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ClinicalTrials.gov 6 recruiting now official registry

Non-Small-Cell Lung Carcinoma clinical trials

6 of 32 indexed Non-Small-Cell Lung Carcinoma trials are currently recruiting.

32 US clinical trials · 6 currently recruiting

Non-Small-Cell Lung Carcinoma is the subject of 32 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Pfizer, running 3 of these trials.

The research picture

Non-Small-Cell Lung Carcinoma has 32 registered US clinical trials, 6 of them open to new participants right now, about 19% of the total.

6
recruiting participants now
19%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: Pfizer
Phase 113Phase 210Phase 35

Active & Recent Trials

32 total, page 1 of 1

RECRUITING 800 participants

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

VastBiome

NCT05037825

RECRUITING Phase 3 680 participants

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

Pfizer

NCT07144280

RECRUITING Phase 1 252 participants

Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations

AbbVie

NCT06772623

RECRUITING Phase 1 210 participants

A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC

AstraZeneca

NCT04995523

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 40 participants

Retifanlimab and Ruxolitinib In Solid Malignancies

University of California, San Diego

NCT07219576

ACTIVE NOT RECRUITING Phase 1 115 participants

DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer

Daiichi Sankyo

NCT04042701

ACTIVE NOT RECRUITING Phase 2 83 participants

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

NeoImmuneTech

NCT04984811

ACTIVE NOT RECRUITING Phase 1 74 participants

Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Novartis Pharmaceuticals

NCT05358249

ACTIVE NOT RECRUITING NA 70 participants

Online Psychosocial Intervention in Improving Social Well-Being and Support in Women With Stage I-IV Non-small Cell Lung Cancer Undergoing Treatment

M.D. Anderson Cancer Center

NCT03731585

ACTIVE NOT RECRUITING Phase 2 43 participants

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Joseph J. Cullen, MD, FACS

NCT02905591

ACTIVE NOT RECRUITING Phase 1 11 participants

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

City of Hope Medical Center

NCT02432963

ACTIVE NOT RECRUITING Phase 1 9 participants

Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery

Roswell Park Cancer Institute

NCT03678350

COMPLETED Phase 3 1,264 participants

Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)

Merck Sharp & Dohme

NCT04738487

COMPLETED Phase 3 1,052 participants

Albumin-bound Paclitaxel (ABI-007) for Patients With Advanced Non-Small Cell Lung Cancer

Celgene

NCT00540514

COMPLETED Phase 3 520 participants

Study of TLK286 (Telcyta) vs. Gefitinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Telik

NCT00080340

COMPLETED Phase 2 275 participants

Trial of Image-Guided Adaptive Conformal Photon vs Proton Therapy, With Concurrent Chemotherapy, for Locally Advanced Non-Small Cell Lung Carcinoma: Treatment Related Pneumonitis and Locoregional Recurrence

M.D. Anderson Cancer Center

NCT00915005

COMPLETED Phase 3 228 participants

Alimta® Versus Its Combination With Carboplatin in Advanced Non-small-cell Lung Cancer in Patients Performance Status 2

Instituto Nacional de Cancer, Brazil

NCT01836575

COMPLETED 161 participants

Anaplastic Lymphoma Kinase (ALK)-Positive Non-small Cell Lung Cancer (NSCLC) Post-alectinib Treatment Patterns

Pfizer

NCT04351334

COMPLETED Phase 1 150 participants

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Xencor

NCT03517488

COMPLETED Phase 1 141 participants

Study to Evaluate Erlotinib With or Without SNDX-275 (Entinostat) in the Treatment of Patients With Advanced NSCLC

Syndax Pharmaceuticals

NCT00602030

COMPLETED Phase 1 138 participants

A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib Treatment

Hoffmann-La Roche

NCT01801111

COMPLETED Phase 2 130 participants

Subcutaneous Amifostine (Ethyol®) in the Prevention of Radiochemotherapy-Induced Esophagitis and Pneumonitis in Patients With Unresectable Non-Small Cell Lung Cancer

MedImmune

NCT00081315

COMPLETED Phase 2 118 participants

A Study Of AG-013736 (Axitinib) Or Bevacizumab (Avastin) In Combination With Paclitaxel And Carboplatin In Patients With Advanced Lung Cancer.

Pfizer

NCT00600821

COMPLETED Phase 2 85 participants

Study Investigating the Effect of Everolimus Monotherapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)

Novartis Pharmaceuticals

NCT00124280

COMPLETED Phase 2 82 participants

Study of OSI-774 (Tarceva) in Previously Untreated Elderly Lung Cancer Patients

Dana-Farber Cancer Institute

NCT00137800

COMPLETED Phase 2 50 participants

Enzastaurin as Second and Third-Line Treatment for Non-Small Cell Lung Cancer.

Eli Lilly and Company

NCT00105092

COMPLETED Phase 1 36 participants

A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC)

Pharmacyclics

NCT00102505

COMPLETED Phase 1 35 participants

Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

Rahul Aggarwal

NCT03590054

COMPLETED Phase 2 35 participants

Neoadjuvant Pembrolizumab

Neal Ready MD PhD

NCT02818920

COMPLETED NA 29 participants

Stereotactic Body Radiation Therapy (SBRT) in Metastatic Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT01185639

COMPLETED Phase 2

Study of ILX651 in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Carcinoma

Genzyme, a Sanofi Company

NCT00078455

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 10
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small-Cell Lung Carcinoma Trial Landscape

32 indexed Non-Small-Cell Lung Carcinoma studies · 6 recruiting (19%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: Pfizer (3 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small-Cell Lung Carcinoma?

PlainTrial tracks 32 US clinical trials for Non-Small-Cell Lung Carcinoma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small-Cell Lung Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.