Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Multisite Advancement of Research on Chronic Posttraumatic Headache
NCT05620719 · View on ClinicalTrials.gov ↗
Study Summary
Posttraumatic headache (PTH) is a common and highly disabling consequence of traumatic brain injury (TBI) in U.S. military service members and veterans. Cognitive Behavioral Therapy for PTH has been shown to significantly improve disability outcomes in veterans with persistent PTH when delivered in-person. Telemedicine platforms can dramatically increase access to evidence-based care. However, whether CBT for PTH retains its effectiveness when delivered through a telemedicine platform has yet to be established. The purpose of this 3-arm randomized clinical trial is to compare Clinic-based Cognitive-Behavioral Therapy (CCBT) to Telemedicine-based Cognitive Behavioral Therapy (TCBT) and to treatment as usual (TAU) in 525 service members and veterans with chronic posttraumatic headaches (PTH) at 4 VA medical centers\* and 3 military treatment facilities across the U.S. Participants will be assessed for headache-related disability, headache experience, and psychiatric comorbidities across multiple time points. \*VA Palo Alto Health Care System is temporarily randomizing into TAU and TCBT only.
Conditions Studied
Interventions
- OTHER Treatment as Usual
- BEHAVIORAL Cognitive Behavioral Therapy for Posttraumatic Headache
- OTHER Telemedicine-based Cognitive Behavioral Therapy (TCBT)
Study Locations (8)
Texas
- Carl R. Darnall Army Medical Center (Fort Cavazos) — Killeen
- South Texas Veterans Health Care System — San Antonio
- Brooke Army Medical Center — San Antonio
California
- VA Greater Los Angeles Healthcare System — Los Angeles
- VA Palo Alto Health Care System — Palo Alto
Hawaii
- Tripler Army Medical Center (Desmond Doss Health Clinic, Schofield Barracks) — Honolulu
Maryland
- Walter Reed National Military Medical Center — Bethesda
Minnesota
- Minneapolis VA Health Care System — Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 525 participants |
| Start Date | 2023-08-24 |
| Est. Completion | 2027-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05620719
The ClinicalTrials.gov registry entry for NCT05620719 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 525 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The University of Texas Health Science Center at San Antonio, which has 481 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Posttraumatic Headache appearing as the primary indexed condition, and to 3 interventions — of which Treatment as Usual is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05620719 reports 8 study locations spanning 5 distinct geographic areas — top geographies include Texas, California, Hawaii. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05620719 about?
NCT05620719 is a clinical study titled "Multisite Advancement of Research on Chronic Posttraumatic Headache". Posttraumatic headache (PTH) is a common and highly disabling consequence of traumatic brain injury (TBI) in U.S. military service members and veterans. Cognitive Behavioral Therapy for PTH has been shown to significantly improve disability outcomes in veterans with persistent PTH when delivered in-...
What is the current status of trial NCT05620719?
This trial is currently recruiting. It is a NA study. The enrollment target is 525 participants. The study started on 2023-08-24. Estimated completion is 2027-08.
What conditions does trial NCT05620719 study?
This clinical trial studies the following conditions: Posttraumatic Headache. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05620719?
The interventions under investigation include: Treatment as Usual (OTHER), Cognitive Behavioral Therapy for Posttraumatic Headache (BEHAVIORAL), Telemedicine-based Cognitive Behavioral Therapy (TCBT) (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05620719?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 481 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05620719 being conducted?
This trial has 8 study locations across California, Hawaii, Maryland, Minnesota, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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