Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 6 recruiting now official registry

Metabolic Diseases clinical trials

6 of 13 indexed Metabolic Diseases trials are currently recruiting.

13 US clinical trials · 6 currently recruiting

Metabolic Diseases is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 2 of these trials.

The research picture

Metabolic Diseases has 13 registered US clinical trials, 6 of them open to new participants right now, about 46% of the total.

6
recruiting participants now
46%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Massachusetts General Hospital
Phase 12Phase 22Phase 31Phase 41

Active & Recent Trials

13 total, page 1 of 1

RECRUITING 1,550 participants

Genetic and Metabolic Disease in Children

University of Texas Southwestern Medical Center

NCT02650622

RECRUITING NA 177 participants

Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs

C5 Biomedical

NCT06674980

RECRUITING Phase 4 125 participants

GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

Massachusetts General Hospital

NCT06003153

RECRUITING NA 74 participants

The Effect of Processing on Food Reward

Virginia Polytechnic Institute and State University

NCT06017986

RECRUITING NA 40 participants

Effects of HIIT vs. TRE on Type 2 Diabetes Risk

Syracuse University

NCT07215533

RECRUITING NA 20 participants

Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc

University of California, Davis

NCT05236374

ACTIVE NOT RECRUITING 46 participants

Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans

University of Pittsburgh

NCT02710370

ACTIVE NOT RECRUITING 36 participants

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)

AdventHealth Translational Research Institute

NCT01745471

COMPLETED Phase 3 144 participants

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Kastle Therapeutics

NCT00694109

COMPLETED Phase 1 84 participants

Single-Dose And Multiple-Dose Safety And Tolerability Study Of PF-04856883 In Type 2 Diabetic Adult Females

Pfizer

NCT01301456

COMPLETED Phase 2 50 participants

Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00119379

COMPLETED Phase 1 16 participants

Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test

Massachusetts General Hospital

NCT04958109

COMPLETED Phase 2 16 participants

Pilot Study To Assess CAT-2003 in Patients With Severe Hypertriglyceridemia

Catabasis Pharmaceuticals

NCT01968720

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metabolic Diseases Trial Landscape

13 indexed Metabolic Diseases studies · 6 recruiting (46%).

Phase mix: 2 late (III/IV) vs 4 early (I/II).

Top sponsor: Massachusetts General Hospital (2 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metabolic Diseases?

PlainTrial tracks 13 US clinical trials for Metabolic Diseases, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metabolic Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.