Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 1 recruiting now official registry

Macular Edema clinical trials

Every US clinical trial registered for Macular Edema — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

15 US clinical trials · 1 currently recruiting

The research picture

Macular Edema has 15 registered US clinical trials, 1 of them open to new participants right now — about 7% of the total.

1
recruiting participants now
7%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
2
top sponsor: JHSPH Center for Clinical Trials

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 2 300 participants

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

Boehringer Ingelheim

NCT06962839

ACTIVE NOT RECRUITING Phase 1 19 participants

Effect of AIV007 by Periocular Administration in Subjects with Macular Edema Secondary to Neovascular Age-related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME)

AiViva BioPharma

NCT05698329

COMPLETED Phase 3 1,260 participants

Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage

National Eye Institute (NEI)

NCT00106132

COMPLETED Phase 4 202 participants

A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion

Genentech

NCT01277302

COMPLETED Phase 3 194 participants

Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy Trial

JHSPH Center for Clinical Trials

NCT02623426

COMPLETED Phase 3 192 participants

PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial

JHSPH Center for Clinical Trials

NCT02374060

COMPLETED NA 150 participants

Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion

Barnes Retina Institute

NCT01428388

COMPLETED Phase 3 54 participants

A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina

AbbVie

NCT04976777

COMPLETED 32 participants

Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO

Optos

NCT01692938

COMPLETED NA 27 participants

Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)

Long Island Vitreoretinal Consultants

NCT01231633

COMPLETED Phase 2 22 participants

Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis

Clearside Biomedical

NCT02255032

COMPLETED Phase 1 21 participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients

Novartis Pharmaceuticals

NCT04635800

COMPLETED Phase 2 20 participants

Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema

Retina Vitreous Associates of Florida

NCT01476449

COMPLETED Phase 2 12 participants

REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study

Retina Associates of Florida, P.A.

NCT01247220

COMPLETED Phase 1 9 participants

Intravitreal Aflibercept Injection for Radiation Retinopathy

Washington University School of Medicine

NCT01579760

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 4
Phase 3 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Macular Edema Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under Macular Edema, and 1 of those are currently open to recruitment — roughly 7% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Macular Edema shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Macular Edema is led by JHSPH Center for Clinical Trials with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Macular Edema?

PlainTrial tracks 15 US clinical trials for Macular Edema, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Macular Edema?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →