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Frontotemporal Dementia clinical trials
11 of 23 indexed Frontotemporal Dementia trials are currently recruiting.
23 US clinical trials · 11 currently recruiting
Frontotemporal Dementia is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is University of Miami, running 2 of these trials.
The research picture
Frontotemporal Dementia has 23 registered US clinical trials, 11 of them open to new participants right now, about 48% of the total.
- 11
- recruiting participants now
- 48%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 2
- top sponsor: University of Miami
Active & Recent Trials
23 total, page 1 of 1
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
NYSCF Scientific Discovery Biobank
New York Stem Cell Foundation Research Institute
NCT06203106
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
University of Pennsylvania
NCT06377033
STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners
Oregon Health and Science University
NCT06613204
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03225144
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
David Wilson
NCT05374278
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
University of California, Irvine
NCT01353430
Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
Johns Hopkins University
NCT06604520
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
Passage Bio
NCT04747431
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio
NCT06064890
TRIAL READY (Clinical Trial Readiness)
University of Miami
NCT03912987
A Study of Caregiver Connections Via Technology in Dementia
Mayo Clinic
NCT05779839
Neurofilament Surveillance Project (NSP)
The Bluefield Project to Cure Frontotemporal Dementia
NCT04516499
Phenotype, Genotype and Biomarkers 2
University of Miami
NCT04875416
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
Denali Therapeutics
NCT05262023
Music, Social Attention, and Dementia
University of California, San Francisco
NCT06768996
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
Massachusetts General Hospital
NCT05956834
Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
University of Florida
NCT04220021
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
Prevail Therapeutics
NCT04408625
A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research
University of Wisconsin, Madison
NCT05444244
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation
Alector
NCT03636204
Connectomics in Psychiatric Classification
Washington University School of Medicine
NCT03967535
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Frontotemporal Dementia Trial Landscape
23 indexed Frontotemporal Dementia studies · 11 recruiting (48%).
Phase mix: 0 late (III/IV) vs 8 early (I/II).
Top sponsor: University of Miami (2 trials), 9 others listed. 23 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Frontotemporal Dementia?
PlainTrial tracks 23 US clinical trials for Frontotemporal Dementia, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Frontotemporal Dementia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.