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NCT06762795 · ClinicalTrials.gov registry record · NA
The HIEnome Study: Genome Sequencing for Perinatal HIE
A NA study of Hypoxic Ischemic Encephalopathy and Hypoxic Ischemic Encephalopathy (HIE), sponsored by Baylor College of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 25
- Enrollment target
- 2
- Study locations
NCT06762795: Recruiting NA study of Hypoxic Ischemic Encephalopathy and Hypoxic Ischemic Encephalopathy (HIE), sponsored by Baylor College of Medicine.
NCT06762795 is a NA study of Hypoxic Ischemic Encephalopathy and Hypoxic Ischemic Encephalopathy (HIE) that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 25 participants, below the 81-participant average among 13 other Hypoxic Ischemic Encephalopathy trials with a reported enrollment target (69% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06762795, a NA study of Hypoxic Ischemic Encephalopathy and Hypoxic Ischemic Encephalopathy (HIE), is actively recruiting participants, sponsored by Baylor College of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
- 2
- Study locations
Study Summary
Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HIE; however, it is unclear which neonates with this diagnosis warrant genetic testing. This study will offer clinical genome sequencing to neonates with HIE who are undergoing total body cooling (therapeutic hypothermia) and their parents.
Primary Outcome
The primary outcome will be the number of cases with a pathogenic or likely-pathogenic variant associated with encephalopathy. This will further be stratified by the presence or absence of a perinatal hypoxic insult or sentinel event.
Conditions Studied
Interventions
- GENETIC Genome sequencing
Study Locations (2)
Texas
- Texas Children's Hospital - Houston
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2025-05-15 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT06762795 shows while recruiting
NCT06762795 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 81-participant average among 13 other Hypoxic Ischemic Encephalopathy trials with a reported enrollment target (69% lower).
The record links to 3 conditions, with Hypoxic Ischemic Encephalopathy appearing as the primary indexed condition, and to 1 intervention - of which Genome sequencing is the first listed.
NCT06762795 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06762795 about?
NCT06762795 is a clinical study titled "The HIEnome Study: Genome Sequencing for Perinatal HIE". Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HI...
What is the current status of trial NCT06762795?
This trial is currently recruiting. It is a NA study. The enrollment target is 25 participants. The study started on 2025-05-15. Estimated completion is 2027-06-30.
What conditions does trial NCT06762795 study?
This clinical trial studies the following conditions: Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE), Hypoxic Ischemic Encephalopathy of Newborn.
What interventions are being tested in trial NCT06762795?
The interventions under investigation include: Genome sequencing (GENETIC).
Who is sponsoring clinical trial NCT06762795?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06762795 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypoxic Ischemic Encephalopathy
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Where NCT06762795's enrollment target sits among peer trials
25 9th of 13 higher than 5 of 13 other Hypoxic Ischemic Encephalopathy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypoxic Ischemic Encephalopathy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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