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ClinicalTrials.gov 35 recruiting now official registry

Peripheral Arterial Disease clinical trials

35 of 80 indexed Peripheral Arterial Disease trials are currently recruiting.

80 US clinical trials · 35 currently recruiting

Peripheral Arterial Disease is the subject of 80 registered US clinical trials on ClinicalTrials.gov, 35 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Nebraska, running 7 of these trials.

The research picture

Peripheral Arterial Disease has 80 registered US clinical trials, 35 of them open to new participants right now, about 44% of the total.

35
recruiting participants now
44%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
7
top sponsor: University of Nebraska
Phase 19Phase 25Phase 33Phase 44

Active & Recent Trials

80 total, page 2 of 2

COMPLETED NA 174 participants

Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD)

University of Kansas Medical Center

NCT01321086

COMPLETED 161 participants

Validation of a Novel Oscillometric-Based Algorithm for Determination of the Ankle-Brachial Index

Summit Doppler Systems

NCT01165437

COMPLETED NA 130 participants

A Prospective Single-Arm Multicenter StuDy of the BarE TEmporary SPur StEnt System foR the tREatment of Vascular Lesions Located in the infrapoplitEal Arteries beLow the Knee (DEEPER REVEAL)

ReFlow Medical

NCT05358353

COMPLETED NA 116 participants

Implementation of Telemedicine for Patient With Lower Extremity Wounds

University of California, Davis

NCT04440839

COMPLETED NA 112 participants

The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee

Horizons International Peripheral Group

NCT02464501

COMPLETED NA 108 participants

EverFlex Post Approval Study

Medtronic Endovascular

NCT01680835

COMPLETED NA 108 participants

A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages

Ra Medical Systems

NCT04241224

COMPLETED 100 participants

Distributed Registry

Stanford University

NCT03898570

COMPLETED Phase 2 86 participants

Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia

Vericel Corporation

NCT00468000

COMPLETED 82 participants

TurboPower + DCB Treatment of Femoropopliteal De Novo/ Restenotic and In-Stent Restenosis Lesions

Spectranetics Corporation

NCT03306199

COMPLETED Phase 1 81 participants

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Indiana University

NCT02685098

COMPLETED 70 participants

Pilot Study to Determine the Optimal Technique for Measurement of Ankle Blood Pressures

Summit Doppler Systems

NCT00819598

COMPLETED Phase 4 55 participants

The Jetstream G3™ Calcium Study

Boston Scientific Corporation

NCT01273623

COMPLETED 40 participants

VasoStat vs. TR Band for Radial Hemostasis

Forge Medical

NCT04163471

COMPLETED Phase 2 32 participants

Nitrites, Exercise, and Peripheral Arterial Disease

Duke University

NCT01684930

COMPLETED NA 27 participants

Local Paclitaxel Delivery for SFA Disease

University of Oklahoma

NCT00821028

COMPLETED NA 24 participants

Ischemic Preconditioning Claudication Study

Medical College of Wisconsin

NCT03511157

COMPLETED NA 22 participants

Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization

University of California, San Francisco

NCT01507558

COMPLETED NA 22 participants

Cardiac Rehabilitation Program in Peripheral Arterial Disease

University of Kansas Medical Center

NCT03251391

COMPLETED Phase 1 20 participants

ALD-301 for Critical Limb Ischemia, Randomized Trial

Aldagen

NCT00392509

COMPLETED NA 19 participants

Endothelial Function in Lower Extremity Bypass Grafts

Brigham and Women's Hospital

NCT00759707

COMPLETED NA 18 participants

Exercise and Weight Loss in PAD

VA Office of Research and Development

NCT02607033

COMPLETED Phase 1 15 participants

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Celularity Incorporated

NCT01859117

COMPLETED NA 15 participants

Drug Eluting Stent for the Management of PERipheral Arterial Disease Of the SFA (DESPERADO-SFA Study)

Arkansas Heart Hospital

NCT02734836

COMPLETED NA 12 participants

Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)

Vibrato Medical

NCT05888740

COMPLETED NA 11 participants

Dietary Nitrate Supplementation and Thermoregulation

University of Nebraska

NCT03506646

COMPLETED Early Phase 1 10 participants

Safety and Preliminary Efficacy of Adipose Derived Stem Cells and Low Frequency Ultrasound in PAD

Arkansas Heart Hospital

NCT02756884

COMPLETED Phase 1 9 participants

Natural Vascular Scaffold (NVS) Therapy for Treatment of Atherosclerotic Lesions (Activate I)

Alucent Biomedical

NCT04188262

COMPLETED NA 8 participants

The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention

University of California, San Francisco

NCT02096757

COMPLETED NA 5 participants

BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI

Zimmer Biomet

NCT02601430

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 5
Phase 3 3
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Peripheral Arterial Disease Trial Landscape

80 indexed Peripheral Arterial Disease studies · 35 recruiting (44%).

Phase mix: 7 late (III/IV) vs 14 early (I/II).

Top sponsor: University of Nebraska (7 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Peripheral Arterial Disease?

PlainTrial tracks 80 US clinical trials for Peripheral Arterial Disease, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Peripheral Arterial Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.