field changes in glaucoma, and whether the former can be used as an alternative method for detecting simultaneous or subsequent glaucoma progression. The hypothesis for this proposed research is that macular OCT parameters are valid structural measures that can be used especially in advanced disease
Primary Outcome
Worsening of the MD and/or increased visual field loss within the central 10 degrees of the field.
Conditions Studied
Study Locations (1)
California
- UCLA Jules Stein Eye Institute - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2012-05 |
| Est. Completion | 2025-12 |
What the registry record for NCT01742819 still lists
NCT01742819 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 286-participant average among 19 other Primary Open Angle Glaucoma trials with a reported enrollment target (48% lower).
The record links to 3 conditions, with Primary Open Angle Glaucoma appearing as the primary indexed condition, and to 0 interventions.
NCT01742819 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT01742819 about?
NCT01742819 is a clinical study titled "Advanced Glaucoma Progression Study". Glaucoma is one of the leading causes of blindness in the world. The key to prevention of visual loss from glaucoma is early detection of the disease or its progression and timely treatment. The proposed study will investigate the role of various tests in improving detection of disease progression i...
What is the current status of trial NCT01742819?
This trial is currently active not recruiting. The enrollment target is 150 participants. The study started on 2012-05. Estimated completion is 2025-12.
What conditions does trial NCT01742819 study?
This clinical trial studies the following conditions: Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma, Chronic Angle Closure Glaucoma.
Who is sponsoring clinical trial NCT01742819?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01742819 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01742819's enrollment target sits among peer trials
150 8th of 19 higher than 12 of 19 other Primary Open Angle Glaucoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Primary Open Angle Glaucoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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