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ClinicalTrials.gov 9 recruiting now official registry

Hypoxic Ischemic Encephalopathy clinical trials

9 of 14 indexed Hypoxic Ischemic Encephalopathy trials are currently recruiting.

14 US clinical trials · 9 currently recruiting

Hypoxic Ischemic Encephalopathy is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is ReAlta Life Sciences, running 1 of these trials.

The research picture

Hypoxic Ischemic Encephalopathy has 14 registered US clinical trials, 9 of them open to new participants right now, about 64% of the total.

9
recruiting participants now
64%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
1
top sponsor: ReAlta Life Sciences
Phase 13Phase 23

Active & Recent Trials

14 total, page 1 of 1

RECRUITING NA 222 participants

Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit

Shirley Ryan AbilityLab

NCT05568264

RECRUITING Phase 2 133 participants

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures

University of California, San Diego

NCT05610085

RECRUITING 125 participants

Healthy Little Eyes

University of Wisconsin, Madison

NCT05971446

RECRUITING Early Phase 1 70 participants

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

University of Florida

NCT02621944

RECRUITING Phase 2 42 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

ReAlta Life Sciences

NCT05778188

RECRUITING NA 25 participants

The HIEnome Study: Genome Sequencing for Perinatal HIE

Baylor College of Medicine

NCT06762795

RECRUITING 24 participants

Systemic Biomarkers of Brain Injury From Hyperammonemia

Children's National Research Institute

NCT04602325

RECRUITING NA 20 participants

Spinal Stimulation and Mobility Devices

University of Washington

NCT05520359

RECRUITING Phase 1 16 participants

Dose Optimization of Caffeine for HIE

University of North Carolina, Chapel Hill

NCT06448780

ACTIVE NOT RECRUITING 300 participants

Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy

University of California, San Francisco

NCT05361070

COMPLETED Phase 2 50 participants

Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)

University of Utah

NCT04772222

COMPLETED NA 34 participants

The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia

MaineHealth

NCT03837717

COMPLETED NA 12 participants

Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy

University of Southern California

NCT05130528

COMPLETED Early Phase 1 7 participants

Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia

Seattle Children's Hospital

NCT02529202

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypoxic Ischemic Encephalopathy Trial Landscape

14 indexed Hypoxic Ischemic Encephalopathy studies · 9 recruiting (64%).

Phase mix: 0 late (III/IV) vs 6 early (I/II).

Top sponsor: ReAlta Life Sciences (1 trial), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypoxic Ischemic Encephalopathy?

PlainTrial tracks 14 US clinical trials for Hypoxic Ischemic Encephalopathy, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypoxic Ischemic Encephalopathy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.