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ClinicalTrials.gov 9 recruiting now official registry

Primary Central Nervous System Lymphoma clinical trials

9 of 13 indexed Primary Central Nervous System Lymphoma trials are currently recruiting.

13 US clinical trials · 9 currently recruiting

Primary Central Nervous System Lymphoma is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 2 of these trials.

The research picture

Primary Central Nervous System Lymphoma has 13 registered US clinical trials, 9 of them open to new participants right now, about 69% of the total.

9
recruiting participants now
69%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Dana-Farber Cancer Institute
Phase 19Phase 24

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 1 93 participants

Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma

National Cancer Institute (NCI)

NCT02203526

RECRUITING Phase 1 37 participants

Pembrolizumab, Ibrutinib and Rituximab in PCNSL

Dana-Farber Cancer Institute

NCT04421560

RECRUITING Phase 1 35 participants

Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma

James Rubenstein

NCT05351593

RECRUITING Phase 2 28 participants

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

Providence Health & Services

NCT06175000

RECRUITING Phase 1 26 participants

A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)

Memorial Sloan Kettering Cancer Center

NCT07082868

RECRUITING Phase 2 25 participants

Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

Lakshmi Nayak, MD

NCT04906096

RECRUITING Phase 1 20 participants

Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma

City of Hope Medical Center

NCT06922604

RECRUITING Phase 2 15 participants

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

Baptist Health South Florida

NCT05681195

RECRUITING Phase 1 15 participants

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

Dana-Farber Cancer Institute

NCT06475235

ACTIVE NOT RECRUITING Phase 1 25 participants

Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma

Washington University School of Medicine

NCT04462328

COMPLETED Phase 1 271 participants

Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma

Celgene

NCT01421524

COMPLETED Phase 1 39 participants

Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

TG Therapeutics

NCT01647971

COMPLETED Phase 2 4 participants

Buparlisib (BKM120) In Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Recurrent/Refractory Secondary Central Nervous System Lymphoma (SCNSL)

Memorial Sloan Kettering Cancer Center

NCT02301364

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Primary Central Nervous System Lymphoma Trial Landscape

13 indexed Primary Central Nervous System Lymphoma studies · 9 recruiting (69%).

Phase mix: 0 late (III/IV) vs 13 early (I/II).

Top sponsor: Dana-Farber Cancer Institute (2 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Primary Central Nervous System Lymphoma?

PlainTrial tracks 13 US clinical trials for Primary Central Nervous System Lymphoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Primary Central Nervous System Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.