Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC

NCT04995523 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.

Interventions

  • DRUG AZD2936

Study Locations (20)

Other

  • Research Site — Melbourne
  • Research Site — Anderlecht
  • Research Site — Leuven
  • Research Site — Florianópolis
  • Research Site — Natal
  • Research Site — Porto Alegre
  • Research Site — Rio de Janeiro
  • Research Site — São Paulo
  • Research Site — Chengdu
  • Research Site — Chongqing
  • Research Site — Wuhan
  • Research Site — Copenhagen
  • Research Site — Dijon
  • Research Site — Toulouse

California

  • Research Site — Orange

Illinois

  • Research Site — Chicago

Maryland

  • Research Site — Baltimore

Minnesota

  • Research Site — Rochester

Texas

  • Research Site — Houston

Virginia

  • Research Site — Fairfax

Trial Details

FieldValue
Enrollment Target 210 participants
Start Date 2021-09-14
Est. Completion 2028-03-16
Phase Phase 1

Sponsor

AstraZeneca

1,053 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04995523

The ClinicalTrials.gov registry entry for NCT04995523 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 210 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-Small-Cell Lung Carcinoma appearing as the primary indexed condition, and to 1 intervention — of which AZD2936 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04995523 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04995523 about?

NCT04995523 is a clinical study titled "A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC". This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.

What is the current status of trial NCT04995523?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 210 participants. The study started on 2021-09-14. Estimated completion is 2028-03-16.

What conditions does trial NCT04995523 study?

This clinical trial studies the following conditions: Non-Small-Cell Lung Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04995523?

The interventions under investigation include: AZD2936 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04995523?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04995523 being conducted?

This trial has 20 study locations across California, Illinois, Maryland, Minnesota, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial