Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Gastrointestinal Cancer
Open-data reference.
49 US clinical trials · 30 currently recruiting
Active & Recent Trials
Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05995821
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Revolution Medicines
NCT06445062
The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care
University of Chicago
NCT04541381
BOLSTER: Learning New Skills to Thrive
Dana-Farber Cancer Institute
NCT06936878
Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer
National Cancer Institute (NCI)
NCT01313442
Improving Comprehensive Care of Cancer Patients
Baylor College of Medicine
NCT05323409
REmote Symptom COllection to improVE postopeRative Care
Medstar Health Research Institute
NCT06190730
Resilience and Equity in Aging, Cancer, and Health (REACH)
Dana-Farber Cancer Institute
NCT04674267
A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers
Memorial Sloan Kettering Cancer Center
NCT05789485
SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention)
Nadine McCleary, MD, MPH
NCT05375643
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
National Cancer Institute (NCI)
NCT06253520
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Case Comprehensive Cancer Center
NCT06263088
Goals of Care Discussion for Patients With Advanced Lung and Gastrointestinal Cancer in the Emergency Department of a Comprehensive Cancer Center
M.D. Anderson Cancer Center
NCT06420206
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Merck Sharp & Dohme
NCT06596694
Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies
UNC Lineberger Comprehensive Cancer Center
NCT05743426
Dyadic Sleep Study
University of Miami
NCT06569693
EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
Orlando Health
NCT06340620
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
University of California, San Francis
NCT06633224
Evaluating Microarray Pharmacogenetic Testing in Cancer Patients
Wake Forest University Health Sciences
NCT06489041
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
National Cancer Institute (NCI)
NCT03190941
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Nammi Therapeutics
NCT06582017
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Washington University School of Medicine
NCT04354064
Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology
H. Lee Moffitt Cancer Center and Research Institute
NCT05664178
ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy
Abramson Cancer Center at Penn Medicine
NCT05318027
Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies
National Cancer Institute (NCI)
NCT04847063
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Memorial Sloan Kettering Cancer Center
NCT05837767
Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy
Henry Ford Health System
NCT06065371
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
Fox Chase Cancer Center
NCT05274048
Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)
Cedars-Sinai Medical Center
NCT07124351
PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis
University of California, Irvine
NCT06511037
Pathways to Advance Targeted and Helpful Serious Illness Conversations (PATH-SIC)
Dana-Farber Cancer Institute
NCT05629065
A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)
Merck Sharp & Dohme
NCT06864169
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Brigham and Women's Hospital
NCT04899908
Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery
The Guthrie Clinic
NCT05694338
Real World Treatment Experience of Patients With Breast, Lung, or GI Cancer or Multiple Myeloma Using Remote Symptom Monitoring
Carevive Systems
NCT05587972
Advancing Nursing Practices in Hospital Oncology Care
Memorial Sloan Kettering Cancer Center
NCT05053191
Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population
University of Oklahoma
NCT05863052
Avatrombopag vs. Placebo for CIT in GI Malignancies
Hanny Al-Samkari, MD
NCT05772546
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
University of Nebraska
NCT05220046
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
City of Hope Medical Center
NCT02293954
Effectiveness of Lay Navigators in Meeting Cancer Patients' Non-Clinical Needs: A Pilot Study
Stanford University
NCT03245788
Perioperative Palliative Care Surrounding Cancer Surgery for Patients & Their Family Members
Stanford University
NCT03611309
Routine Evaluation of the Social Determinants of Health in Oncology: User-centered Resource Coordination and Engagement
Dana-Farber Cancer Institute
NCT04879927
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Rocking Motion: Physiologic Effect on the Surgical Stress Response
M.D. Anderson Cancer Center
NCT01200316
Oxaliplatin With FOLFOX4 in Patients With Normal and Abnormal Renal Function
Sanofi
NCT00094965
Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Metastatic Gastric Cancer
M.D. Anderson Cancer Center
NCT02092298
CAPOX in KRAS Wild-Type Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater
M.D. Anderson Cancer Center
NCT01202409
The Science of the Art of Palliative Care
Dartmouth-Hitchcock Medical Center
NCT05137782
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 12 |
| Phase 2 | 8 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Gastrointestinal Cancer Trial Landscape
ClinicalTrials.gov lists 49 US studies indexed under Gastrointestinal Cancer, and 30 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Gastrointestinal Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Gastrointestinal Cancer is led by Dana-Farber Cancer Institute with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 49 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Gastrointestinal Cancer?
PlainTrial tracks 49 US clinical trials for Gastrointestinal Cancer, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Gastrointestinal Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.