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ClinicalTrials.gov 1 recruiting now full pipeline small index

Macular Edema: full-pipeline trial registry

1 of 15 indexed Macular Edema trials are currently recruiting.

Corpus placement: #1,140 of 28,707 conditions by registered trial count.

15 US clinical trials · 1 currently recruiting · #1,140 of 28,707 conditions by registered trial count

Macular Edema: 15 US clinical trials tracked, 1 recruiting.

Macular Edema is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is JHSPH Center for Clinical Trials, running 2 of these trials.

Enrollment posture brief

Registry condition macular-edema

OPEN 1 | RECR 7% | LATE 5 | EARLY 7 | RANK #1140 | SPON 2

Nearest open-share peer: Liver Disease (7% recruiting · 15 trials)

Advanced Lung Non-Small Cell53.3%AIDS26.7%Macular Edema (this)7%Adult Acute Myeloid Leukemia0%Adult Glioblastoma0%
Open-enrollment share among volume-matched conditions near Macular Edema

Macular Edema lists 1 open slots (7% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Macular Edema on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Macular Edema is recruiting below its size-band peers.

    1 of 15 indexed trials (6.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Macular Edema trials is spread across many organizations.

    JHSPH Center for Clinical Trials accounts for 2 of 15 trials (13.3%). 14 distinct sponsors appear on at least one study for this condition label.

  3. Most Macular Edema trials plan to enrol fewer than 100 people.

    Median target enrolment is 32 among the 15 trials that report a genuine target (sentinel values excluded). 9 of those (60%) plan for fewer than 100 participants.

  4. Macular Edema research is mostly interventional.

    14 interventional and 1 observational studies make up this index (93.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 24Phase 34Phase 41

Open and recent trials

15 total, page 1 of 1

RECRUITING Phase 2 300 participants

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

Boehringer Ingelheim

NCT06962839

ACTIVE NOT RECRUITING Phase 1 19 participants

Effect of AIV007 by Periocular Administration in Subjects with Macular Edema Secondary to Neovascular Age-related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME)

AiViva BioPharma

NCT05698329

COMPLETED Phase 3 1,260 participants

Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage

National Eye Institute (NEI)

NCT00106132

COMPLETED Phase 4 202 participants

A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion

Genentech

NCT01277302

COMPLETED Phase 3 194 participants

Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy Trial

JHSPH Center for Clinical Trials

NCT02623426

COMPLETED Phase 3 192 participants

PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial

JHSPH Center for Clinical Trials

NCT02374060

COMPLETED NA 150 participants

Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion

Barnes Retina Institute

NCT01428388

COMPLETED Phase 3 54 participants

A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina

AbbVie

NCT04976777

COMPLETED 32 participants

Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO

Optos

NCT01692938

COMPLETED NA 27 participants

Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)

Long Island Vitreoretinal Consultants

NCT01231633

COMPLETED Phase 2 22 participants

Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis

Clearside Biomedical

NCT02255032

COMPLETED Phase 1 21 participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients

Novartis Pharmaceuticals

NCT04635800

COMPLETED Phase 2 20 participants

Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema

Retina Vitreous Associates of Florida

NCT01476449

COMPLETED Phase 2 12 participants

REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study

Retina Associates of Florida, P.A.

NCT01247220

COMPLETED Phase 1 9 participants

Intravitreal Aflibercept Injection for Radiation Retinopathy

Washington University School of Medicine

NCT01579760

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 4
Phase 3 4
Phase 4 1

Named interventions

Most-linked intervention names on Macular Edema records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Ranibizumab Drug
3 trials
Intravitreal injection of ranibizumab (0.5 mg per dose) Drug
1 trials
Intravitreal injection of bevacizumab Drug
1 trials
Intravitreal Ranibizumab 0.5 mg Drug
1 trials
Intravitreal Methotrexate 400 µg Drug
1 trials
Dexamethasone intravitreal implant 0.7 mg Drug
1 trials
0.8 mg CLS-TA Drug
1 trials
4 mg CLS-TA Drug
1 trials

US sites by state

Facility locations filed on Macular Edema trials. A trial with sites in several states counts in each.

Texas 8 trials
Florida 8 trials
Maryland 7 trials
California 7 trials
North Carolina 4 trials
Missouri 4 trials
Massachusetts 4 trials
Illinois 4 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Macular Edema page

15 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Macular Edema condition card totals 15 registered trials; most-linked intervention Ranibizumab; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.