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NCT06998069 · ClinicalTrials.gov registry record · Phase 3

Head and Neck Cancer Study Project in the Geriatric Population

A Phase 3 study of Head and Neck Neoplasms, sponsored by Brown University.

Recruiting
Registry status
Phase 3
Development phase
20
Enrollment target
1
Study location

NCT06998069 is a Phase 3 study of Head and Neck Neoplasms that is actively recruiting participants, run by Brown University. The registered enrollment target is 20 participants, below the 265-participant average among 23 other Head and Neck Neoplasms trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06998069, a Phase 3 study of Head and Neck Neoplasms, is actively recruiting participants, sponsored by Brown University.

RECRUITING
Registry status
Phase 3
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a novel reduced intensity regimen. The regimen will be tailored based on the programmed cell death ligand 1 combined positive score (PD-L1 CPS) and will involve 4 cycles of systemic chemotherapy and/or immunotherapy followed by radiation treatment.

Conditions Studied

Head and Neck Neoplasms

Interventions

  • DRUG Arm I Carboplatin, Paclitaxel, Pembrolizumab
  • DRUG Arm II Carboplatin, Paclitaxel, Cetuximab
  • DRUG Arm III Pembrolizumab

Study Locations (1)

Rhode Island

  • Rhode Island and The Miriam Hospitals - Providence

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2025-08-27
Est. Completion 2027-06-01
Phase Phase 3

Sponsor

Brown University

231 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06998069

The ClinicalTrials.gov registry entry for NCT06998069 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 265-participant average among 23 other Head and Neck Neoplasms trials with a reported enrollment target (92% lower). The listed sponsor is Brown University, which has 231 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Head and Neck Neoplasms appearing as the primary indexed condition, and to 3 interventions - of which Arm I Carboplatin, Paclitaxel, Pembrolizumab is the first listed.

NCT06998069 reports 1 study location spanning 1 distinct geographic area - top geographies include Rhode Island.

Frequently Asked Questions

What is clinical trial NCT06998069 about?

NCT06998069 is a clinical study titled "Head and Neck Cancer Study Project in the Geriatric Population". This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a n...

What is the current status of trial NCT06998069?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 20 participants. The study started on 2025-08-27. Estimated completion is 2027-06-01.

What conditions does trial NCT06998069 study?

This clinical trial studies the following conditions: Head and Neck Neoplasms.

What interventions are being tested in trial NCT06998069?

The interventions under investigation include: Arm I Carboplatin, Paclitaxel, Pembrolizumab (DRUG), Arm II Carboplatin, Paclitaxel, Cetuximab (DRUG), Arm III Pembrolizumab (DRUG).

Who is sponsoring clinical trial NCT06998069?

This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06998069 being conducted?

This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.