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ClinicalTrials.gov 5 recruiting now early-phase tilt small index

Post-Traumatic Headache: early-phase trial registry

5 of 12 indexed Post-Traumatic Headache trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,429 of 28,707 conditions by registered trial count.

12 US clinical trials · 5 currently recruiting · #1,429 of 28,707 conditions by registered trial count

Post-Traumatic Headache: 12 US clinical trials tracked, 5 recruiting.

Post-Traumatic Headache is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Henry M. Jackson Foundation for the Advancement of Military Medicine, running 2 of these trials.

Enrollment posture brief

Registry condition post-traumatic-headache

OPEN 5 | RECR 42% | LATE 2 | EARLY 4 | RANK #1429 | SPON 2

Nearest open-share peer: Adiposity (42% recruiting · 12 trials)

Post-Traumatic Headache (thi…42%Acute Myeloid Leukemia in Re41.7%Adenocarcinoma of the Rectum41.7%Adherence, Patient16.7%Accelerated Phase Chronic My0%
Open-enrollment share among volume-matched conditions near Post-Traumatic Headache

Post-Traumatic Headache lists 5 open slots (42% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Post-Traumatic Headache on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Post-Traumatic Headache is recruiting below its size-band peers.

    5 of 12 indexed trials (41.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Post-Traumatic Headache research.

    Henry M. Jackson Foundation for the Advancement of Military Medicine accounts for 2 of 12 trials (16.7%). 8 distinct sponsors appear on at least one study for this condition label.

  3. Typical Post-Traumatic Headache enrolment sits around 160 participants.

    Median target enrolment is 160 among the 12 trials that report a genuine target (sentinel values excluded). 4 of those (33.3%) plan for fewer than 100 participants.

  4. Post-Traumatic Headache research is mostly interventional.

    11 interventional and 1 observational studies make up this index (91.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 23Phase 31Phase 41

Open and recent trials

12 total, page 1 of 1

RECRUITING NA 525 participants

Multisite Advancement of Research on Chronic Posttraumatic Headache

The University of Texas Health Science Center at San Antonio

NCT05620719

RECRUITING Phase 2 404 participants

Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT05049057

RECRUITING Phase 2 175 participants

Ketamine, SGB and Combination Treatment for TBI

Northwestern University

NCT06608277

RECRUITING NA 40 participants

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Walter Reed National Military Medical Center

NCT05414708

RECRUITING Phase 1 12 participants

Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

Yale University

NCT06069791

ACTIVE NOT RECRUITING NA 100 participants

e-CBT DTx for Post Traumatic Headaches in Adults With History of TBI

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT06669780

COMPLETED NA 193 participants

Cognitive-Behavior Therapy for Posttraumatic Headache

The University of Texas Health Science Center at San Antonio

NCT02419131

COMPLETED Phase 4 162 participants

Dexamethasone for Post Traumatic Headache

Montefiore Medical Center

NCT04799015

COMPLETED Phase 3 160 participants

Metoclopramide for Post Traumatic Headache

Montefiore Medical Center

NCT03220958

COMPLETED 101 participants

Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache

Mayo Clinic

NCT04369729

COMPLETED NA 34 participants

Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology

University of Illinois at Urbana-Champaign

NCT03674398

COMPLETED Phase 2 6 participants

Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH

Mayo Clinic

NCT04098250

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 3 1
Phase 4 1

Named interventions

Most-linked intervention names on Post-Traumatic Headache records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Erenumab Drug
1 trials
Behavioral Headache Therapy Behavioral
1 trials
Exercise only Behavioral
1 trials
Exercise+CT Behavioral
1 trials
Metoclopramide 10mg Drug
1 trials
Ammo Sham Device
1 trials
AMMO PTH DTx Device
1 trials
Metoclopramide Drug
1 trials

US sites by state

Facility locations filed on Post-Traumatic Headache trials. A trial with sites in several states counts in each.

Maryland 4 trials
Texas 3 trials
Minnesota 3 trials
New York 2 trials
North Carolina 2 trials
Illinois 2 trials
Florida 2 trials
Arizona 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Post-Traumatic Headache page

12 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Post-Traumatic Headache condition card totals 12 registered trials; most-linked intervention Erenumab; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.