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ClinicalTrials.gov 2 recruiting now official registry

Hepatosplenic T-cell Lymphoma clinical trials

2 of 13 indexed Hepatosplenic T-cell Lymphoma trials are currently recruiting.

13 US clinical trials · 2 currently recruiting

Hepatosplenic T-cell Lymphoma is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.

The research picture

Hepatosplenic T-cell Lymphoma has 13 registered US clinical trials, 2 of them open to new participants right now, about 15% of the total.

2
recruiting participants now
15%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: National Cancer Institute (NCI)
Phase 17Phase 25

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 1 69 participants

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Dren Bio

NCT05475925

RECRUITING Phase 1 60 participants

A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL)

National Cancer Institute (NCI)

NCT07055477

ACTIVE NOT RECRUITING NA 565 participants

Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency

Mayo Clinic

NCT01787409

ACTIVE NOT RECRUITING Phase 2 48 participants

Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma

City of Hope Medical Center

NCT03113500

ACTIVE NOT RECRUITING Phase 2 30 participants

Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma

Northwestern University

NCT02232516

COMPLETED Phase 1 124 participants

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

Mayo Clinic

NCT00918333

COMPLETED Phase 2 60 participants

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

National Cancer Institute (NCI)

NCT01258998

COMPLETED Phase 1 54 participants

Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma

University of Nebraska

NCT02561273

COMPLETED Phase 1 43 participants

Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors

National Cancer Institute (NCI)

NCT01326702

COMPLETED Phase 2 41 participants

Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Mayo Clinic

NCT01261247

COMPLETED Phase 1 20 participants

Methoxyamine and Fludarabine Phosphate in Treating Patients With Relapsed or Refractory Hematologic Malignancies

Case Comprehensive Cancer Center

NCT01658319

COMPLETED Phase 2 14 participants

Sorafenib Tosylate in Treating Patients With Recurrent Aggressive Non-Hodgkin's Lymphoma

National Cancer Institute (NCI)

NCT00131937

COMPLETED Phase 1 8 participants

Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma

Pierluigi Porcu

NCT01129180

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatosplenic T-cell Lymphoma Trial Landscape

13 indexed Hepatosplenic T-cell Lymphoma studies · 2 recruiting (15%).

Phase mix: 0 late (III/IV) vs 12 early (I/II).

Top sponsor: National Cancer Institute (NCI) (4 trials), 7 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatosplenic T-cell Lymphoma?

PlainTrial tracks 13 US clinical trials for Hepatosplenic T-cell Lymphoma, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatosplenic T-cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.