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Mitral Valve Insufficiency clinical trials
4 of 12 indexed Mitral Valve Insufficiency trials are currently recruiting.
12 US clinical trials · 4 currently recruiting
Mitral Valve Insufficiency is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Edwards Lifesciences, running 4 of these trials.
The research picture
Mitral Valve Insufficiency has 12 registered US clinical trials, 4 of them open to new participants right now, about 33% of the total.
- 4
- recruiting participants now
- 33%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Edwards Lifesciences
Active & Recent Trials
12 total, page 1 of 1
The ENCIRCLE Trial
Edwards Lifesciences
NCT04153292
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NeoChord
NCT02803957
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
Half Moon Medical
NCT04343313
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
Edwards Lifesciences
NCT05526560
Long Term Follow Up for CTSN Mitral Valve Repair Studies
Icahn School of Medicine at Mount Sinai
NCT03066050
Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System
Medtronic Cardiovascular
NCT02322840
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
Abbott Medical Devices
NCT03433274
PARTNER 3 Trial - Mitral Valve in Valve
Edwards Lifesciences
NCT03193801
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
Avant Immunotherapeutics
NCT00082121
Investigation of Heart Function in Patients With Heart Valve Defects
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001314
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mitral Valve Insufficiency Trial Landscape
12 indexed Mitral Valve Insufficiency studies · 4 recruiting (33%).
Phase mix: 0 late (III/IV) vs 1 early (I/II).
Top sponsor: Edwards Lifesciences (4 trials), 8 others listed. 12 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mitral Valve Insufficiency?
PlainTrial tracks 12 US clinical trials for Mitral Valve Insufficiency, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mitral Valve Insufficiency?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.