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NCT04995523 · ClinicalTrials.gov registry record · Phase 1
A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
A Phase 1 study of Non-Small-Cell Lung Carcinoma, sponsored by AstraZeneca.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 210
- Enrollment target
- 20
- Study locations
NCT04995523: Recruiting Phase 1 study of Non-Small-Cell Lung Carcinoma, sponsored by AstraZeneca.
NCT04995523 is a Phase 1 study of Non-Small-Cell Lung Carcinoma that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 210 participants, roughly in line with the 229-participant average among 30 other Non-Small-Cell Lung Carcinoma trials with a reported enrollment target. The trial reports 20 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04995523, a Phase 1 study of Non-Small-Cell Lung Carcinoma, is actively recruiting participants, sponsored by AstraZeneca.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 210 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.
Primary Outcome
A DLT is a toxicity defined by the study protocol that occurs from the first dose of study intervention up to the end of the DLT evaluation period that is assessed as clearly unrelated to the primary disease or intercurrent illness.
Conditions Studied
Interventions
- DRUG AZD2936
Study Locations (20)
Other
- Research Site - Melbourne
- Research Site - Anderlecht
- Research Site - Leuven
- Research Site - Florianópolis
- Research Site - Natal
- Research Site - Porto Alegre
- Research Site - Rio de Janeiro
- Research Site - São Paulo
- Research Site - Chengdu
- Research Site - Chongqing
- Research Site - Wuhan
- Research Site - Copenhagen
- Research Site - Dijon
- Research Site - Toulouse
California
- Research Site - Orange
Illinois
- Research Site - Chicago
Maryland
- Research Site - Baltimore
Minnesota
- Research Site - Rochester
Texas
- Research Site - Houston
Virginia
- Research Site - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 210 participants |
| Start Date | 2021-09-14 |
| Est. Completion | 2028-03-16 |
| Phase | Phase 1 |
What NCT04995523 shows while recruiting
NCT04995523 is an interventional study that assigns participants to a tested intervention. The registered 210 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 229-participant average among 30 other Non-Small-Cell Lung Carcinoma trials with a reported enrollment target.
The record links to 1 condition, with Non-Small-Cell Lung Carcinoma appearing as the primary indexed condition, and to 1 intervention - of which AZD2936 is the first listed.
NCT04995523 names 20 study sites across 7 states, led by Other, California, Illinois.
Frequently Asked Questions
What is clinical trial NCT04995523 about?
NCT04995523 is a clinical study titled "A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC". This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.
What is the current status of trial NCT04995523?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 210 participants. The study started on 2021-09-14. Estimated completion is 2028-03-16.
What conditions does trial NCT04995523 study?
This clinical trial studies the following conditions: Non-Small-Cell Lung Carcinoma.
What interventions are being tested in trial NCT04995523?
The interventions under investigation include: AZD2936 (DRUG).
Who is sponsoring clinical trial NCT04995523?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04995523 being conducted?
This trial has 20 study locations across California, Illinois, Maryland, Minnesota, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04995523's enrollment target sits among peer trials
210 9th of 30 higher than 22 of 30 other Non-Small-Cell Lung Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small-Cell Lung Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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