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ClinicalTrials.gov 11 recruiting now official registry

Platinum-resistant Ovarian Cancer clinical trials

11 of 18 indexed Platinum-resistant Ovarian Cancer trials are currently recruiting.

18 US clinical trials · 11 currently recruiting

Platinum-resistant Ovarian Cancer is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Mersana Therapeutics, running 3 of these trials.

The research picture

Platinum-resistant Ovarian Cancer has 18 registered US clinical trials, 11 of them open to new participants right now, about 61% of the total.

11
recruiting participants now
61%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
3
top sponsor: Mersana Therapeutics
Phase 111Phase 24Phase 33

Active & Recent Trials

18 total, page 1 of 1

RECRUITING Phase 1 265 participants

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

Whitehawk Therapeutics

NCT07470853

RECRUITING Phase 1 226 participants

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

Whitehawk Therapeutics

NCT07444814

RECRUITING Phase 3 186 participants

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Genelux Corporation

NCT05281471

RECRUITING Phase 1 100 participants

A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer

Stemline Therapeutics

NCT07226427

RECRUITING Phase 1 80 participants

A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

Context Therapeutics

NCT06515613

RECRUITING Phase 2 60 participants

A Study of Lorigerlimab in Participants With Advanced Solid Tumors

MacroGenics

NCT06730347

RECRUITING Phase 2 40 participants

A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer

Cybrexa Therapeutics

NCT06315491

RECRUITING Phase 1 30 participants

A Study to Evaluate the Safety and Efficacy of OPB-101 in Platinum-resistant Ovarian Cancer

Outpace Bio

NCT07030907

RECRUITING Phase 1 29 participants

Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.

TILT Biotherapeutics

NCT05271318

RECRUITING Phase 2 20 participants

A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer

ImmunityBio

NCT06710288

RECRUITING Phase 1 18 participants

Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer

Dana-Farber Cancer Institute

NCT06321484

ACTIVE NOT RECRUITING Phase 3 530 participants

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

Genmab

NCT06619236

ACTIVE NOT RECRUITING Phase 1 523 participants

First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b

Mersana Therapeutics

NCT03319628

ACTIVE NOT RECRUITING Phase 2 380 participants

Trial of NP-G2-044 (Prilukae) Combined With PLD for Treatment of Platinum-Resistant Ovarian Cancer (ULTIMUS-1)

Novita Pharmaceuticals

NCT07109414

ACTIVE NOT RECRUITING Phase 1 320 participants

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Ascendis Pharma Oncology Division A/S

NCT05081609

ACTIVE NOT RECRUITING Phase 3 150 participants

Cancer Stem Cell Assay Directed Chemotherapy in Recurrent Platinum Resistant Ovarian Cancer

Cordgenics

NCT03949283

COMPLETED Phase 1 142 participants

First-in-Human Dose Expansion Study of XMT-1536 in Cancers Likely to Express NaPi2b

Mersana Therapeutics

NCT06517485

COMPLETED Phase 1 62 participants

First-in-Human Dose Escalation Study of XMT-1536 in Cancers Likely to Express NaPi2b

Mersana Therapeutics

NCT06517433

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 4
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Platinum-resistant Ovarian Cancer Trial Landscape

18 indexed Platinum-resistant Ovarian Cancer studies · 11 recruiting (61%).

Phase mix: 3 late (III/IV) vs 15 early (I/II).

Top sponsor: Mersana Therapeutics (3 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Platinum-resistant Ovarian Cancer?

PlainTrial tracks 18 US clinical trials for Platinum-resistant Ovarian Cancer, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Platinum-resistant Ovarian Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.