Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma

NCT02561273 · View on ClinicalTrials.gov ↗

Study Summary

This phase I/II trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy and to see how well they work in treating patients with newly diagnosed stage II-IV peripheral T-cell non-Hodgkin's lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stop the growth of peripheral T-cell non-Hodgkin's lymphoma by blocking the growth of new blood vessels necessary for cancer growth. Giving combination chemotherapy with lenalidomide may be a better treatment for peripheral T-cell non-Hodgkin's lymphoma.

Interventions

  • DRUG Cyclophosphamide
  • OTHER Laboratory Biomarker Analysis
  • DRUG Doxorubicin Hydrochloride
  • DRUG Etoposide
  • PROCEDURE Autologous Hematopoietic Stem Cell Transplantation

Study Locations (8)

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • Stanford Cancer Institute — Palo Alto

Colorado

  • University of Colorado Cancer Center, Anschutz Cancer Pavilion — Aurora

Georgia

  • Emory University/Winship Cancer Institute — Atlanta

Minnesota

  • Mayo Clinic — Rochester

Missouri

  • Washington University School of Medicine — St Louis

Nebraska

  • University of Nebraska Medical Center — Omaha

New York

  • Memorial Sloan-Kettering Cancer Center — New York

Trial Details

FieldValue
Enrollment Target 54 participants
Start Date 2015-09-28
Est. Completion 2020-11-01
Phase Phase 1

Sponsor

University of Nebraska

272 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02561273

The ClinicalTrials.gov registry entry for NCT02561273 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Nebraska, which has 272 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Anaplastic Large Cell Lymphoma, ALK-Positive appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02561273 reports 8 study locations spanning 7 distinct geographic areas — top geographies include California, Colorado, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02561273 about?

NCT02561273 is a clinical study titled "Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma". This phase I/II trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy and to see how well they work in treating patients with newly diagnosed stage II-IV peripheral T-cell non-Hodgkin's lymphoma. Drugs used in chemotherapy, such as cyclophosph...

What is the current status of trial NCT02561273?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 54 participants. The study started on 2015-09-28. Estimated completion is 2020-11-01.

What conditions does trial NCT02561273 study?

This clinical trial studies the following conditions: Anaplastic Large Cell Lymphoma, ALK-Positive, Peripheral T-Cell Lymphoma, Not Otherwise Specified, Hepatosplenic T-Cell Lymphoma, Anaplastic Large Cell Lymphoma, ALK-Negative, Stage II Angioimmunoblastic T-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02561273?

The interventions under investigation include: Cyclophosphamide (DRUG), Laboratory Biomarker Analysis (OTHER), Doxorubicin Hydrochloride (DRUG), Etoposide (DRUG), Autologous Hematopoietic Stem Cell Transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02561273?

This trial is sponsored by University of Nebraska, which has 272 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02561273 being conducted?

This trial has 8 study locations across California, Colorado, Georgia, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial