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2026 data Public-data reference. official source

Head and Neck Neoplasms

Open-data reference.

24 US clinical trials · 12 currently recruiting

Active & Recent Trials

RECRUITING 1,000 participants

NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

National Institute on Deafness and Other Communication Disorders (NIDCD)

NCT06303180

RECRUITING 1,000 participants

Molecular and Genomic Profiling of Head and Neck Tumors

Montefiore Medical Center

NCT00200486

RECRUITING 1,000 participants

Biospecimen Procurement for Head and Neck Disorders

National Cancer Institute (NCI)

NCT03429036

RECRUITING Phase 1 403 participants

First in Human Study of AZD9592 in Solid Tumors

AstraZeneca

NCT05647122

RECRUITING NA 352 participants

The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

Medical University of South Carolina

NCT05811936

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING Phase 4 100 participants

DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment

Rutgers, The State University of New Jersey

NCT07158164

RECRUITING Phase 1 36 participants

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

University of Chicago

NCT06912087

RECRUITING NA 30 participants

EMST in Patients Undergoing CRT for HNCA

University of Wisconsin, Milwaukee

NCT03916809

RECRUITING Phase 2 30 participants

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

University of Chicago

NCT05420948

RECRUITING Phase 3 20 participants

Head and Neck Cancer Study Project in the Geriatric Population

Brown University

NCT06998069

RECRUITING Phase 2 12 participants

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT05544136

ACTIVE NOT RECRUITING Phase 3 714 participants

Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)

Merck Sharp & Dohme

NCT03765918

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 2 120 participants

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

Seagen, a wholly owned subsidiary of Pfizer

NCT06003231

ACTIVE NOT RECRUITING Phase 1 42 participants

Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer

University of Chicago

NCT06110195

ACTIVE NOT RECRUITING Phase 1 15 participants

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

M.D. Anderson Cancer Center

NCT06237881

COMPLETED Phase 2 195 participants

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

UNC Lineberger Comprehensive Cancer Center

NCT03077243

COMPLETED Phase 2 78 participants

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

University of California, San Diego

NCT03082534

COMPLETED Phase 2 37 participants

A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...

National Cancer Institute (NCI)

NCT00923481

COMPLETED Phase 2 33 participants

F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients

University of Iowa

NCT00721799

COMPLETED NA 30 participants

Image-guided Cryoablation of Head, Neck and Spine Tumors

Dana-Farber Cancer Institute

NCT02085941

COMPLETED Phase 1 29 participants

C-TPF in Patients With Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Dana-Farber Cancer Institute

NCT00402545

COMPLETED Phase 1 9 participants

Study of Intralesional Injection of M4N in Patients With Refractory Malignant Tumors of the Head and Neck

Erimos Pharmaceuticals

NCT00057512

Phase Distribution

PhaseTrial count
Early Phase 1 7
Phase 2 8
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Head and Neck Neoplasms Trial Landscape

ClinicalTrials.gov lists 24 US studies indexed under Head and Neck Neoplasms, and 12 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Head and Neck Neoplasms shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Head and Neck Neoplasms is led by University of Chicago with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 24 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Head and Neck Neoplasms?

PlainTrial tracks 24 US clinical trials for Head and Neck Neoplasms, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Head and Neck Neoplasms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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