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Glaucoma Open-Angle clinical trials
11 of 24 indexed Glaucoma Open-Angle trials are currently recruiting.
24 US clinical trials · 11 currently recruiting
Glaucoma Open-Angle is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Glaukos Corporation, running 4 of these trials.
The research picture
Glaucoma Open-Angle has 24 registered US clinical trials, 11 of them open to new participants right now, about 46% of the total.
- 11
- recruiting participants now
- 46%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Glaukos Corporation
Active & Recent Trials
24 total, page 1 of 1
A Trial of Hydrus Microstent Versus Goniotomy
Massachusetts Eye and Ear Infirmary
NCT06289491
Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone
Glaukos Corporation
NCT06066645
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
Amneal Pharmaceuticals
NCT05401357
Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone
Glaukos Corporation
NCT06848946
Optic Nerve Head Strain as Biomarker for Glaucoma
Johns Hopkins University
NCT06240312
24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring
Smartlens
NCT06689696
Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension
PolyActiva Pty
NCT06964191
Electrical Stimulation for the Treatment of Glaucoma
Stanford University
NCT05626491
Electrical Stimulation for the Treatment of Optic Neuropathies
Stanford University
NCT05626426
Electrical Stimulation for Vision Neuroenhancement in Glaucoma
Stanford University
NCT06685211
Results of Patients With Glaucoma Undergoing Minimally Invasive Glaucoma Surgery in Conjunction With Cataract Surgery
Vold Vision P.L.L.C
NCT05624398
iStent Inject New Enrollment Post-Approval Study
Glaukos Corporation
NCT04624698
Clinical Outcomes in Cataract Surgery With OMNI Canaloplasty vs Cataract Surgery With OMNI Canaloplasty and Hydrus Stent
Ridge Eye Care
NCT05949242
Use of Methazolamide to Lower Intraocular Pressure
University of Colorado, Denver
NCT05498103
Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension
Allergan
NCT02247804
Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5%
Glaukos Corporation
NCT03519386
Pigment Dispersion Syndrome With and Without Glaucoma
National Eye Institute (NEI)
NCT00001152
Ocular Surface Tolerability Study of Prostaglandin Analogues in Patients With Open-Angle Glaucoma or Ocular Hypertension
Allergan
NCT01253902
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma
Chicago Center for Vision Research
NCT00317577
A Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System
Sight Sciences
NCT05044793
Negative Pressure Applied by the Equinox MPD for Severe Open Angle Glaucoma
Equinox
NCT04632329
Safety and Efficacy of a Glaucoma Drug Delivery System
Vistakon Pharmaceuticals
NCT00824720
Evaluating Home Testing Devices for the Management of Glaucoma
Wills Eye
NCT05325996
A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT)
Alcon Research
NCT00051155
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 3 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Glaucoma Open-Angle Trial Landscape
24 indexed Glaucoma Open-Angle studies · 11 recruiting (46%).
Phase mix: 8 late (III/IV) vs 3 early (I/II).
Top sponsor: Glaukos Corporation (4 trials), 9 others listed. 24 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Glaucoma Open-Angle?
PlainTrial tracks 24 US clinical trials for Glaucoma Open-Angle, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Glaucoma Open-Angle?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.