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ClinicalTrials.gov 2 recruiting now early-phase tilt small index

Hepatosplenic T-cell Lymphoma: early-phase trial registry

2 of 13 indexed Hepatosplenic T-cell Lymphoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,315 of 28,707 conditions by registered trial count.

13 US clinical trials · 2 currently recruiting · #1,315 of 28,707 conditions by registered trial count

Hepatosplenic T-cell Lymphoma: 13 US clinical trials tracked, 2 recruiting.

Hepatosplenic T-cell Lymphoma is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.

Enrollment posture brief

Registry condition hepatosplenic-t-cell-lymphoma

OPEN 2 | RECR 15% | LATE 0 | EARLY 12 | RANK #1315 | SPON 4

Nearest open-share peer: Arthroplasty, Replacement, Knee (15% recruiting · 13 trials)

ACL Injury61.5%Acute Biphenotypic Leukemia46.2%Accidental Falls30.8%Actinic Keratoses23.1%Hepatosplenic T-cell Lym (th…15%
Open-enrollment share among volume-matched conditions near Hepatosplenic T-cell Lymphoma

Hepatosplenic T-cell Lymphoma lists 2 open slots (15% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Hepatosplenic T-cell Lymphoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Hepatosplenic T-cell Lymphoma is recruiting below its size-band peers.

    2 of 13 indexed trials (15.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Hepatosplenic T-cell Lymphoma research.

    National Cancer Institute (NCI) accounts for 4 of 13 trials (30.8%). 8 distinct sponsors appear on at least one study for this condition label.

  3. Most Hepatosplenic T-cell Lymphoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 48 among the 13 trials that report a genuine target (sentinel values excluded). 11 of those (84.6%) plan for fewer than 100 participants.

  4. Hepatosplenic T-cell Lymphoma research is mostly interventional.

    13 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 17Phase 25

Open and recent trials

13 total, page 1 of 1

RECRUITING Phase 1 69 participants

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Dren Bio

NCT05475925

RECRUITING Phase 1 60 participants

A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL)

National Cancer Institute (NCI)

NCT07055477

ACTIVE NOT RECRUITING NA 565 participants

Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency

Mayo Clinic

NCT01787409

ACTIVE NOT RECRUITING Phase 2 48 participants

Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma

City of Hope Medical Center

NCT03113500

ACTIVE NOT RECRUITING Phase 2 30 participants

Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma

Northwestern University

NCT02232516

COMPLETED Phase 1 124 participants

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

Mayo Clinic

NCT00918333

COMPLETED Phase 2 60 participants

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

National Cancer Institute (NCI)

NCT01258998

COMPLETED Phase 1 54 participants

Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma

University of Nebraska

NCT02561273

COMPLETED Phase 1 43 participants

Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors

National Cancer Institute (NCI)

NCT01326702

COMPLETED Phase 2 41 participants

Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Mayo Clinic

NCT01261247

COMPLETED Phase 1 20 participants

Methoxyamine and Fludarabine Phosphate in Treating Patients With Relapsed or Refractory Hematologic Malignancies

Case Comprehensive Cancer Center

NCT01658319

COMPLETED Phase 2 14 participants

Sorafenib Tosylate in Treating Patients With Recurrent Aggressive Non-Hodgkin's Lymphoma

National Cancer Institute (NCI)

NCT00131937

COMPLETED Phase 1 8 participants

Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma

Pierluigi Porcu

NCT01129180

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 5

Named interventions

Most-linked intervention names on Hepatosplenic T-cell Lymphoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

laboratory biomarker analysis Other
5 trials
Cyclophosphamide Drug
3 trials
western blotting Genetic
2 trials
pharmacological study Other
2 trials
panobinostat Drug
2 trials
Etoposide Drug
2 trials
Doxorubicin Hydrochloride Drug
2 trials
Laboratory Biomarker Analysis Other
2 trials

US sites by state

Facility locations filed on Hepatosplenic T-cell Lymphoma trials. A trial with sites in several states counts in each.

Ohio 4 trials
New York 4 trials
Minnesota 4 trials
California 4 trials
Texas 3 trials
Arizona 3 trials
Washington 2 trials
Missouri 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Hepatosplenic T-cell Lymphoma page

13 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hepatosplenic T-cell Lymphoma condition card totals 13 registered trials; most-linked intervention laboratory biomarker analysis; top US site state Ohio. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.