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ClinicalTrials.gov 17 recruiting now official registry

High Grade B-Cell Lymphoma clinical trials

17 of 26 indexed High Grade B-Cell Lymphoma trials are currently recruiting.

26 US clinical trials · 17 currently recruiting

High Grade B-Cell Lymphoma is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 4 of these trials.

The research picture

High Grade B-Cell Lymphoma has 26 registered US clinical trials, 17 of them open to new participants right now, about 65% of the total.

17
recruiting participants now
65%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 115Phase 27

Active & Recent Trials

26 total, page 1 of 1

RECRUITING Phase 1 317 participants

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

AstraZeneca

NCT04594642

RECRUITING Phase 2 227 participants

Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

SWOG Cancer Research Network

NCT05890352

RECRUITING 154 participants

Study of CAR-T Therapy in Older Patients

Memorial Sloan Kettering Cancer Center

NCT04300998

RECRUITING Phase 1 120 participants

P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies

Poseida Therapeutics

NCT06014762

RECRUITING Phase 1 56 participants

A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)

ADC Therapeutics S.A.

NCT05660395

RECRUITING Phase 2 50 participants

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT06736613

RECRUITING Phase 1 42 participants

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

Acepodia Biotech

NCT05653271

RECRUITING Phase 2 42 participants

A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT06765317

RECRUITING NA 40 participants

ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL

Hua-Jay J Cherng, MD

NCT06693830

RECRUITING Phase 1 35 participants

Tafasitamab, Retifanlimab, and Rituximab in Combination With Standard Therapy for the Treatment of Diffuse Large B-cell Lymphoma

University of Washington

NCT05455697

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 31 participants

Epcoritamab-CAR T Cells for Large B-cell Lymphomas

Abramson Cancer Center at Penn Medicine

NCT06458439

RECRUITING Phase 1 30 participants

Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma

OHSU Knight Cancer Institute

NCT06249191

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 1 24 participants

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

Jonsson Comprehensive Cancer Center

NCT05256641

RECRUITING Phase 1 15 participants

Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

Washington University School of Medicine

NCT05412290

ACTIVE NOT RECRUITING NA 73 participants

Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell Lymphoma

Ohio State University Comprehensive Cancer Center

NCT03656835

ACTIVE NOT RECRUITING Phase 2 51 participants

Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

University of Chicago

NCT03995147

ACTIVE NOT RECRUITING Phase 1 33 participants

Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma

University of Nebraska

NCT05621096

ACTIVE NOT RECRUITING Phase 1 30 participants

Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05757700

ACTIVE NOT RECRUITING Phase 1 24 participants

Mosunetuzumab in Combination With Platinum-Based Salvage Chemotherapy in Patients With Relapsed/Refractory Aggressive B Cell Lymphoma

Washington University School of Medicine

NCT05464329

ACTIVE NOT RECRUITING Phase 1 23 participants

Acalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphoma

University of Washington

NCT04257578

ACTIVE NOT RECRUITING Phase 2 8 participants

Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma

Barbara Ann Karmanos Cancer Institute

NCT04479267

COMPLETED Phase 1 39 participants

A Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory DLBCL and/or High-Grade B-Cell Lymphoma and/or High Grade B-Cell Lymphoma With MYC and/or BCL2 and/or BCL6

Hoffmann-La Roche

NCT03255096

COMPLETED NA 10 participants

Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)

Massachusetts General Hospital

NCT06004167

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the High Grade B-Cell Lymphoma Trial Landscape

26 indexed High Grade B-Cell Lymphoma studies · 17 recruiting (65%).

Phase mix: 0 late (III/IV) vs 22 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (4 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for High Grade B-Cell Lymphoma?

PlainTrial tracks 26 US clinical trials for High Grade B-Cell Lymphoma, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for High Grade B-Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.