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Heart Failure, Systolic clinical trials
Every US clinical trial registered for Heart Failure, Systolic — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
13 US clinical trials · 7 currently recruiting
The research picture
Heart Failure, Systolic has 13 registered US clinical trials, 7 of them open to new participants right now — about 54% of the total.
- 7
- recruiting participants now
- 54%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 1
- top sponsor: Sardocor
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
University of California, San Francis
NCT05933083
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Procyrion
NCT05677100
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
University of Virginia
NCT06009276
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Sardocor
NCT04703842
Paced Heart Rate Acceleration for Cardiac Conditioning
Denice Hodgson-Zingman, MD
NCT06332391
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Medical College of Wisconsin
NCT05752760
Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells
BioCardia
NCT05925608
Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure
University of Washington
NCT04528004
AB-1002 in Patients With Class III Heart Failure
AskBio
NCT04179643
Hemodynamic-GUIDEd Management of Heart Failure
Abbott Medical Devices
NCT03387813
Virtual Visits to Optimize Research Trial Offerings to HF Patients
The Cleveland Clinic
NCT04064541
SGLT2 Inhibition in Diabetes and Heart Failure
Virginia Commonwealth University
NCT02862067
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Failure, Systolic Trial Landscape
ClinicalTrials.gov lists 13 US studies indexed under Heart Failure, Systolic, and 7 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Heart Failure, Systolic shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Heart Failure, Systolic is led by Sardocor with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Failure, Systolic?
PlainTrial tracks 13 US clinical trials for Heart Failure, Systolic, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Failure, Systolic?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.