Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Keratoconus: full-pipeline trial registry
14 of 22 indexed Keratoconus trials are currently recruiting.
Corpus placement: #756 of 28,707 conditions by registered trial count.
22 US clinical trials · 14 currently recruiting · #756 of 28,707 conditions by registered trial count
Keratoconus: 22 US clinical trials tracked, 14 recruiting.
Keratoconus is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Oregon Health and Science University, running 3 of these trials.
Enrollment posture brief
Registry condition keratoconus
OPEN 14 | RECR 64% | LATE 5 | EARLY 6 | RANK #756 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Autoimmune Disease (64% recruiting · 11 trials)
Keratoconus lists 14 open slots (64% of 22 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Keratoconus on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Keratoconus is recruiting above its size-band peers.
14 of 22 indexed trials (63.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Keratoconus trials is spread across many organizations.
Oregon Health and Science University accounts for 3 of 22 trials (13.6%). 17 distinct sponsors appear on at least one study for this condition label.
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Typical Keratoconus enrolment sits around 236 participants.
Median target enrolment is 236 among the 22 trials that report a genuine target (sentinel values excluded). 5 of those (22.7%) plan for fewer than 100 participants.
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Keratoconus research is mostly interventional.
16 interventional and 6 observational studies make up this index (72.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
22 total, page 1 of 1
The K-Map Study, Global Prevalence of KC
University Hospital, Geneva
NCT03115710
Comparison of Standard vs. Accelerated Corneal Crosslinking
Price Vision Group
NCT03922542
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
Goodman Eye Center
NCT04094090
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
Woolfson Eye Institute
NCT07124910
OCT in Diagnosis of Irregular Corneas
Oregon Health and Science University
NCT03504800
Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning
Cohen Laser and Vision Center
NCT05516004
Scleral Lens Fitting Using Wide-Field OCT
Oregon Health and Science University
NCT04570020
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
Woolfson Eye Institute
NCT07135167
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Massachusetts General Hospital
NCT02118922
Collagen Cross-linking in Keratoconus
Oregon Health and Science University
NCT03760432
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
Glaukos Corporation
NCT07400952
Corneal Elastography and Patient Specific Modeling
The Cleveland Clinic
NCT03030755
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
Intacs Prescription Inserts for Keratoconus Patients
University of Texas Southwestern Medical Center
NCT02138669
Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus
Epion Therapeutics
NCT06100952
Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
Epion Therapeutics
NCT06100939
McNeel Eye Center Corneal Crosslinking Study
McNeel Eye Center
NCT02921009
Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Cornea and Laser Eye Institute
NCT04698590
Initial Correction Keratoconus
University of Illinois at Chicago
NCT04918316
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Cornea Associates of Texas
NCT04667572
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
Glaukos Corporation
NCT01344187
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
Illinois College of Optometry
NCT04418999
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
| Phase 3 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Keratoconus records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Keratoconus trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Keratoconus page
22 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Keratoconus trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Oregon Health and Science University sponsors the most Keratoconus trials on record, review their full trial history before evaluating a specific study. See Oregon Health and Science University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Keratoconus condition card totals 22 registered trials; most-linked intervention Placebo and sham treatment; top US site state Ohio. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.