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Hypoxic Ischemic Encephalopathy clinical trials
9 of 14 indexed Hypoxic Ischemic Encephalopathy trials are currently recruiting.
14 US clinical trials · 9 currently recruiting
Hypoxic Ischemic Encephalopathy is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is ReAlta Life Sciences, running 1 of these trials.
The research picture
Hypoxic Ischemic Encephalopathy has 14 registered US clinical trials, 9 of them open to new participants right now, about 64% of the total.
- 9
- recruiting participants now
- 64%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 1
- top sponsor: ReAlta Life Sciences
Active & Recent Trials
14 total, page 1 of 1
Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit
Shirley Ryan AbilityLab
NCT05568264
A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures
University of California, San Diego
NCT05610085
Healthy Little Eyes
University of Wisconsin, Madison
NCT05971446
Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia
University of Florida
NCT02621944
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia
ReAlta Life Sciences
NCT05778188
The HIEnome Study: Genome Sequencing for Perinatal HIE
Baylor College of Medicine
NCT06762795
Systemic Biomarkers of Brain Injury From Hyperammonemia
Children's National Research Institute
NCT04602325
Spinal Stimulation and Mobility Devices
University of Washington
NCT05520359
Dose Optimization of Caffeine for HIE
University of North Carolina, Chapel Hill
NCT06448780
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
University of California, San Francisco
NCT05361070
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
University of Utah
NCT04772222
The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia
MaineHealth
NCT03837717
Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy
University of Southern California
NCT05130528
Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia
Seattle Children's Hospital
NCT02529202
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hypoxic Ischemic Encephalopathy Trial Landscape
14 indexed Hypoxic Ischemic Encephalopathy studies · 9 recruiting (64%).
Phase mix: 0 late (III/IV) vs 6 early (I/II).
Top sponsor: ReAlta Life Sciences (1 trial), 9 others listed. 14 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hypoxic Ischemic Encephalopathy?
PlainTrial tracks 14 US clinical trials for Hypoxic Ischemic Encephalopathy, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hypoxic Ischemic Encephalopathy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.