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ClinicalTrials.gov 8 recruiting now early-phase tilt

Muscle Weakness: early-phase trial registry

8 of 26 indexed Muscle Weakness trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #627 of 28,707 conditions by registered trial count.

26 US clinical trials · 8 currently recruiting · #627 of 28,707 conditions by registered trial count

Muscle Weakness: 26 US clinical trials tracked, 8 recruiting.

Muscle Weakness is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is The University of Texas Medical Branch, Galveston, running 2 of these trials.

Enrollment posture brief

Registry condition muscle-weakness

OPEN 8 | RECR 31% | LATE 3 | EARLY 5 | RANK #627 | SPON 2

Nearest open-share peer: Accidental Falls (31% recruiting · 13 trials)

Autoimmune Diseases53.8%Muscle Weakness (this)31%Cancer Survivor26.9%Anaplastic Large Cell Lympho19.2%Adult Acute Myeloid Leukemia0%
Open-enrollment share among volume-matched conditions near Muscle Weakness

Muscle Weakness lists 8 open slots (31% of 26 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Muscle Weakness on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Muscle Weakness is recruiting below its size-band peers.

    8 of 26 indexed trials (30.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Muscle Weakness trials is spread across many organizations.

    The University of Texas Medical Branch, Galveston accounts for 2 of 26 trials (7.7%). 24 distinct sponsors appear on at least one study for this condition label.

  3. Most Muscle Weakness trials plan to enrol fewer than 100 people.

    Median target enrolment is 60 among the 26 trials that report a genuine target (sentinel values excluded). 22 of those (84.6%) plan for fewer than 100 participants.

  4. Muscle Weakness research is mostly interventional.

    22 interventional and 4 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 22Phase 43

Open and recent trials

26 total, page 1 of 1

RECRUITING 209 participants

Muscle Recovery After Critical Illness

Kirby Mayer

NCT05537298

RECRUITING Phase 4 80 participants

Depo-Medrol on Psoas After LLIF

Hardeep Singh

NCT05929755

RECRUITING NA 70 participants

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

University of Colorado, Denver

NCT06129110

RECRUITING NA 60 participants

THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation

The University of Texas Medical Branch, Galveston

NCT06395506

RECRUITING NA 60 participants

Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors

St. Jude Children's Research Hospital

NCT06819475

RECRUITING Phase 1 30 participants

A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

Arcellx

NCT06626919

RECRUITING 23 participants

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

National Institutes of Health Clinical Center (CC)

NCT06998134

RECRUITING NA 16 participants

FIT Exercise in 30d of ULLS-induced Muscle Disuse

Lance Bollinger

NCT06631053

ACTIVE NOT RECRUITING 312 participants

Measuring Outcomes of Activity in Intensive Care

Vanderbilt University Medical Center

NCT03115840

ACTIVE NOT RECRUITING NA 90 participants

Inspiratory Muscle Training Immediately After Lung Transplantation

Ohio State University

NCT05309551

ACTIVE NOT RECRUITING NA 74 participants

Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.

Impactiv

NCT06458530

ACTIVE NOT RECRUITING NA 60 participants

Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes

University of Maryland, Baltimore

NCT02509520

ACTIVE NOT RECRUITING NA 33 participants

HIFEM and Radiofrequency for Muscular System Function Improvement

BTL Industries

NCT06703749

ACTIVE NOT RECRUITING NA 25 participants

Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome

Bijan Najafi, PhD

NCT06238609

COMPLETED Phase 4 201 participants

Best Practice Using Rocuronium and Reversal With Neostigmine or Sugammadex

University of Washington

NCT03543826

COMPLETED Phase 2 108 participants

HORMA: Hormonal Regulators of Muscle and Metabolism in Aging

National Institute on Aging (NIA)

NCT00183040

COMPLETED Phase 4 88 participants

Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly

US Department of Veterans Affairs

NCT00018356

COMPLETED 80 participants

Use of Jumping Mechanography as a Method to Assess Musculoskeletal Status in Older Adults

University of Wisconsin, Madison

NCT00596089

COMPLETED NA 77 participants

Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients

The University of Texas Medical Branch, Galveston

NCT02739464

COMPLETED NA 57 participants

Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation

RML Specialty Hospital

NCT01825135

COMPLETED NA 32 participants

Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19

University of Kentucky

NCT04412330

COMPLETED NA 31 participants

Combined Effects of Nutritional and Exercise Countermeasures

University of Arkansas

NCT00447044

COMPLETED Phase 1 19 participants

Electrical Stimulation for Critically Ill Covid-19 Patients

Baylor College of Medicine

NCT04685213

COMPLETED Phase 1 16 participants

Energetics and Function in Older Humans

Baylor College of Medicine

NCT02348762

COMPLETED Phase 2 15 participants

Testosterone Therapy After Hip Fracture in Elderly Women

Washington University School of Medicine

NCT00280267

COMPLETED NA 8 participants

7 Tesla MRI Study in Patients With Statin Related Muscle Complaints

University of Texas Southwestern Medical Center

NCT04575090

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 4 3

Named interventions

Most-linked intervention names on Muscle Weakness records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Electrical Stimulation - Sham Device
1 trials
Neuromuscular electrical stimulation Device
1 trials
essential amino acids Dietary supplement
1 trials
diet orange soda Dietary supplement
1 trials
exercise Procedure
1 trials
testosterone Drug
1 trials
SOC Pt/ot Other
1 trials
Exercise + SOC PT/OT Other
1 trials

US sites by state

Facility locations filed on Muscle Weakness trials. A trial with sites in several states counts in each.

Texas 7 trials
Ohio 3 trials
Kentucky 3 trials
Tennessee 2 trials
Missouri 2 trials
Maryland 2 trials
Florida 2 trials
Colorado 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Muscle Weakness page

26 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Muscle Weakness condition card totals 26 registered trials; most-linked intervention Electrical Stimulation - Sham; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.