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ClinicalTrials.gov 13 recruiting now official registry

Hormone Receptor-Positive Breast Carcinoma clinical trials

13 of 19 indexed Hormone Receptor-Positive Breast Carcinoma trials are currently recruiting.

19 US clinical trials · 13 currently recruiting

Hormone Receptor-Positive Breast Carcinoma is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Emory University, running 3 of these trials.

The research picture

Hormone Receptor-Positive Breast Carcinoma has 19 registered US clinical trials, 13 of them open to new participants right now, about 68% of the total.

13
recruiting participants now
68%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
3
top sponsor: Emory University
Phase 14Phase 25Phase 32Phase 41

Active & Recent Trials

19 total, page 1 of 1

RECRUITING Phase 3 3,680 participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

National Cancer Institute (NCI)

NCT06058377

RECRUITING 1,600 participants

National Cancer Institute "Cancer Moonshot Biobank"

National Cancer Institute (NCI)

NCT04314401

RECRUITING NA 410 participants

Mobile Health for Adherence in Breast Cancer Patients

ECOG-ACRIN Cancer Research Group

NCT06112613

RECRUITING Phase 1 300 participants

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

BeiGene

NCT06120283

RECRUITING NA 150 participants

Acutherapy to Prevent Aromatase Inhibitor-Associated Arthralgias in Non-Hispanic Black Postmenopausal Women With Early-Stage Breast Cancer

Emory University

NCT06534125

RECRUITING 100 participants

The Sleep After Breast Cancer (ABC) Study - Examining Sleep Changes and Biomarkers Among Breast Cancer Patients

Ohio State University Comprehensive Cancer Center

NCT07341503

RECRUITING Phase 2 88 participants

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Jonsson Comprehensive Cancer Center

NCT04553770

RECRUITING Phase 4 60 participants

A Study of Revaree Plus in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT07042581

RECRUITING NA 55 participants

Neoadjuvant Breast Cancer Time Restricted Eating

Thomas Jefferson University

NCT05327608

RECRUITING Phase 2 43 participants

Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

City of Hope Medical Center

NCT04305834

RECRUITING Early Phase 1 40 participants

Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer

Emory University

NCT05464810

RECRUITING Phase 2 38 participants

5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

Mayo Clinic

NCT07044310

RECRUITING NA 30 participants

A Feasibility Trial of a Web Based App Intervention in Hormone Positive Breast Cancer Patients to Improve Adherence to Endocrine Therapy

Emory University

NCT05488145

ACTIVE NOT RECRUITING Phase 3 1,167 participants

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Alliance for Clinical Trials in Oncology

NCT04379570

ACTIVE NOT RECRUITING NA 565 participants

Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study

SWOG Cancer Research Network

NCT05568472

ACTIVE NOT RECRUITING Phase 1 325 participants

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

Exelixis

NCT03845166

ACTIVE NOT RECRUITING Phase 2 138 participants

Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study

ECOG-ACRIN Cancer Research Group

NCT04316117

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING Phase 2 44 participants

Alpelisib (BYL719) in Combination With Continued Endocrine Therapy Following Progression on Endocrine Therapy in Hormone Receptor Positive, HER2 Negative, PIK3CA Mutant Metastatic Breast Cancer

Marina N Sharifi

NCT04762979

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 5
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hormone Receptor-Positive Breast Carcinoma Trial Landscape

19 indexed Hormone Receptor-Positive Breast Carcinoma studies · 13 recruiting (68%).

Phase mix: 3 late (III/IV) vs 9 early (I/II).

Top sponsor: Emory University (3 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hormone Receptor-Positive Breast Carcinoma?

PlainTrial tracks 19 US clinical trials for Hormone Receptor-Positive Breast Carcinoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hormone Receptor-Positive Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.