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ACTIVE NOT RECRUITING Phase 3

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236 · View on ClinicalTrials.gov ↗

Study Summary

This phase 3 study will be conducted in different countries all over the world. The purpose of this study is to compare how well Rina-S works against platinum-resistant ovarian cancer compared to chemotherapy drugs that are already approved and used for platinum-resistant ovarian cancer. Treatment in this study could be Rina-S or it could be 1 of 4 indicated chemotherapy agents that are considered standard medical care. There is an equal (50:50) chance of getting Rina-S or an approved chemotherapy agent as treatment in this study. No one will know what treatment they are assigned to until the first dose. All participants will receive active drug; no one will be given placebo.

Interventions

  • DRUG Paclitaxel
  • DRUG Gemcitabine
  • DRUG Topotecan
  • DRUG Rina-S
  • DRUG Pegylated liposomal doxorubicin (PLD)

Study Locations (20)

Florida

  • SCRI - Florida Cancer Specialists - South Region Research Office — Fort Myers
  • Mount Sinai Comprehensive Cancer Center — Miami Beach
  • Orlando Health Cancer Institute - Downtown Orlando — Orlando
  • Sarasota Memorial Hospital — Sarasota
  • SCRI - Florida Cancer Specialists - West Palm Beach — West Palm Beach

California

  • Providence Saint Joseph Medical Center - Roy and Patricia Disney Family Cancer Center — Burbank
  • University of California San Diego Moores Cancer Center — La Jolla
  • USCF Mission Bay — San Francisco
  • Kaiser Permanente - Vallejo Medical Center — Vallejo

Connecticut

  • Hartford Hospital — Hartford
  • Yale School of Medicine — New Haven
  • Norwalk Hospital — Norwalk

Georgia

  • Winship Cancer Institute of Emory University — Atlanta
  • Northside Hospital Atlanta — Atlanta
  • Augusta University Georgia Cancer Center — Augusta

Arizona

  • Arizona Center for Cancer Care (ACCC) - Biltmore — Scottsdale
  • University of Arizona Cancer Center - Research and Administration at Main Campus — Tucson

Alaska

  • Alaska Women's Cancer Care — Anchorage

Colorado

  • UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center — Aurora

Hawaii

  • Kapi'olani Medical Center for Women and Children — Honolulu

Trial Details

FieldValue
Enrollment Target 530 participants
Start Date 2025-02-07
Est. Completion 2028-05-23
Phase Phase 3

Sponsor

Genmab

59 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06619236

The ClinicalTrials.gov registry entry for NCT06619236 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 530 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genmab, which has 59 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Platinum-resistant Ovarian Cancer appearing as the primary indexed condition, and to 5 interventions — of which Paclitaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06619236 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Florida, California, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06619236 about?

NCT06619236 is a clinical study titled "Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer". This phase 3 study will be conducted in different countries all over the world. The purpose of this study is to compare how well Rina-S works against platinum-resistant ovarian cancer compared to chemotherapy drugs that are already approved and used for platinum-resistant ovarian cancer. Treatment...

What is the current status of trial NCT06619236?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 530 participants. The study started on 2025-02-07. Estimated completion is 2028-05-23.

What conditions does trial NCT06619236 study?

This clinical trial studies the following conditions: Platinum-resistant Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06619236?

The interventions under investigation include: Paclitaxel (DRUG), Gemcitabine (DRUG), Topotecan (DRUG), Rina-S (DRUG), Pegylated liposomal doxorubicin (PLD) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06619236?

This trial is sponsored by Genmab, which has 59 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06619236 being conducted?

This trial has 20 study locations across Alaska, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial