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Frontotemporal Dementia: early-phase trial registry
11 of 23 indexed Frontotemporal Dementia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #724 of 28,707 conditions by registered trial count.
23 US clinical trials · 11 currently recruiting · #724 of 28,707 conditions by registered trial count
Frontotemporal Dementia: 23 US clinical trials tracked, 11 recruiting.
Frontotemporal Dementia is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is University of Miami, running 2 of these trials.
Enrollment posture brief
Registry condition frontotemporal-dementia
OPEN 11 | RECR 48% | LATE 0 | EARLY 8 | RANK #724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Dementia With Lewy Bodies (48% recruiting · 23 trials)
Frontotemporal Dementia lists 11 open slots (48% of 23 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Frontotemporal Dementia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Frontotemporal Dementia is recruiting above its size-band peers.
11 of 23 indexed trials (47.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Frontotemporal Dementia trials is spread across many organizations.
University of Miami accounts for 2 of 23 trials (8.7%). 22 distinct sponsors appear on at least one study for this condition label.
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Typical Frontotemporal Dementia enrolment sits around 102 participants.
Median target enrolment is 102 among the 23 trials that report a genuine target (sentinel values excluded). 11 of those (47.8%) plan for fewer than 100 participants.
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Frontotemporal Dementia splits between interventional and observational designs.
13 interventional and 10 observational studies make up this index (56.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
23 total, page 1 of 1
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
NYSCF Scientific Discovery Biobank
New York Stem Cell Foundation Research Institute
NCT06203106
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
University of Pennsylvania
NCT06377033
STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners
Oregon Health and Science University
NCT06613204
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03225144
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
David Wilson
NCT05374278
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
University of California, Irvine
NCT01353430
Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
Johns Hopkins University
NCT06604520
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
Passage Bio
NCT04747431
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio
NCT06064890
TRIAL READY (Clinical Trial Readiness)
University of Miami
NCT03912987
A Study of Caregiver Connections Via Technology in Dementia
Mayo Clinic
NCT05779839
Neurofilament Surveillance Project (NSP)
The Bluefield Project to Cure Frontotemporal Dementia
NCT04516499
Phenotype, Genotype and Biomarkers 2
University of Miami
NCT04875416
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
Denali Therapeutics
NCT05262023
Music, Social Attention, and Dementia
University of California, San Francisco
NCT06768996
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
Massachusetts General Hospital
NCT05956834
Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
University of Florida
NCT04220021
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
Prevail Therapeutics
NCT04408625
A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research
University of Wisconsin, Madison
NCT05444244
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation
Alector
NCT03636204
Connectomics in Psychiatric Classification
Washington University School of Medicine
NCT03967535
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Frontotemporal Dementia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Frontotemporal Dementia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Frontotemporal Dementia page
23 registered trials, 11 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 11 Frontotemporal Dementia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Miami sponsors the most Frontotemporal Dementia trials on record, review their full trial history before evaluating a specific study. See University of Miami's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Frontotemporal Dementia condition card totals 23 registered trials; most-linked intervention Mental Health Assessment and Computerized Cognitive Test; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.