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NCT04661215 · ClinicalTrials.gov registry record

Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms

A clinical trial of Gastroparesis and Diabetic Gastroparesis, sponsored by Johns Hopkins Bloomberg School of Public Health.

Recruiting
Registry status
150
Enrollment target
6
Study locations

NCT04661215: Recruiting study of Gastroparesis and Diabetic Gastroparesis, sponsored by Johns Hopkins Bloomberg School of Public Health.

NCT04661215 is a study of Gastroparesis and Diabetic Gastroparesis that is actively recruiting participants, run by Johns Hopkins Bloomberg School of Public Health. The registered enrollment target is 150 participants, below the 299-participant average among 44 other Gastroparesis trials with a reported enrollment target (50% lower). The trial reports 6 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04661215, a study of Gastroparesis and Diabetic Gastroparesis, is actively recruiting participants, sponsored by Johns Hopkins Bloomberg School of Public Health.

RECRUITING
Registry status
150 participants
Enrollment target
6
Study locations

Study Summary

The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric sphincter - endoluminal functional luminal imaging probe (Endoflip™), water load satiety testing (WLST), and high-resolution cutaneous electrogastrography (HR-EGG) using Gastric Alimetry™ System.

Primary Outcome

Distensibility of the pylorus will be calculated as the median of three measurements (not three different inflations) of distensibility (mm2/mmHg) of the pylorus pressure using the Endoflip balloon catheter at 50 mL volume

Conditions Studied

Gastroparesis Diabetic Gastroparesis Idiopathic Gastric Motility Disorder

Study Locations (6)

Arizona

  • Mayo Clinic Arizona - Scottsdale

Kentucky

  • University of Louisville - Louisville

Massachusetts

  • Massachusetts General - Boston

North Carolina

  • Wake Forest University Health Sciences - Winston-Salem

Pennsylvania

  • Temple University - Philadelphia

Texas

  • Texas Tech University Health Science Center (TTUHSC) - El Paso

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2026-01-13
Est. Completion 2027-04-15
Johns Hopkins Bloomberg School of Public Health

187 total trials

What NCT04661215 shows while recruiting

NCT04661215 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 299-participant average among 44 other Gastroparesis trials with a reported enrollment target (50% lower).

The record links to 3 conditions, with Gastroparesis appearing as the primary indexed condition, and to 0 interventions.

NCT04661215 lists 6 locations in 6 states (Arizona, Kentucky, Massachusetts).

Frequently Asked Questions

What is clinical trial NCT04661215 about?

NCT04661215 is a clinical study titled "Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms". The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric sphincter - endoluminal functional luminal imaging probe (Endoflip™), water l...

What is the current status of trial NCT04661215?

This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2026-01-13. Estimated completion is 2027-04-15.

What conditions does trial NCT04661215 study?

This clinical trial studies the following conditions: Gastroparesis, Diabetic Gastroparesis, Idiopathic Gastric Motility Disorder.

Who is sponsoring clinical trial NCT04661215?

This trial is sponsored by Johns Hopkins Bloomberg School of Public Health, which has 187 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04661215 being conducted?

This trial has 6 study locations across Arizona, Kentucky, Massachusetts, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Gastroparesis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04661215's enrollment target sits among peer trials

150 15th of 44 higher than 30 of 44 other Gastroparesis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Gastroparesis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04661215

Source: ClinicalTrials.gov NCT04661215, the US trial registry maintained by the National Library of Medicine. NCT04661215 (mid enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.