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NCT06998069 · ClinicalTrials.gov registry record · Phase 3
Head and Neck Cancer Study Project in the Geriatric Population
A Phase 3 study of Head and Neck Neoplasms, sponsored by Brown University.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06998069: Recruiting Phase 3 study of Head and Neck Neoplasms, sponsored by Brown University.
NCT06998069 is a Phase 3 study of Head and Neck Neoplasms that is actively recruiting participants, run by Brown University. The registered enrollment target is 20 participants, below the 265-participant average among 23 other Head and Neck Neoplasms trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06998069, a Phase 3 study of Head and Neck Neoplasms, is actively recruiting participants, sponsored by Brown University.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a novel reduced intensity regimen. The regimen will be tailored based on the programmed cell death ligand 1 combined positive score (PD-L1 CPS) and will involve 4 cycles of systemic chemotherapy and/or immunotherapy followed by radiation treatment.
Primary Outcome
Number of participants who complete 4 cycles of systemic therapy followed by one week of radiation therapy within 14 weeks from start of therapy
Conditions Studied
Interventions
- DRUG Arm I Carboplatin, Paclitaxel, Pembrolizumab
- DRUG Arm II Carboplatin, Paclitaxel, Cetuximab
- DRUG Arm III Pembrolizumab
Study Locations (1)
Rhode Island
- Rhode Island and The Miriam Hospitals - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-08-27 |
| Est. Completion | 2027-06-01 |
| Phase | Phase 3 |
What NCT06998069 shows while recruiting
NCT06998069 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 265-participant average among 23 other Head and Neck Neoplasms trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Head and Neck Neoplasms appearing as the primary indexed condition, and to 3 interventions - of which Arm I Carboplatin, Paclitaxel, Pembrolizumab is the first listed.
NCT06998069 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT06998069 about?
NCT06998069 is a clinical study titled "Head and Neck Cancer Study Project in the Geriatric Population". This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a n...
What is the current status of trial NCT06998069?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 20 participants. The study started on 2025-08-27. Estimated completion is 2027-06-01.
What conditions does trial NCT06998069 study?
This clinical trial studies the following conditions: Head and Neck Neoplasms.
What interventions are being tested in trial NCT06998069?
The interventions under investigation include: Arm I Carboplatin, Paclitaxel, Pembrolizumab (DRUG), Arm II Carboplatin, Paclitaxel, Cetuximab (DRUG), Arm III Pembrolizumab (DRUG).
Who is sponsoring clinical trial NCT06998069?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06998069 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Head and Neck Neoplasms
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Where NCT06998069's enrollment target sits among peer trials
20 21st of 23 higher than 3 of 23 other Head and Neck Neoplasms trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Head and Neck Neoplasms trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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