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ClinicalTrials.gov 28 recruiting now official registry

Marginal Zone Lymphoma clinical trials

Every US clinical trial registered for Marginal Zone Lymphoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

50 US clinical trials · 28 currently recruiting

The research picture

Marginal Zone Lymphoma has 50 registered US clinical trials, 28 of them open to new participants right now — about 56% of the total.

28
recruiting participants now
56%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
4
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 780 participants

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

BeiGene

NCT05100862

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING Phase 3 375 participants

A Study of Reduced Dose Radiation Therapy for People With B-Cell Lymphomas

Memorial Sloan Kettering Cancer Center

NCT07029217

RECRUITING Phase 1 148 participants

AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas

Stanford University

NCT06340737

RECRUITING Phase 1 120 participants

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

CRISPR Therapeutics

NCT05643742

RECRUITING Phase 1 120 participants

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

Carna Biosciences

NCT05602363

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING 100 participants

Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study

Mayo Clinic

NCT06151730

RECRUITING Phase 1 80 participants

A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

Enterome

NCT04669171

RECRUITING Phase 2 65 participants

HM2023-43:Ph 2 Trial of Tafasitamab With Lenalidomide+Rituximab in Treatment-naive FL and MZL

Masonic Cancer Center, University of Minnesota

NCT06792825

RECRUITING Phase 1 60 participants

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Newave Pharmaceutical

NCT04775745

RECRUITING Phase 2 52 participants

Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone Lymphoma

Brown University

NCT04792502

RECRUITING Phase 2 50 participants

Open-label of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Marginal Zone Lymphoma

University of Miami

NCT05296070

RECRUITING Phase 2 49 participants

Acalabrutinib and Obinutuzumab for the Treatment of Previously Untreated Follicular Lymphoma or Other Indolent Non-Hodgkin Lymphomas

Emory University

NCT04883437

RECRUITING Phase 2 45 participants

Epco, Zanu, Ritux for R/R FL or MZL

Reid Merryman, MD

NCT06563596

RECRUITING Phase 2 43 participants

Rituximab and Zanubrutinib in Patients With Indolent B-cell Lymphomas

H. Lee Moffitt Cancer Center and Research Institute

NCT06350318

RECRUITING Phase 1 42 participants

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

Acepodia Biotech

NCT05653271

RECRUITING Early Phase 1 42 participants

64Cu-LLP2A for Imaging Hematologic Malignancies

Washington University School of Medicine

NCT06636175

RECRUITING NA 40 participants

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

UNC Lineberger Comprehensive Cancer Center

NCT06860880

RECRUITING Phase 2 33 participants

Rituximab Plus Venetoclax in Front Line Marginal Zone Lymphoma

Gottfried von Keudell, MD PhD

NCT06510309

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 2 27 participants

Pemigatinib in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas

University of Utah

NCT06300528

RECRUITING Phase 2 25 participants

Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL)

Izidore Lossos, MD

NCT06796998

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 2 23 participants

Pirtobrutinib in Combination With Rituximab in Adults With Untreated Marginal Zone Lymphoma (PIONEER-MZL)

University of Utah

NCT06390956

RECRUITING Phase 1 18 participants

SynKIR-310 for Relapsed/Refractory B-NHL

Verismo Therapeutics

NCT06544265

RECRUITING Phase 1 12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Medical College of Wisconsin

NCT05990465

ACTIVE NOT RECRUITING Phase 3 654 participants

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

Incyte Corporation

NCT04680052

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 2 47 participants

Glofit and Obin in Follicular Lymphoma and Marginal Zone Lymphoma

Reid Merryman, MD

NCT05783596

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

ACTIVE NOT RECRUITING Phase 1 30 participants

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Memorial Sloan Kettering Cancer Center

NCT04464200

ACTIVE NOT RECRUITING Phase 1 27 participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT03884998

ACTIVE NOT RECRUITING Phase 3 23 participants

A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma

Memorial Sloan Kettering Cancer Center

NCT04212013

ACTIVE NOT RECRUITING Phase 2 6 participants

A Phase II Study Using Rituximab Plus Venetoclax in the Front Line Treatment of Marginal Zone Lymphoma

Memorial Sloan Kettering Cancer Center

NCT04416451

COMPLETED 174 participants

Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

Children's Oncology Group

NCT01000753

COMPLETED Phase 2 125 participants

Efficacy and Safety Study of Idelalisib in Participants With Indolent B-Cell Non-Hodgkin Lymphomas

Gilead Sciences

NCT01282424

COMPLETED Phase 1 91 participants

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03833180

COMPLETED Phase 2 63 participants

Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed/Refractory Marginal Zone Lymphoma

Pharmacyclics

NCT01980628

COMPLETED Phase 1 60 participants

Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT00880815

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED Phase 2 42 participants

Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma

University of Washington

NCT05169658

COMPLETED Phase 1 39 participants

Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

TG Therapeutics

NCT01647971

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 2 21 participants

Study to Assess the Efficacy and Safety of Umbralisib in Participants With Non-Follicular Indolent Non-Hodgkin's Lymphoma

TG Therapeutics

NCT03364231

COMPLETED Phase 1 11 participants

Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

National Cancer Institute (NCI)

NCT04599634

Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 20
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Marginal Zone Lymphoma Trial Landscape

ClinicalTrials.gov lists 50 US studies indexed under Marginal Zone Lymphoma, and 28 of those are currently open to recruitment — roughly 56% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Marginal Zone Lymphoma shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 43 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Marginal Zone Lymphoma is led by Memorial Sloan Kettering Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 50 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Marginal Zone Lymphoma?

PlainTrial tracks 50 US clinical trials for Marginal Zone Lymphoma, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Marginal Zone Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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