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NCT06517433 · ClinicalTrials.gov registry record · Phase 1
First-in-Human Dose Escalation Study of XMT-1536 in Cancers Likely to Express NaPi2b
A Phase 1 study of Platinum-resistant Ovarian Cancer and Non Small Cell Lung Cancer Metastatic, sponsored by Mersana Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 62
- Enrollment target
- 1
- Study location
NCT06517433: Completed Phase 1 study of Platinum-resistant Ovarian Cancer and Non Small Cell Lung Cancer Metastatic, sponsored by Mersana Therapeutics.
NCT06517433 is a Phase 1 study of Platinum-resistant Ovarian Cancer and Non Small Cell Lung Cancer Metastatic that has completed, run by Mersana Therapeutics. The registered enrollment target is 62 participants, below the 182-participant average among 17 other Platinum-resistant Ovarian Cancer trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06517433, a Phase 1 study of Platinum-resistant Ovarian Cancer and Non Small Cell Lung Cancer Metastatic, has completed, sponsored by Mersana Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 62 participants
- Enrollment target
- 1
- Study location
Study Summary
First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with tumor types likely to express NaPi2b were enrolled in dose escalation. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the expansion segment of this study. In addition to safety assessments, the pharmacokinetics of the drug were assessed along with ADC activity.
Primary Outcome
Evaluate adverse events and concomitant medication use after XMT-1536 (upifitamab rilsodotin) doses
Conditions Studied
Interventions
- DRUG upifitamab rilsodotin
Study Locations (1)
Oklahoma
- University of Oklahoma - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2017-12-12 |
| Est. Completion | 2021-07-09 |
| Phase | Phase 1 |
What the finished NCT06517433 record still lists
NCT06517433 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 182-participant average among 17 other Platinum-resistant Ovarian Cancer trials with a reported enrollment target (66% lower).
The record links to 2 conditions, with Platinum-resistant Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention - of which upifitamab rilsodotin is the first listed.
NCT06517433 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT06517433 about?
NCT06517433 is a clinical study titled "First-in-Human Dose Escalation Study of XMT-1536 in Cancers Likely to Express NaPi2b". First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with tumor types likely to express NaPi2b were enrolled in dose escalation. Patients with platinum-resistant ovarian c...
What is the current status of trial NCT06517433?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2017-12-12. Estimated completion is 2021-07-09.
What conditions does trial NCT06517433 study?
This clinical trial studies the following conditions: Platinum-resistant Ovarian Cancer, Non Small Cell Lung Cancer Metastatic.
What interventions are being tested in trial NCT06517433?
The interventions under investigation include: upifitamab rilsodotin (DRUG).
Who is sponsoring clinical trial NCT06517433?
This trial is sponsored by Mersana Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06517433 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06517433's enrollment target sits among peer trials
62 12th of 17 higher than 6 of 17 other Platinum-resistant Ovarian Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Platinum-resistant Ovarian Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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