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Avatrombopag vs. Placebo for CIT in GI Malignancies
NCT05772546 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to compare the efficacy of two study drugs, Avatrobopag versus placebo, to treat persistent Chemotherapy-Induced Thrombocytopenia (CIT) in patients with gastrointestinal (GI) malignancies receiving cytotoxic chemotherapy. The names of the study drugs involved in this study are: * Avatrombopag (a thrombopoietin receptor agonist) * Matching placebo
Conditions Studied
Interventions
- DRUG Matching Placebo
- DRUG Avatrombopag
Study Locations (4)
Florida
- University of Miami Sylvester Comprehensive Cancer Center — Miami
Massachusetts
- Massachusetts General Hospital Cancer Center — Boston
Oregon
- Oregon Health and Science University Hospital — Portland
Washington
- University of Washington Fred Hutchinson Cancer Center — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-11-01 |
| Est. Completion | 2026-07-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05772546
The ClinicalTrials.gov registry entry for NCT05772546 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hanny Al-Samkari, MD, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Gastrointestinal Cancer appearing as the primary indexed condition, and to 2 interventions — of which Matching Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05772546 reports 4 study locations spanning 4 distinct geographic areas — top geographies include Florida, Massachusetts, Oregon. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05772546 about?
NCT05772546 is a clinical study titled "Avatrombopag vs. Placebo for CIT in GI Malignancies". The purpose of this study is to compare the efficacy of two study drugs, Avatrobopag versus placebo, to treat persistent Chemotherapy-Induced Thrombocytopenia (CIT) in patients with gastrointestinal (GI) malignancies receiving cytotoxic chemotherapy. The names of the study drugs involved in this st...
What is the current status of trial NCT05772546?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2023-11-01. Estimated completion is 2026-07-31.
What conditions does trial NCT05772546 study?
This clinical trial studies the following conditions: Gastrointestinal Cancer, Gastrointestinal Neoplasms, Chemotherapy-Induced Thrombocytopenia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05772546?
The interventions under investigation include: Matching Placebo (DRUG), Avatrombopag (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05772546?
This trial is sponsored by Hanny Al-Samkari, MD, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05772546 being conducted?
This trial has 4 study locations across Florida, Massachusetts, Oregon, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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