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Mitral Valve Insufficiency: early-phase trial registry
4 of 12 indexed Mitral Valve Insufficiency trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,429 of 28,707 conditions by registered trial count.
12 US clinical trials · 4 currently recruiting · #1,429 of 28,707 conditions by registered trial count
Mitral Valve Insufficiency: 12 US clinical trials tracked, 4 recruiting.
Mitral Valve Insufficiency is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Edwards Lifesciences, running 4 of these trials.
Enrollment posture brief
Registry condition mitral-valve-insufficiency
OPEN 4 | RECR 33% | LATE 0 | EARLY 1 | RANK #1429 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)
Mitral Valve Insufficiency lists 4 open slots (33% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mitral Valve Insufficiency on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mitral Valve Insufficiency is recruiting below its size-band peers.
4 of 12 indexed trials (33.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Mitral Valve Insufficiency research.
Edwards Lifesciences accounts for 4 of 12 trials (33.3%). 9 distinct sponsors appear on at least one study for this condition label.
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Typical Mitral Valve Insufficiency enrolment sits around 300 participants.
Median target enrolment is 300 among the 12 trials that report a genuine target (sentinel values excluded). 2 of those (16.7%) plan for fewer than 100 participants.
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Mitral Valve Insufficiency research is mostly interventional.
9 interventional and 3 observational studies make up this index (75% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
12 total, page 1 of 1
The ENCIRCLE Trial
Edwards Lifesciences
NCT04153292
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NeoChord
NCT02803957
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
Half Moon Medical
NCT04343313
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
Edwards Lifesciences
NCT05526560
Long Term Follow Up for CTSN Mitral Valve Repair Studies
Icahn School of Medicine at Mount Sinai
NCT03066050
Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System
Medtronic Cardiovascular
NCT02322840
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
Abbott Medical Devices
NCT03433274
PARTNER 3 Trial - Mitral Valve in Valve
Edwards Lifesciences
NCT03193801
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
Avant Immunotherapeutics
NCT00082121
Investigation of Heart Function in Patients With Heart Valve Defects
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001314
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Mitral Valve Insufficiency records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mitral Valve Insufficiency trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mitral Valve Insufficiency page
12 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Mitral Valve Insufficiency trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Edwards Lifesciences sponsors the most Mitral Valve Insufficiency trials on record, review their full trial history before evaluating a specific study. See Edwards Lifesciences's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mitral Valve Insufficiency condition card totals 12 registered trials; most-linked intervention TP10; top US site state Georgia. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.