Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06517485 · ClinicalTrials.gov registry record · Phase 1
First-in-Human Dose Expansion Study of XMT-1536 in Cancers Likely to Express NaPi2b
A Phase 1 study of Platinum-resistant Ovarian Cancer and Non-Small Cell Adenocarcinoma, sponsored by Mersana Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 142
- Enrollment target
- 1
- Study location
NCT06517485: Completed Phase 1 study of Platinum-resistant Ovarian Cancer and Non-Small Cell Adenocarcinoma, sponsored by Mersana Therapeutics.
NCT06517485 is a Phase 1 study of Platinum-resistant Ovarian Cancer and Non-Small Cell Adenocarcinoma that has completed, run by Mersana Therapeutics. The registered enrollment target is 142 participants, below the 178-participant average among 17 other Platinum-resistant Ovarian Cancer trials with a reported enrollment target (20% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06517485, a Phase 1 study of Platinum-resistant Ovarian Cancer and Non-Small Cell Adenocarcinoma, has completed, sponsored by Mersana Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 142 participants
- Enrollment target
- 1
- Study location
Study Summary
First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the expansion segment of this study. In addition to safety assessments, the pharmacokinetics of the drug were assessed along with ADC activity.
Primary Outcome
Evaluate incidence and severity of adverse events
Conditions Studied
Interventions
- DRUG upifitamab rilsodotin
Study Locations (1)
Oklahoma
- University of Oklahoma - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 142 participants |
| Start Date | 2019-07-30 |
| Est. Completion | 2022-08-03 |
| Phase | Phase 1 |
What the finished NCT06517485 record still lists
NCT06517485 is an interventional study that assigns participants to a tested intervention. The registered 142 participants enrollment target is mid-sized for trials with a published cap, below the 178-participant average among 17 other Platinum-resistant Ovarian Cancer trials with a reported enrollment target (20% lower).
The record links to 2 conditions, with Platinum-resistant Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention - of which upifitamab rilsodotin is the first listed.
NCT06517485 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT06517485 about?
NCT06517485 is a clinical study titled "First-in-Human Dose Expansion Study of XMT-1536 in Cancers Likely to Express NaPi2b". First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the ex...
What is the current status of trial NCT06517485?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 142 participants. The study started on 2019-07-30. Estimated completion is 2022-08-03.
What conditions does trial NCT06517485 study?
This clinical trial studies the following conditions: Platinum-resistant Ovarian Cancer, Non-Small Cell Adenocarcinoma.
What interventions are being tested in trial NCT06517485?
The interventions under investigation include: upifitamab rilsodotin (DRUG).
Who is sponsoring clinical trial NCT06517485?
This trial is sponsored by Mersana Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06517485 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Platinum-resistant Ovarian Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06517485's enrollment target sits among peer trials
142 9th of 17 higher than 9 of 17 other Platinum-resistant Ovarian Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Platinum-resistant Ovarian Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.
RECRUITING · Phase 1
-
A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer
RECRUITING · Phase 1
-
Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer
RECRUITING · Phase 1
-
A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors
RECRUITING · Phase 1
-
A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.
RECRUITING · Phase 1
-
Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03933631 · 142 participants · Phase 3
Pilocarpine Use After Kahook Goniotomy
- NCT04938349 · 142 participants · NA
Dual Task Perturbation Training for OAwMCI
- NCT06117254 · 142 participants · NA
Hearing Aids for Veterans With Functional Hearing Difficulties
- NCT06463665 · 142 participants · Phase 2
Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI