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ClinicalTrials.gov 4 recruiting now official registry

Mitral Valve Insufficiency clinical trials

4 of 12 indexed Mitral Valve Insufficiency trials are currently recruiting.

12 US clinical trials · 4 currently recruiting

Mitral Valve Insufficiency is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Edwards Lifesciences, running 4 of these trials.

The research picture

Mitral Valve Insufficiency has 12 registered US clinical trials, 4 of them open to new participants right now, about 33% of the total.

4
recruiting participants now
33%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Edwards Lifesciences
Phase 21

Active & Recent Trials

12 total, page 1 of 1

RECRUITING NA 900 participants

The ENCIRCLE Trial

Edwards Lifesciences

NCT04153292

RECRUITING NA 585 participants

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

NeoChord

NCT02803957

RECRUITING NA 300 participants

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Cardiac Dimensions

NCT03142152

RECRUITING NA 30 participants

The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study

Half Moon Medical

NCT04343313

ACTIVE NOT RECRUITING NA 777 participants

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

Edwards Lifesciences

NCT01757665

ACTIVE NOT RECRUITING 504 participants

Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Edwards Lifesciences

NCT05526560

ACTIVE NOT RECRUITING 368 participants

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Icahn School of Medicine at Mount Sinai

NCT03066050

ACTIVE NOT RECRUITING NA 128 participants

Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System

Medtronic Cardiovascular

NCT02322840

ACTIVE NOT RECRUITING NA 103 participants

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Abbott Medical Devices

NCT03433274

ACTIVE NOT RECRUITING NA 53 participants

PARTNER 3 Trial - Mitral Valve in Valve

Edwards Lifesciences

NCT03193801

COMPLETED Phase 2 300 participants

Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery

Avant Immunotherapeutics

NCT00082121

COMPLETED 200 participants

Investigation of Heart Function in Patients With Heart Valve Defects

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001314

Phase Distribution

PhaseTrial count
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mitral Valve Insufficiency Trial Landscape

12 indexed Mitral Valve Insufficiency studies · 4 recruiting (33%).

Phase mix: 0 late (III/IV) vs 1 early (I/II).

Top sponsor: Edwards Lifesciences (4 trials), 8 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mitral Valve Insufficiency?

PlainTrial tracks 12 US clinical trials for Mitral Valve Insufficiency, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mitral Valve Insufficiency?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.